空间的力量 新奥胡斯大学医院

正新奥胡斯大学医院是丹麦第一个超大型的医院案例,也是一个具有"康复医疗"概念的、超现代的国际先锋作品。医院的建筑设计通过系统运用"信息和循证"的工作方法,践行了"康复建筑"的综合理念。其"信息和循证"的方法是利用对现存建筑的研究和评估,以提供最有效的信息来创建最佳的康复建筑。从单人病房的设计、日光和光线的利用,以及景观和花园空间的设计,旨在尽量满足病人的需求,提升     

阿里红多糖对Aβ1‒42诱导的AD大鼠模型海马区及脑皮层ROS/8-OHdG/3-NT/4-HNE含量的影响

[摘要] 目的：观察阿里红多糖（Fomes officinalis Ames polysaccharides，FOPS）对阿尔茨海默病（AD）模型大鼠海马区神经元的形态改变及脑皮层和海马区氧化应激水平的影响。方法：72只健康雄性SD大鼠称体质量并按随机原则分为空白组、模型组、盐酸多奈哌齐组（0.5 mg/kg）、阿里红多糖高、中、低剂量组(100 mg/kg、50 mg/kg、25 mg/kg)，每组12只。采用大鼠双侧海马CA1区注射（5μl/侧）Aβ1-42建立AD大鼠模型，给药30d后，苏木精-伊红（HE）染色观察海马神经元的形态改变，DCFH-DA荧光探针分析处理对各组大鼠海马区和脑皮质层中活性氧簇（ROS）的影响，酶联免疫吸附（ELISA）法检测8羟基脱氧鸟苷（8-OHdG）、3-硝基酪氨酸（3-NT）、4羟基壬烯醛（4-HNE）的含量。结果：干预30d后，与模型组比较，盐酸多奈哌齐及阿里红多糖组大鼠锥体细胞数目明显增多、形态较完整、海马神经元大多数较正常、排列较规整紧密、着色均匀、核仁清晰，大鼠海马区及脑皮层ROS含量明显降低(P<0.01)，8-OHdG、3-NT、4-HNE含量明显降低(P<0.01)。结论：阿里红多糖通过影响Aβ1-42诱导的AD大鼠脑内ROS、8-OHdG、3-NT、4-HNE含量，改善脑内氧化应激状态，起到改善认知障碍和保护神经的作用。     

阿纳其根醇提物对D-半乳糖致衰老小鼠抗衰老作用的血清核磁共振代谢组学研究

目的 利用核磁共振代谢组学方法研究阿纳其根提取物对D-半乳糖致衰老小鼠抗衰老作用机制。方法 选取3月龄的昆明小鼠60只并将其随机分为正常组、模型组、阳性对照组和阿纳其根95%醇提物低、中、高剂量给药组,正常组以外的小鼠每天1次皮下注射D-半乳糖100mg/kg的同时对阿纳其根低、中、高剂量给药组分别灌胃相应浓度的阿纳其根95%醇提物(1.5g/kg,3.0g/kg,6g/kg),对阳性对照组灌胃盐酸多奈哌齐(0.92mg/kg),模型组灌胃等体积的生理盐水,连续给药45d, 第45d末次给药1h后利用Morris水迷宫实验观察小鼠学习和记忆能力并收集各组小鼠血清,用核磁共振波谱(_¹H-NMR)技术测定核磁共振氢谱,采用PLS-DA法和OPLS-DA法分析研究每组小鼠血清中代谢产物差异。结果 行为学检测结果显示与模型组小鼠比较,阳性对照组和阿纳其根醇提物不同剂量组的逃避潜伏期和游泳距离逐渐缩短,差异有统计学意义(P＜0.01),各组小鼠的空间探索实验,与模型组相比,阿纳其根95%醇提物各剂量组小鼠经过有效区次数增加(P＜0.05);各组血清多种代谢物有显著性差异,阿纳其根提取物低、中、高剂量给药组小鼠血清中β-葡萄糖、α-葡萄糖、脂类(VLDL)、脂类(LDL)、缬氨酸、丙酮酸、亮氨酸、酪氨酸、乳酸、组氨酸、乳酸、胆碱、甲酸含量升高;糖蛋白、谷氨酰胺、肌醇、乙酸、蛋氨酸、乙酰半胱氨酸、谷氨酰胺、肌醇、甘氨酸、肌酸、鲨肌醇、乙酸、蛋氨酸、异亮氨酸含量降低。结论 D-半乳糖诱导的衰老模型小鼠的糖代谢代谢、氨基酸代谢发生紊乱,而阿纳其根醇提物对其紊乱有一定的改善作用从而发挥抗衰老作用。     

泥炭泥浆在治疗中的放射性

正为确定泥炭泥浆中天然和人工同位素的含量,并估算标准泥炭泥浆处理过程中患者皮肤吸收的辐射剂量,分析了从波兰8个矿泉采集的37个样本,用γ能谱法测量同位素浓度活性。标准泥炭泥浆浴治疗中的皮肤剂量约为300 nSv,泥炭泥浆这种治疗的有效剂量被认为是22 nSv。治疗过程中     

Toward Energy-Efficient and Trustworthy eHealth Monitoring System

The rapid technological convergence between Internet of Things(IoT),Wireless Body Area Networks(WBANs)and cloud computing has made e-healthcare emerge as a promising application domain,which has significant potential to improve the quality of medical care.In particular,patient-centric health monitoring plays a vital role in e-healthcare service,involving a set of important operations ranging from medical data collection and aggregation,data transmission and segregation,to data analytics.This survey paper firstly presents an architectural framework to describe the entire monitoring life cycle and highlight the essential service components.More detailed discussions are then devoted to {\em data collection} at patient side,which we argue that it serves as fundamental basis in achieving robust,efficient,and secure health monitoring.Subsequently,a profound discussion of the security threats targeting eHealth monitoring systems is presented,and the major limitations of the existing solutions are analyzed and extensively discussed.Finally,a set of design challenges is identified in order to achieve high quality and secure patient-centric monitoring schemes,along with some potential solutions.     

Strain rate dependency and fragmentation pattern of expanding warheads

For the characterization of the behaviors of a metal material in events like expanding warheads, it is necessary to know its strength and ductility at high strain rates, around 104e105/s. The flyer plate impact testing produces the uniform stress and strain rates but the testing is expensive. The Taylor test is relatively inexpensive but produces non-uniform stress and strain fields, and the results are not so easily inferred for material modeling. In the split-Hopkinson bar(SHB), which may be used in compression, tension and torsion testing, the strain rates never exceeds 103/s. In the present work, we use the expanding ring test where the strain rate is 104e105/s. A streak camera is used to examine the expanding ring velocity, and a water tank is used to collect the fragments. The experimental results are compared with the numerical simulations using the hydrocodes AUTODYN, IMPETUS Afea and a regularized smooth particle(RSPH) software. The number of fragments increases with the increase in the expansion velocity of the rings. The number of fragments is similar to the experimental results. The RSPH software shows much the same results as the AUTODYN where the Lagrangian solver is used for the ring. The IMPETUS Afea solver shows a somewhat different fragmentation characteristic due to the node splitting algorithm that induces pronounced tensile splitting.     

“至上”与“虚无”

<正>俄国画家马列维奇是"至上主义"抽象绘画流派的创始者,其绘画作品简约而纯粹,以最简单的形式——方块展现出艺术家丰富的感情世界,探索了形体、色彩与空间的关系。而同样善于运用几何形态的西班牙雕塑家奥泰萨的风格则显得冷静而克制,其雕塑作品通常看起来虚幻而抽象,没有强烈的情感表现,以高度理性化的手法展现出一种"虚无"的艺术境界。二人所专注的领域虽有不同,但他们的作品都在关注形式与其所在空间之间的复杂关系。     

香港大馆

<正>位于香港商业中心的"大馆",其前身是中央警署、中央裁判法院及域多利监狱,一座由各种历史建筑组成并被围墙围起的古建筑群,而如今是香港现存最重要的历史遗址之一。在2006年停止使用并清空后,这里只留下一块空地以及一系列独特的建筑,其中院落由阅兵场及监狱两大部分组成。设计团队的目标是保持二者的开放性及独立性的同时赋予它们新的活     

Neutronic study on the effect of first wall material thickness on tritium production and material damage in a fusion reactor

In this study, the effects of changing first wall materials and their thicknesses on a reactor were investigated to determine the displacement per atom（DPA） and gas production（helium and hydrogen） in the first wall, as well as the tritium breeding ratio（TBR） in the coolant and tritium breeding zones. Therefore, the modeling of the magnetic fusion reactor was determined based on the blanket parameters of the International Thermonuclear Experimental Reactor（ITER）. Stainless steel（SS 316 LNIG）, Oxi...