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Xiao-Lei Qiu Zi-Rui Fan Yang-Yang Liu Ding-Fu Wang Shi-Xin Wang Chun-Xia Li 《International journal of molecular sciences》2021,22(8)
A self-nanoemulsifying drug delivery system (SNEDDS) was developed to enhance the absorption of heparin after oral administration, in which heparin was compounded with phospholipids to achieve better fat solubility in the form of heparin-phospholipid (HEP-Pc) complex. HEP-Pc complex was prepared using the solvent evaporation method, which increased the solubility of heparin in n-octanol. The successful preparation of HEP-Pc complex was confirmed by differential scanning calorimetry (DSC), Fourier-transform infrared (FT-IR) spectroscopy, NMR, and SEM. A heparin lipid microemulsion (HEP-LM) was prepared by high-pressure homogenization and characterized. HEP-LM can enhance the absorption of heparin after oral administration, significantly prolong activated partial thromboplastin time (APTT) and thrombin time (TT) in mice, and reduce fibrinogen (FIB) content. All these outcomes indicate that HEP-LM has great potential as an oral heparin formulation. 相似文献
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邓乐善 《中国水能及电气化》2021,(1):56-58
针对民乐县农村人饮机井水位自动供水系统控制中存在的可靠性低、成本高等问题,文章结合深井泵提取地下水进行供水的实际情况,提出了软启动控制柜+浮球开关+微电脑时间控制器改进的思路和方法,运用效果良好。 相似文献
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Yujie Chen Yiping Song Zhen Zhang Yali Chen Qiliang Deng Shuo Wang 《Advanced functional materials》2021,31(41):2104885
Various products, including foods and pharmaceuticals, are sensitive to temperature fluctuations. Thus, temperature monitoring during production, transportation, and storage is critical. Facile indicators are required to monitor temperature conditions via color changes in real time. This study aimed to prepare and apply thiol-functionalized covalent organic frameworks (COFs) as a novel indicator for monitoring thermal history and temperature abuse. The COFs underwent obvious color changes from bright yellow to purple after exposure to different temperatures for varying durations. The reaction kinetics are analyzed under isothermal conditions, which reveal that the order of reaction rates is k−20°C < k4°C < k20°C < k35°C < k55°C. The activation energy (Ea) of the COFs is calculated using the Arrhenius equation as 50.71 kJ moL−1. The COFs are capable of sensitive color changes and offer a broad temperature tracking range, thereby demonstrating their application potential for the monitoring of temperature and time exposure history during production, transportation, and storage. This excellent performance thermal history indicator also shows promise for expanding the application field of COFs. 相似文献
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谭金军 《自动化技术与应用》2021,40(1):181-183
为进一步提升企业思想政治教育工作的信息化水平,本文详细介绍了企业思想政治教育系统的数据库设计方案,以便更加充分地发挥各种多媒体教学设备在企业思想政治教育工作方面的优势。 相似文献
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In this paper, a novel method is proposed for increasing the performance through coupling of top-down models adjusting the object detector based on a new loss function. Generally, object detectors and keypoint estimators are sequentially used in real-time multi-person pose estimations; however, these two models are separately trained. Therefore, the results of the object detector are not optimized for the keypoint estimator. To solve this problem, we analyze the relationship between the two models and propose a feedback-based loss optimization in the object detector, based on the estimation results of the keypoint estimator. In addition, the resulting bounding box of the object detector is readjusted to improve the accuracy of the keypoint estimation model. The experimental results demonstrate that the proposed approach can perform real-time operations with a high frame rate similar to that of the baseline model. Moreover, it achieved an accuracy of 74.2 average precision (AP), which is higher than the state-of-the-arts model including the human detector used in the experiment. 相似文献
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