Frequency response data-based peak filter design applied to MIMO large-scale high-precision scan stage

A large-scale high-precision scan stage is important equipment in the industrial productions of micro-fabrication such as flat panel display (FPD) lithography systems. Designing controllers for multi-input multi-output (MIMO) systems is time-consuming and needs experience because of the interaction between each axis and many controller tuning parameters. The aim of this study is to develop a peak filter design method based on frequency response data to reduce repetitive disturbance. This data-based approach does not use the model and only uses the frequency response data of the controlled system and the disturbance spectrum calculated from the scanning error data (Contribution 1). The peak filter is designed by convex optimization and satisfies robust stability conditions for six-degree-of-freedom systems (Contribution 2). The control performance of the designed peak filter is experimentally demonstrated with an industrial MIMO large-scale high-precision scan stage in reducing the scanning error of the main stroke of the translation along the $x$-axis (Contribution 3).     

Exploring Molecular Contacts of MUC1 at CIN85 Binding Interface to Address Future Drug Design Efforts

The modulation of protein-protein interactions (PPIs) by small molecules represents a valuable strategy for pharmacological intervention in several human diseases. In this context, computer-aided drug discovery techniques offer useful resources to predict the network of interactions governing the recognition process between protein partners, thus furnishing relevant information for the design of novel PPI modulators. In this work, we focused our attention on the MUC1-CIN85 complex as a crucial PPI controlling cancer progression and metastasis. MUC1 is a transmembrane glycoprotein whose extracellular domain contains a variable number of tandem repeats (VNTRs) regions that are highly glycosylated in normal cells and under-glycosylated in cancer. The hypo-glycosylation fosters the exposure of the backbone to new interactions with other proteins, such as CIN85, that alter the intracellular signalling in tumour cells. Herein, different computational approaches were combined to investigate the molecular recognition pattern of MUC1-CIN85 PPI thus unveiling new structural information useful for the design of MUC1-CIN85 PPI inhibitors as potential anti-metastatic agents.     

Sizing of multi-stage Op Amps by combining design equations with the gm/ID method

Analog integrated circuit design has as integral parts both analytical reasoning and numerical validation in the process from topology construction to sizing. Given a circuit topology, different circuit sizing results can be obtained from different processes of sizing inference. Sizing methods by simulation-based numerical searching have been a continuously studied subject. However, almost all approaches in this category require an overwhelming number of circuit simulations to arrive at an optimized sizing result. On the other hand, many published manual sizing methods by using the conventional device equations also require repeated SPICE simulations to correct the equation-based sizing results. This paper proposes a systematic gm/ID-based initial sizing method specifically customized for designing multiple-stage operational amplifiers (Op Amps). A main feature of the proposal is to use circuit-level design equations as constraints on the gm/ID table lookup method to substantially reduce the uncertainty in the sizing calculations. As a result, a significant amount of SPICE based correction work can be reduced to complete an initial sizing. The proposed sizing procedure includes a few regular sizing rules customized to the configuration of multi-stage Op Amps. We validate the proposed sizing method by application to several multi-stage Op Amp examples with a capacitive load or Miller compensation. Simulations have justified that the produced initial sizing results can achieve most of the prespecified design targets.     

Domain reversal and current transport property in BiFeO3 films

The electrical properties and domain reversal in BiFeO₃ ferroelectric films were studied using sandwiched heterostructures and piezoresponse force microscopy. A robust polarization state was observed, combined with a switchable domain pattern and a remanent polarization of approximately 100 μC cm^?2. In addition, domain reversal was explored using scanning probe microscopy. The results show that dipoles could be reversed along the direction of the electric field under a negative tip bias, leading to carrier gathering near the domain walls. The enhanced conductivity near the domain walls was owing to the discontinuous polarization boundary conditions. In addition, typical diode-like current transport properties are sensitive to various temperature conditions, which is attributed to the Schottky barriers at the contact interface. These findings extend the current understanding of domain texture reversal in ferroelectric films and shed light on their potential applications for future ferroelectric random-access memory operations over a wide temperature range.     

非分裂完全匹配层边界存储时间域全波形反演

正演波场的储存或重建是制约时间域全波形反演的关键问题，以计算代替存储的常规分裂完全匹配层（PML）边界存储策略可有效减少存储量。但常规分裂PML边界条件所需变量个数多、计算存储量大以及编程复杂。为此，采用非分裂复频移完全匹配层（CFS-NPML）有效边界存储策略重建正演波场实现时间域全波形反演。研究表明：CFS-NPML所需变量个数少，在边界吸收层网格点较少时吸收效果优于常规PML边界条件，波场重建过程中所需存储量少于常规PML边界条件。数值试验表明，该存储策略得到的重建波场与正向传播波场几乎无差别，其全波形反演结果与常规保存波场反演法一致；正演过程中引入并行计算技术未显著增加波场重建导致的额外正演时间。     

重庆下古生界页岩顺层滑脱变形域的形成及其地质意义

在野外露头和岩心观察基础上，通过力学分析，对重庆下古生界页岩中顺层滑脱变形域的类型、特征及其形成进行了研究，并结合页岩气勘探实践，对其地质意义进行了探讨。顺层滑脱变形域包括挤压型和重力型两类。挤压型顺层滑脱变形域形成时水平挤压构造应力占主导地位，岩层发生“逆断层”运动；重力型顺层滑脱变形域形成时上覆地层压力占主导地位，岩层发生"正断层"运动。挤压型顺层滑脱变形域地层变形相对较强，影响范围相对较大。埋藏深度和岩层倾角是控制同一地区同一页岩层中顺层滑脱变形域形成的关键地质要素。页岩埋深越大，形成挤压型顺层滑脱变形域时的临界岩层倾角越大，而形成重力型顺层滑脱变形域的临界岩层倾角则越小。重力型顺层滑脱变形域破坏页岩气保存条件。背斜构造部位挤压型顺层滑脱变形域所形成的顺层破碎带和网状裂缝系统是页岩气重要的运移通道和储集空间，向斜构造部位挤压型顺层滑脱变形域所形成的顺层破碎带和网状裂缝系统成为页岩气向临近背斜构造部位运移或向地表散失的重要通道。     

相似系数阈值滤波的数据驱动控制束偏移

高斯束偏移不仅具有接近波动方程偏移的精度，而且具有Kirchhoff偏移灵活、高效的特点。然而当实际地震采集数据中含有较强噪声时，易产生偏移假象而影响成像质量。为此，在传统高斯束偏移的基础上，根据有效信号和干扰信号在τ-p域中的相干性差异，发展了一种基于相似系数阈值滤波的数据驱动控制束偏移方法。采用数据驱动策略，在高斯束偏移成像过程中，先计算τ-p道集的相似系数，再通过设定相似系数阈值控制干扰信号，从而降低偏移剖面中的随机噪声；控制束偏移可以直接提取角度域共成像点道集，无需复杂的角度映射变换且具有更高信噪比。模型测试及实际资料处理结果表明：对于低信噪比数据，控制束偏移剖面的信噪比明显高于常规高斯束偏移，但会损失相对振幅的可靠性；尽管控制束偏移在τ-p道集的滤波过程增加了一定的计算量，但总体与常规高斯束偏移方法的计算效率相当；相似系数阈值参数选取十分关键，阈值较小时偏移噪声较强，但过大阈值也可能压制部分有效信息或产生偏移假象，选取合适的阈值参数才能得到较理想的偏移剖面。     

Evaluation of dynamic modulus measurement for C/C-SiC composites at different temperatures

The determination of elastic properties at application temperature is fundamental for the design of fibre reinforced ceramic composite components. An attractive method to characterize the flexural modulus at room and high temperature under specific atmosphere is the nondestructive Resonant Frequency Damping Analysis (RFDA). The objective of this paper was to evaluate and validate the modulus measurement via RFDA for orthotropic C/C-SiC composites at the application temperature. At room temperature flexural moduli of C/C-SiC with 0/90° reinforcement were measured under quasi-static 4-point bending loads and compared with dynamic moduli measured via RFDA longitudinally to fibre direction. The dynamic modulus of C/C-SiC was then measured via RFDA up to 1250°C under flowing inert gas and showed an increase with temperature which fitted with literature values. The measured fundamental frequencies were finally compared to those resulting from numerical modal analyses. Dynamic and quasi-static flexural moduli are comparable and the numerical analyses proved that bending modes are correctly modeled by means of dynamic modulus measured via RFDA. The nondestructive RFDA as well as the numerical modeling approach are suitable for evaluation of C/C-SiC and may be transferred to other fibre reinforced ceramic composite materials.     

基于稀疏反演的高效混采数据分离方法

混叠采集技术能极大地提高地震采集效率，但是由于连续激发，混采数据中存在严重的邻炮干扰噪声，而且混采数据规模巨大，这要求后续的信噪分离算法精确、稳定、快速，为此提出一种基于稀疏反演的高效混采数据分离方法。在三维共检波点道集上，首先通过三维快速傅里叶变换，将时空域数据变换到频率-波数-波数域（FKK）；然后采用硬阈值函数提取相干信号，利用相干信号预测混叠噪声；最后以数据残差为驱动，不断收缩阈值，迭代更新模型，实现高效混采数据分离。模拟数据和实际数据应用结果表明，本文方法能够精确、稳定、快速地分离高混叠度的地震数据。