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1.
Leucokinins (LKs) constitute a family of neuropeptides identified in numerous insects and many other invertebrates. LKs act on G-protein-coupled receptors that display only distant relations to other known receptors. In adult Drosophila, 26 neurons/neurosecretory cells of three main types express LK. The four brain interneurons are of two types, and these are implicated in several important functions in the fly’s behavior and physiology, including feeding, sleep–metabolism interactions, state-dependent memory formation, as well as modulation of gustatory sensitivity and nociception. The 22 neurosecretory cells (abdominal LK neurons, ABLKs) of the abdominal neuromeres co-express LK and a diuretic hormone (DH44), and together, these regulate water and ion homeostasis and associated stress as well as food intake. In Drosophila larvae, LK neurons modulate locomotion, escape responses and aspects of ecdysis behavior. A set of lateral neurosecretory cells, ALKs (anterior LK neurons), in the brain express LK in larvae, but inconsistently so in adults. These ALKs co-express three other neuropeptides and regulate water and ion homeostasis, feeding, and drinking, but the specific role of LK is not yet known. This review summarizes Drosophila data on embryonic lineages of LK neurons, functional roles of individual LK neuron types, interactions with other peptidergic systems, and orchestrating functions of LK. 相似文献
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Vanessa Modelski Schatkoski Thaís Larissa do Amaral Montanheiro Beatriz Rossi Canuto de Menezes Raissa Monteiro Pereira Karla Faquine Rodrigues Renata Guimarães Ribas Diego Morais da Silva Gilmar Patrocínio Thim 《Ceramics International》2021,47(3):2999-3012
Studies related to biomaterials that stimulate the repair of living tissue have increased considerably, improving the quality of many people's lives that require surgery due to traumatic accidents, bone diseases, bone defects, and reconstructions. Among these biomaterials, bioceramics and bioactive glasses (BGs) have proved to be suitable for coating materials, cement, scaffolds, and nanoparticles, once they present good biocompatibility and degradability, able to generate osteoconduction on the surrounding tissue. However, the role of biomaterials in hard tissue engineering is not restricted to a structural replacement or for guiding tissue regeneration. Nowadays, it is expected that biomaterials develop a multifunctional role when implanted, orchestrating the process of tissue regeneration and providing to the body the capacity to heal itself. In this way, the incorporation of specific metal ions in bioceramics and BGs structure, including magnesium, silver, strontium, lithium, copper, iron, zinc, cobalt, and manganese are currently receiving enhanced interest as biomaterials for biomedical applications. When an ion is incorporated into the bioceramic structure, a new category of material is created, which has several unique properties that overcome the disadvantages of primitive material and favors its use in different biomedical applications. The doping can enhance handling properties, angiogenic and osteogenic performance, and antimicrobial activity. Therefore, this review aims to summarize the effect of selected metal ion dopants into bioceramics and silicate-based BGs in bone tissue engineering. Furthermore, new applications for doped bioceramics and BGs are highlighted, including cancer treatment and drug delivery. 相似文献
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Zhencai Li Dacheng Zhou Lars R. Jensen Jianbei Qiu Yanfei Zhang Yuanzheng Yue 《Journal of the American Ceramic Society》2021,104(9):4471-4478
The transparent Er3+-Yb3+-doped fluoro-aluminosilicate glass-ceramic (GC) was prepared by melt-quenching. The crystal phase, morphology, and up-conversion (UC) luminescence of as-produced GC were characterized by X-ray diffraction, scanning electron microscopy, and fluorescence spectrophotometry, respectively. The results show that BaYF5 nanocrystals were uniformly distributed in the glass matrix of the as-produced GC. When the as-produced GC was subjected to heat treatment, the crystallinity was increased, but the crystal identity remains unchanged. Such heat-treatment doubled the intensity of the UC luminescence, and this enhancement was ascribed to the increased incorporation of both Er3+ and Yb3+ ions into the lower phonon energy environment of BaYF5 nanocrystals. Furthermore, the heat-treated GC was stable against further crystallization, and consequently its UC luminescence was stable at the application temperature. The heat-treated GC was found to possess an outstanding temperature-sensing capability. 相似文献
5.
深凹露天矿山由于其特殊的结构,爆破产生的炮烟扩散稀释较为困难,严重危害生产作业人员的生命安全与健康。基于实际矿山构建了深凹露天矿山的二维物理及数学模型,采用非稳态数值分析方法研究了不同爆破位置下,深凹露天矿山采坑内爆破炮烟的扩散规律。研究结果表明:不同爆破位置下,露天采坑内均出现复环流,爆破点位置是影响露天采坑内风流结构特征的重要因素;露天采坑内的炮烟最高浓度均随着时间变化而逐渐下降,但下降的速率逐步减小,呈现三个阶段的下降趋势;爆破位置位于背风侧时露天采坑内的炮烟最高浓度和降至安全浓度所需时间远高于迎风侧三个爆破位置;随着背风侧爆破点距采坑底部距离的减小,炮烟最高浓度及降至安全浓度所需时间先降低后增加,炮烟最高浓度及降至安全浓度所需时间随着迎风侧爆破位置距采坑底部距离的减小而增加。研究结果对于指导深凹露天矿山企业合理组织爆破后的生产作业和保障作业人员安全具有重要意义。 相似文献
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目的 从设计事理学视角,探讨儿童情感陪伴玩具的设计方法。方法 通过社会调研结合理论分析,提炼7~12岁城市留守儿童情感陪伴玩具中“事”的各外部因素与内部因素,建立合理的儿童情感陪伴玩具设计模型及评价体系。运用案例分析法,结合儿童情感陪伴玩具设计案例与实践,验证设计事理学在实际儿童情感陪伴玩具设计中的应用价值。结论 探索儿童情感陪伴玩具的设计路径,以Combot——具有情感陪伴与寓教于乐功能的儿童情感陪伴玩具为实践案例,证明了基于设计事理学的儿童情感陪伴玩具设计方法是有效可行的,可有效指导儿童玩具设计,满足父母与孩子的情感需求,促进儿童健康成长。 相似文献
7.
《Advanced Powder Technology》2022,33(8):103695
Fe(III) ion can strongly inhibit the sulphidation amine flotation of smithsonite. However, its modification mechanism on smithsonite surface is still obscure. In this work, a systematic study of the modification of Fe(III) ion on smithsonite (1 0 1) surface was performed using DFT calculation. The optimal number of H2O ligands for Fe(III) ion hydrates in aqueous conditions was probed, and [Fe(OH)2(H2O)4]+ and [Fe(OH)4]? were identified as the major modification species, then their adsorption and bonding mechanisms were further revealed by analyzing the frontier orbitals, density of state, Mulliken population, and electron density. The calculated adsorption structures were consistent with the former experiment, and we found the O site that bonded to the C atom on smithsonite surface was the most favorable position for [Fe(OH)2(H2O)4]+ and [Fe(OH)4]? adsorptions. Besides, their adsorption mechanisms on smithsonite surface were principally due to the combined effect of FeO bond and hydrogen bonding. Simultaneously, hydrogen bonding greatly enhanced the stability of the adsorption structures. Moreover, the dominant orbital contribution for the bonding of FeO was primarily due to the orbital hybridization between Fe 3d and O 2p orbitals. This work can help in deeper understanding of the depression of Fe(III) ion on the sulphidation amine flotation of smithsonite. 相似文献
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以H型垂直轴风力机及其内含圆柱形实体为研究对象,对NACA0018翼型的五叶片H型垂直轴风力机的气动性能进行数值模拟和实验验证。分析8种不同直径的内含圆柱体,在内含实体截面积占风轮迎风面积之比分别为21.2%、50.0%和76.9%时,风力机风能利用率的峰值分别下降8.04%、20.7%及74.3%。结果表明:随着内含实体直径的增大,风能利用率的峰值逐渐减小,开始较为缓慢,达到一定值时快速下降。小直径内含实体主要影响叶片在下风区的转矩,对风能利用率的影响较小,而大直径内含实体还会影响叶片在上风区的转矩,其风能利用率迅速减小。对于内含固定直径的实体,比如在现有建筑物外侧安装风力机时,其风轮半径的选择需综合考虑风能利用率和风力机的建造成本两方面的因素。研究结果可为建筑物与垂直轴风力机进行有效结合以提高风能的利用提供参考。 相似文献
10.
In the present work, the heating performance of a new system combined with a new modified baseboard radiator and fan coil is investigated. Using longitudinal fins with special geometry and also forced airflow at the end of the system causes that at the lower inlet water temperature compared with the conventional models, higher heat output rate be obtained. The heat output rate of the new modified system is obtained by experimental metrology based on the European Standard No. EN-442. Temperature and velocity distribution in the room space is done by simulation of the modified system in the Flovent software. Computational fluid dynamics (CFD) results are validated against experimental results and there is a good agreement between them. Also, the energy consumption of the system during the winter season is calculated in TRANSYS software. Experimental results show that the heat output rate of a new modified heating system with inlet water temperature in the range of 45–55°C is on average 4.17 times higher compared with the conventional model. CFD simulation also showed that the combined system provides good thermal comfort conditions. Energy consumption of the new system reduced about 13% compared with conventional models. 相似文献