Red-Blood-Cell-Membrane-Coated Metal-Drug Nanoparticles for Enhanced Chemotherapy

To overcome high toxicity, low bioavailability and poor water solubility of chemotherapeutics, a variety of drug carriers have been designed. However, most carriers are severely limited by low drug loading capacity and adverse side effects. Here, a new type of metal-drug nanoparticles (MDNs) was designed and synthesized. The MDNs self-assembled with Fe(III) ions and drug molecules through coordination, resulting in nanoparticles with high drug loading. To assist systemic delivery and prolong circulation time, the obtained MDNs were camouflaged with red blood cell (RBCs) membranes (RBCs@Fe-DOX MDNs) to improve their stability and dispersity. The RBCs@Fe-DOX MDNs presented pH-responsive release functionalities, resulting in drug release accelerated in acidic tumor microenvironments. The outstanding in vitro and in vivo antitumor therapeutic outcome was realized by RBCs@Fe-DOX MDNs. This study provides an innovative design guideline for chemotherapy and demonstrates the great capacity of nanomaterials in anticancer treatments.     

过氧化二碳酸双（2-乙基）己酯的合成研究

以氯甲酸(2-乙基)己酯为原料制备过氧化二碳酸双(2-乙基)己酯(EHP)，研究了加料方式、反应温度、反应时间、投料比等因素对产品的影响。结果表明：氯甲酸(2-乙基)己酯与过氧化钠的摩尔比为1：0．58～0．62，反应温度为15℃～20℃，反应时间为3～4小时，以异十二烷为溶剂，可以得到高效、无毒的EHP溶液。     

求解逆Goursat问题的变分迭代法

应用变分迭代法来求解一类逆Goursat问题,可以得到快速收敛于精确值的序列,计算结果说明了本方法的有效性.     

基于小波分析和遗传神经网络的模拟电路故障诊断方法*

针对BP网络极易收敛于局部极小点与过拟合等缺点,在构建小波神经网络的基础上,提出用遗传算法优化BP神经网络的模拟电路故障诊断方法.该方法使用小波作为预处理工具,经PCA分析和归一化后提取输出信号的能量信息作为特征向量,用遗传BP神经网络作为故障识别器,对模拟电路故障进行诊断.与传统BP神经网络相比较,结果表明,该方法可明显改善神经网络结构、提高故障诊断的精度和速度.     

车辆-轨道-桥梁空间耦合振动引起的环境振动

首先建立了车辆-无碴轨道-桥梁系统空间耦合振动模型,通过随机振动分析得到桥墩墩底反力,然后建立了土体-建筑物的三维有限元模型,并将以上得到的墩底反力作为土体-建筑物三维有限元模型的外部激励。分析结果表明,周围土体振动强度随距离的增加而减小,且都存在反弹区 周围建筑物的振动强度随桥墩距离的增大而减小,且在建筑物低层横向和竖向振动相差不大,但是到了高层处横向振动明显大于竖向振动。     

Effects of nonlinear strength parameters on stability of 3D soil slopes

Actual slope stability problems have three-dimensional(3D) characteristics and the soils of slopes have curved failure envelopes. This incorporates a power-law nonlinear failure criterion into the kinematic approach of limit analysis to conduct the evaluation of the stability of 3D slopes. A tangential technique is adopted to simplify the nonlinear failure criterion in the form of equivalent Mohr-Coulomb strength parameters. A class of 3D admissible rotational failure mechanisms is selected for soil slopes including three types of failure mechanisms: face failure, base failure, and toe failure. The upper-bound solutions and corresponding critical slip surfaces can be obtained by an efficient optimization method. The results indicate that the nonlinear parameters have significant influences on the assessment of slope stability, especially on the type of failure mechanism. The effects of nonlinear parameters appear to be pronounced for gentle slopes constrained to a narrow width. Compared with the solutions derived from plane-strain analysis, the 3D solutions are more sensitive to the values of nonlinear parameters.     

物联网智能终端适配中间件开发模式

针对目前大多数的智能终端应用开与服务开发,需针对终端不同种类、不同的操作系统等进行定制,存在开发周期长,成本高,增加了重复性劳动和资源浪费的问题,阐述并提出研发一款适合各类智能终端的物联网应用适配中间件,以匹配不同数据源和不同终端.研究了中间件的系统架构和技术架构,采用面向对象的思想,融合MVC(Model View Control),Adapter,Singleton等多种设计模式.智能终端中间件能够提高物联网领域行业应用能力,扩大物联网领域的接入渠道.     

视频监控与3DGIS的集成与应用

结合Skyline软件中的Video On Terrain技术提出了一种3DGIS与视频监控系统相集成的三维地面影像视频监控新方案,设计了3DGIS视频监控系统的软硬件框架和数据库,讨论了视频数据传输和编码、视频监控报警流程以及网络分析等关键技术,详细介绍了三维场景的创建过程,最后实现了视频监控与3DGIS集成的原型系统,并分析了系统集成的优势。