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1.
The germline carrier of the BRCA1 pathogenic mutation has been well proven to confer an increased risk of breast and ovarian cancer. Despite BRCA1 biallelic pathogenic mutations being extremely rare, they have been reported to be embryonically lethal or to cause Fanconi anemia (FA). Here we describe a patient who was a 48-year-old female identified with biallelic pathogenic mutations of the BRCA1 gene, with no or very subtle FA-features. She was diagnosed with ovarian cancer and breast cancer at the ages of 43 and 44 and had a strong family history of breast and gynecological cancers.  相似文献   
2.
We recently discovered a novel nargenicin A1 analog, 23-demethyl 8,13-deoxynargenicin (compound 9), with potential anti-cancer and anti-angiogenic activities against human gastric adenocarcinoma (AGS) cells. To identify the key molecular targets of compound 9, that are responsible for its biological activities, the changes in proteome expression in AGS cells following compound 9 treatment were analyzed using two-dimensional gel electrophoresis (2-DE), followed by MALDI/TOF/MS. Analyses using chemical proteomics and western blotting revealed that compound 9 treatment significantly suppressed the expression of cyclophilin A (CypA), a member of the immunophilin family. Furthermore, compound 9 downregulated CD147-mediated mitogen-activated protein kinase (MAPK) signaling pathway, including c-Jun N-terminal kinase (JNK) and extracellular signal-regulated protein kinase 1/2 (ERK1/2) by inhibiting the expression of CD147, the cellular receptor of CypA. Notably, the responses of AGS cells to CypA knockdown were significantly correlated with the anticancer and antiangiogenic effects of compound 9. CypA siRNAs reduced the expression of CD147 and phosphorylation of JNK and ERK1/2. In addition, the suppressive effects of CypA siRNAs on proliferation, migration, invasion, and angiogenesis induction of AGS cells were associated with G2/M cell cycle arrest, caspase-mediated apoptosis, inhibition of MMP-9 and MMP-2 expression, inactivation of PI3K/AKT/mTOR pathway, and inhibition of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) expression. The specific interaction between compound 9 and CypA was also confirmed using the drug affinity responsive target stability (DARTS) and cellular thermal shift assay (CETSA) approaches. Moreover, in silico docking analysis revealed that the structure of compound 9 was a good fit for the cyclosporin A binding cavity of CypA. Collectively, these findings provide a novel molecular basis for compound 9-mediated suppression of gastric cancer progression through the targeting of CypA.  相似文献   
3.
杨尚威 《中国油脂》2021,46(12):127-135
为研究不同品种核桃挥发性风味物质的差异和核桃品种的区分方法,以5种核桃为研究对象,采用气相离子迁移谱(GC-IMS)和电子鼻(E-nose)技术结合主成分分析(PCA)、线性判别分析(LDA)和聚类分析,对核桃挥发性风味物质的组成及品种差异进行了研究。结果表明:GC-IMS技术结合聚类分析和E-nose技术结合LDA分析均能有效区分核桃品种;采用GC-IMS技术从5种核桃中分离出73种挥发性成分,鉴定出其中19种物质,主要有醇类、酮类、醛类和酯类,其中乙醇、2-甲基丙醇、1-戊醇、3-甲基-3-丁烯-1-醇、正己醇、2-庚酮、戊醛、己醛、庚醛、壬醛、苯甲醛和乙酸乙酯是区分核桃品种的关键物质; E-nose分析结果表明,W3C、W5C、W1C和W6S传感器在区分核桃品种上有较大贡献,LDA由于考虑了组间差距,对于核桃品种的区分相较PCA更为明显;两种风味分析技术相比较,GC-IMS可对挥发性物质进行定性和定量检测,E-nose虽不能鉴定挥发性物质的具体种类,但样品处理简单,可实现品种的快速区分。  相似文献   
4.
ABSTRACT

The state-of-the-art article presents concepts of nanobelt nanofiller, inimitable properties of derived polymeric nanocomposite, applications, and outlook on challenges to gain next generation high-performance materials. Nanobelt is a one-dimensional nanostructured nanomaterial. Owing to minuscule size and high surface area, nanobelt possesses unique structural, optical, electronic, mechanical, and thermal characteristics. Nanobelt exists in various forms such as carbon nanobelt, polymer nanobelt, and inorganic. These nanobelts have been used to develop polymer/nanobelt nanocomposites. Homogeneous dispersion of nanobelt in polymer matrices is desirable to enhance the characteristics of polymer/nanobelt nanocomposite. Consequently, innovations in design, fabrication, and properties of various polymer/nanobelt nanocomposite are summarized. Applications of polymer/nanobelt nanocomposite are reviewed for Li-ion battery, supercapacitor, sensor, membrane, and biomedical arenas.  相似文献   
5.
大庆长垣喇萨杏油田经多年开发,已进入水驱、聚驱、三元复合驱并存阶段。注入溶液改变了储层的物理性质,地层水矿化度、含油饱和度、孔隙结构以及岩石润湿性等都会发生变化,不同的驱替方式导致了不同的储层地质特征。油层水淹后,电阻率、自然电位、微电极幅度差等测井响应的变化规律也不同。本文利用大庆油田丰富的密闭取芯检查井资料,系统的研究了化学驱后水淹层地质特征及测井响应特征分析,对提高水淹层测井解释的精度奠定了基础。  相似文献   
6.
All-solid-state lithium batteries(ASSLB) are promising candidates for next-generation energy storage devices.Nevertheless,the large-scale commercial application of high energy density AS S LB with the polymer electrolyte still faces challenges.In this study,a thin solid polymer composite electrolyte(SPCE) is prepared through a facile and cost-effective strategy with an infiltration of thermoplastic polyurethane(TPU),lithium salt(LiTFSI or LiFSI),and halloysite nanotubes(HNTs) in a porous framework of polyethylene separator(PE)(TPU-HNTs-LiTFSI-PE or TPU-HNTs-LiFSI-PE).The composition,electrochemical performance,and especially the effect of anions(TFSI~-and FSI~-) on cycling performance are investigated.The results reveal that the flexible TPU-HNTs-LiTFSI-PE and TPU-HNTs-LiFSI-PE with a thickness of 34 μm exhibit wide electrochemical windows of 4.9 and 5.1 V(vs.Li+/Li) at 60℃,respectively.Reduction in FSI~-tends to form more LiF and sulfur compounds at the interface between TPU-HNTs-LiFSI-PE and Li metal anode,thus enhancing the interfacial stability.As a result,cell composed of TPU-HNTs-LiFSI-PE exhibits a smaller increase in interfacial resistance of solid electrolyte interphase(SEI) with a distinct decrease in charge-transfer resistance during cycling.Li|Li symmetric cell with TPU-HNTs-LiFSI-PE could keep its stable overpotential profile for nearly 1300 h with a low hysteresis of approximately39 mV at a current density of 0.1 mA cm~(-2),while a sudden voltage rise with internal cell impedance-surge signals was observed within 600 h for cell composed of TPU-HNTs-LiTFSI-PE.The initial capacities of NCMITPU-HNTs-LiTFSIPEILi and NCMITPU-HNTs-LiFSI-PEILi cells were 149 and 114 mAh g~(-1),with capacity retention rates of 83.52% and89.99% after 300 cycles at 0.5 C,respectively.This study provides a valuable guideline for designing flexible SPCE,which shows great application prospect in the practice of ASSLB.  相似文献   
7.
吉远辉  陈俏  翁靖云 《化工学报》2021,72(1):508-520
探究聚合物辅料对难溶性药物结晶的影响机制,是指导无定形固体分散体制剂设计和制备中辅料筛选的关键。研究了不同因素(温度、搅拌速率、聚合物浓度、聚合物分子量和聚合物种类等)对阿司匹林晶体生长动力学的影响。首先,采用基于三种不同晶体生长机制的化学势梯度模型结合UNIQUAC活度系数模型,描述和预测了阿司匹林在不同条件下的结晶动力学。进一步分析了不同因素对晶体生长速率常数kt和结晶热力学推动力?μ的影响以及对阿司匹林结晶动力学的影响机制。结果表明,阿司匹林晶体生长速率随着结晶温度、聚合物浓度的增加而降低,随搅拌速率的增加而升高;聚乙烯吡咯烷酮(PVP K25)和羟丙基甲基纤维素(HPMC E3)显著抑制了阿司匹林的晶体生长,在PVP K25和HPMC E3水溶液体系下阿司匹林的晶体生长属于二维成核机制,在纯水和PEGs水溶液体系下晶体生长属于粗糙生长机制。所采用的化学势梯度模型能很好预测不同温度和搅拌速率下阿司匹林的结晶动力学,可有效减少实验所需的人力、物力和财力。研究可为固体分散体制剂制备中聚合物的筛选提供理论研究基础。  相似文献   
8.
以感官评分为评价指标,通过单因素实验研究不同参数对产品品质的影响,结合响应面试验设计优化产品最佳配方,并评定产品质量。结果表明,百香果果冻的最佳配方为:百香果汁添加量为100%,百香果皮添加量为22%,复合甜味剂白砂糖与蜂蜜质量比为3:1,复合甜味剂添加量为15%,复合凝胶剂卡拉胶与魔芋胶质量比为2:1,复合凝胶剂添加量为0.6%。最优条件下加工的百香果果冻外形整齐,晶莹剔透,呈金黄色,具有较好的弹性和咬劲,风味十足,感官评分可达91.17分,微生物指标符合国家标准,是一款营养、健康、安全的新型休闲食品,可为百香果产业发展和新型食品开发提供一定的理论参考。  相似文献   
9.
针对加大砂土强度的问题,采用水溶性聚合物对其进行改良,对不同砂土干密度、固化剂含量及养护时间的改良砂土进行了直接剪切试验,并对其黏聚力及内摩擦角进行分析。结果表明:水溶性聚合物改良的砂土剪切强度得到一定程度地提高,这是由于水溶性聚合物加固砂土试样,形成包裹颗粒并相互联系的弹性黏膜,从而增加了土体强度;当养护时间一定时,改良砂土的剪切强度随着固化剂含量增加而上升,试样黏聚力最高可达183.52 kPa;当固化剂含量一定时,改良砂土的剪切强度随着养护时间增加而增加,试样黏聚力最高可达200.19 kPa;剪切强度的大小与固化剂含量、养护时间、试样干密度大小呈正相关。水溶性聚合物溶液在砂土中形成的弹性黏膜包裹砂粒,填充砂土空隙,进而增强土颗粒间的相互作用,改善砂土的工程特性。  相似文献   
10.
In an effort to develop highly functionalized flame retardant materials, hybrid nanocoatings are prepared by alternately depositing a positively charged polyaniline (PANi) and negatively charged montmorillonite (MMT) using the layer-by-layer (LbL) assembly technique. Carbon nanotubes (CNTs) are employed in polymer nanocomposites as effective reinforcement, where nanotubes are stabilized in MMT aqueous solution. The 3D structure and high density of CNTs deposited in the PANi/CNTs-MMT multilayers produce thicker and heavier coatings in comparison to the LbL assemblies without CNTs. Vertical and horizontal flame testing show that the incorporation of CNTs improves fire resistance. Additionally, cone calorimetry reveals that stacking two nanomaterials (MMT and CNTs) in a single coating shows a significant reduction in peak heat release rate (up to 51%), total smoke release (up to 47%), and total heat release (up to 37%) for the polyurethane foam. The enhancement of flame retardancy is attributed to a synergistic effect; MMT serves as a physical barrier that retards the diffusion of heat and gas. The addition of CNTs strengthens the thermal stability and high char yield. These results, coupled with the simplicity with which the LbL deposition is applied, present a viable alternative to halogen-free flame retardant nanocoatings to natural and synthetic fibers.  相似文献   
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