Lactobacillus reuteri-fortified camel milk infant formula: Effects of encapsulation,in vitro digestion,and storage conditions on probiotic cell viability and physicochemical characteristics of infant formula

Lactobacillus reuteri fortified camel milk infant formula (CMIF) was produced. The effect of encapsulation in different matrices (sodium alginate and galacto-oligosaccharides) via spray drying, simulated infant gastrointestinal digestion (SIGID), and storage conditions (temperature and humidity) on the viability of L. reuteri in CMIF and the physicochemical properties of CMIF were evaluated. Compared with free cells, probiotic cell viability was significantly enhanced against SIGID conditions upon encapsulation. However, L. reuteri viability in CMIF decreased after 60 d of storage, predominantly at higher storage humidity and temperature levels. At the end of the storage period, significant changes in the color values were observed in all CMIF, with a reduction in their greenness, an increase in yellowness, and a wide variation in their whiteness. Moreover, pH values and caking behavior of all CMIF stored at higher temperature (40°C) and humidity [water activity (a_w) = 0.52] levels were found to be significantly higher than the samples stored under other conditions. Over 30 d of storage at lower humidity conditions (a_w = 0.11 and 0.33) and room temperature (25°C), no significant increase in CMIF lipid oxidation rates was noted. Fourier-transform infrared spectroscopy analysis showed that, compared with the other storage conditions, CMIF experienced fewer changes in functional groups when stored at a_w = 0.11. Microscopic images showed typical morphological characteristics of milk powder, with round to spherical-shaped particles. Overall, camel milk fortified with encapsulated L. reuteri can be suggested as a promising alternative in infant formula industries, potentially able to maintain its physicochemical characteristics as well as viability of probiotic cells when stored at low humidity levels (a_w = 0.11) and temperature (25°C), over 60 d of storage.     

皮肤T细胞淋巴瘤局部用药和物理治疗的研究进展

皮肤T细胞淋巴瘤(cutaneous T cell lymphoma,CTCL)大多属于惰性淋巴瘤,病情进展缓慢,患者确诊时多处于疾病早期。局部用药和物理治疗在CTCL治疗中占重要地位,包括局部外用皮质类固醇激素、免疫抑制剂、维A酸,放疗及光疗等。近年来,有研究对CTCL传统局部用药和物理治疗方法的有效性和安全性进行了重新评估。同时,新型CTCL局部用药和物理治疗策略也不断涌现,如局部外用他扎罗汀、瑞喹莫特,紫外线A联合新型光敏剂的光化学疗法和光动力治疗等。本文对CTCL局部用药和物理治疗的研究进展作一综述。     

Impact of Divalent Ions on Heavy Oil Recovery by in situ Emulsification

Many reservoir formation brines are characterized by high salinity and contain high concentrations of divalent ions such as calcium, magnesium, and potassium. These challenging conditions can render the surfactants ineffective during chemical flooding for enhanced heavy oil recovery. Various brine types can have an impact on the stability of emulsions generated with chemicals as chemicals have various resistant levels toward hard divalent ions and salinities. To investigate the impact of brine hardness on heavy oil-in-water emulsion stability, glass tube experiments, microscopic visualization and sandpack flooding experiments, and Hele-Shaw visualization experiments were conducted in this study under low-salinity/hard-brine, high-salinity/hard-brine conditions using commercial chemicals, which are designed for specific reservoir brine conditions. Recovery results demonstrated that complex colloidal solution introduced in the previous study with silica and Dodecyltrimethylammonium bromide (DTAB) along with screened chemicals from glass tube tests in this study can enhance heavy oil recovery significantly with an addition of low concentration of xanthan gum (Lee and Babadagli 2018). The results confirmed the robustness of the complex colloidal solution formula to enhance oil recovery with low concentration of polymer under any reservoir brine conditions. The study also demonstrates the potential of polymer as an emulsion stabilization additive for enhanced heavy oil recovery by in situ emulsion generation. Polymer effects seemed to be particularly dominant under the low-salinity conditions than high-salinity conditions.     

新冠肺炎及呼吸系统病患所需全营养配方食品的开发

新冠肺炎的爆发和全球范围大流行震惊了世界,激发了消费者对食物结构和消费方式的新思考;卫生营养健康的科学理念和美好生活的诉求引起了社会广泛关注,这势必将对食品产业产生深远的影响,特别是刚刚兴起的特医产业。面对尚无特效药的新冠肺炎疫情集中聚集爆发,营养支持治疗是一线抗疫的重要干预手段,而适合于新冠临床患者的特殊医学用途配方食品尚属于空白。基于呼吸系统疾病人群病症特点和营养需求,根据合理配比宏量营养素供能比例,强化微量元素形成适用于呼吸系统疾病诊疗需求的特殊医学用途配方食品开发理念,通过原料配方筛选以及工艺研究和优化,最终形成针对呼吸系统疾病的特定全营养粉剂、乳剂和功能性脂肪乳,为疫情后的营养治疗与生命生存质量提供有力技术支持。     

高温、高湿和光照对特殊医用配方食品流变特性的影响

为确定特殊医用配方食品在高温、高湿、光照条件下的流变性变化,以豌豆肽为原料进行影响因素(高温、高湿、光照)试验、加速试验、长期试验,揭示环境因素对特殊医用配方食品黏性、弹性与流变性质的影响。特殊医用配方食品在高温下5 d之后食用安全性降低;在高湿条件下放置10 d左右的医用食品,其食用安全性相对于放置5 d左右的医用食品安全性要高;在光照条件下5 d之后食用安全性降低。由此可见,温度、湿度、光照对特殊医用配方的食用有很大影响。在加速试验及长期试验中,医用食品最佳保质期时间应控制在2~5个月。文章为具有广阔发展前景的特殊医用食品的开发、食用条件及储存条件提供理论数据和指导依据。     

血糯米牛轧糖配方优化的研究

添加血糯米粉制作血糯米牛轧糖。探讨麦芽糖与白砂糖的质量比、血糯米添加量、奶粉添加量和黄油添加量4个因素对血糯米牛轧糖感官评价和质构的影响,确定血糯米牛轧糖的最佳配方。结果表明,以麦芽糖浆用量为100%,当麦芽糖与白砂糖的质量比3∶1、血糯米添加量30%,奶粉添加量为80%,黄油添加量为25%时,生产的牛轧具有血糯米特有的香气,糖体的硬度和黏度适中,无甜腻感,口感最佳。     

面向流屑角突变建模的切削状态参数经验公式的获得及应用

从提高流屑角突变模型的预测精度出发,建立了切削状态参数与3个切削控制参数之间关系的新经验公式。提出了一种通过迭代法准确设定有限元仿真软件刀-屑摩擦因数的方法,并通过直角切削Al6061-T6工件的有限元仿真试验,获得了一组不同切削控制参数组合条件下的切削状态参数数据。根据该数据拟合出剪切角φ、刀-屑摩擦角β、剪切应力τs关于刀具前角γ0、进给量f和切削速度v的经验公式,并通过一组直角切削试验,验证了所得经验公式的有效性。将新建经验公式应用于流屑角突变建模过程后,所得模型关于突变临界切削宽度的平均预测误差减小了27.2%。     

培养原料种类的减少对人工窖泥发酵剂菌群结构的影响

为实现人工窖泥发酵剂（APMSC）的品质控制，从前期开发的发酵剂配方中分别取出老熟窖泥、曲药、酒糟和黄水初步形成4个简化配方，采用扩增子测序和色谱技术比较了各配方发酵剂的微生物群落结构及香味物质含量差异。结果显示，各配方发酵剂样品中共检测到70个微生物操作分类单元（OTU），其中71.43%为各组样品共有，未检测到独有OTU。各配方样品的优势微生物均存在于其余分组中，仅物种相对丰度有所差异。根据酿酒有益微生物的丰度高低，选择了一种简化配方（无老熟窖泥作原料）发酵剂养护窖池，使酿造白酒的主体香味物质含量得到显著提高。结果表明，即使缺失了某一种培养原料，人工窖泥发酵剂的功能微生物物种也可能由其他原料补充，而原料种类的减少是实现发酵剂品质控制的主要途径。     

山药复合营养面条加工工艺研究

以新鲜山药泥、小麦粉为主要原料,牛肉、胡萝卜、脱脂纯牛奶和食盐为辅料,制备一款营养丰富、无添加剂的新型山药复合营养面条。通过单因素试验、正交试验和感官评价,筛选山药复合营养面条配方;通过物性指标、微观结构确定山药复合营养面条的最佳配方为:山药泥35%、牛肉∶胡萝卜质量比为1∶1、脱脂纯牛奶3%和食盐2.5%。