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Alexandra Kodadová Zuzana Vitková Petra Herdová Anton Ťažký Jarmila Oremusová Daniel Grančai 《Drug development and industrial pharmacy》2015,41(7):1080-1088
This study deals with the formulation of natural drugs into hydrogels. For the first time, compounds from the sage essential oil were formulated into chitosan hydrogels. A sample preparation procedure for hydrophobic volatile analytes present in a hydrophilic water matrix along with an analytical method based on the gas chromatography coupled with the mass spectrometry (GC-MS) was developed and applied for the evaluation of the identity and quantity of essential oil components in the hydrogels and saline samples. The experimental results revealed that the chitosan hydrogels are suitable for the formulation of sage essential oil. The monoterpene release can be effectively controlled by both chitosan and caffeine concentration in the hydrogels. Permeation experiment, based on a hydrogel with the optimized composition [3.5% (w/w) sage essential oil, 2.0% (w/w) caffeine, 2.5% (w/w) chitosan and 0.1% (w/w) Tween-80] in donor compartment, saline solution in acceptor compartment, and semi-permeable cellophane membrane, demonstrated the useful permeation selectivity. Here, (according to lipophilicity) an enhanced permeation of the bicyclic monoterpenes with antiflogistic and antiseptic properties (eucalyptol, camphor and borneol) and, at the same time, suppressed permeation of toxic thujone (not exceeding its permitted applicable concentration) was observed. These properties highlight the pharmaceutical importance of the developed chitosan hydrogel formulating sage essential oil in the dermal applications. 相似文献
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为了成功预测竹林山煤矿综放高瓦斯矿井大采高工作面煤层瓦斯涌出量,以主采3号煤层为主要研究对象,针对3号煤层以往开采情况,通过布设测点测量其煤层瓦斯含量和了解相邻矿井瓦斯含量,采用分源预测法、回归法及统计法等预测方法得到了3号煤层瓦斯含量的分布规律,并绘制了3号煤层的瓦斯含量等值线图。对矿井不同生产时期的瓦斯含量进行预测,得到了生产前期、中期及后期采区的最大绝对瓦斯涌出量和最大相对瓦斯涌出量,说明了竹林山煤矿各个时期均属于高瓦斯矿井。 相似文献
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Prediction of methane adsorption content in continental coal-bearing shale reservoir using SLD model
Shale gas, as an important unconventional resource, has drawn global attention. It is mainly composed of adsorption gas and free gas. Adsorption gas content could play an important guiding role on both the selection of favorable perspective area and the exploration and exploitation of shale gas resources. In order to accurately measure adsorption gas content, a new approach was established to predict the adsorption isotherm of methane on shale. Based on the simplified local-density (SLD) method, both the adsorption isotherms of illite, illite/smectite mixed-layer, cholorite and type III kerogen and the total shale rock could be well fitted. The fitting results show good coincidences with the true experimental test data, which proves the method is reasonable and dependable and the prediction results are effective and credible. In addition, the good simulation results show that the SLD parameters can reflect the pore structure characteristics and corresponding adsorption characteristics of the shale samples, which can be used for the quantitative characterization of shale pore system. 相似文献
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This paper proposes a thermoelectric-assisted vapor compression cycle (TVCC) for applications in air-source heat pump systems which could enhance the heating capacity of the system. Performances of TVCC are calculated and then compared with that of basic vapor compression cycle (BVCC). The simulation results show that when coefficients of performance (COPs) of the two cycles are almost equal, the TVCC under maximum COP condition of the thermoelectric modules still performs better than BVCC by 13.0% in heating capacity through selecting the appropriate intermediate temperature. In addition, the TVCC can also achieve an improvement of 16.4%–21.7% in both the heating COP and capacity when compared with the BVCC with an assistant electric heater that is provided with the equivalent power input of thermoelectric heat exchanger. Thus, the TVCC could be beneficial to the applications in small heat pumps if there is always need for auxiliary electric heat. 相似文献
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分析了冶炼烟气制酸工艺的特点,介绍了由PROFIBUS-DP现场总线构建的冶炼厂烟气制酸监控系统,详细介绍了其硬件配置及相应的软件设计。 相似文献
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于立兴 《兵器材料科学与工程》2003,26(1):55-57
板厚为 5 5mm的 16Mn钢采用CO2 半自动气保焊建造大型转炉炉体的可能性和可靠性如何 ?目前尚缺少足够的试验数据。为了给转炉工程的施工焊接提供可靠数据 ,确保焊接质量 ,对板厚 5 5mm16Mn钢CO2 半自动的焊接性能进行了一系列的试验研究 相似文献
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大牛地气田为低渗-致密气田,因存在启动压力梯度等因素,修正等时试井曲线按常规方法处理出现异常,无法准确获取气井的产能方程.采用LIT法和异常曲线校正法对气田异常试井资料进行了重新处理,最终获得气井产能方程,为同类气藏产能试井可能出现的异常资料处理解释探索了新的途径. 相似文献