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排序方式: 共有8911条查询结果,搜索用时 15 毫秒
1.
原油、天然气长输管道建设完工后,必须要进行管径通径检测,其目的在于发现施工过程可能产生的管道异常变形。我们以检测管径原始尺寸完整性为目标,进行管道变形缺陷数字化建模、非接触通径检测器运行过程控制、制造工艺、系统优化等方面的研究,基于激光传感器等技术的结合,研发了新型非接触式智能管道通径检测器,弥补传统的接触式(机械式)通径检测器运行状态不稳定造成的数据信号失真、探头易磨损、维护费用高等不足之处,提高了管道内壁变形缺陷识别、数据采集以及变形量大小、变形点位置分析处理的准确性,据此进行开挖作业,对管道及时进行修整,消除事故隐患,为油气长输管道的安全生产运行提供保障。本文重点介绍了该非接触式智能管道通径检测器的工作原理、结构特点的设计分析。 相似文献
2.
Yan He Kangren Kong Zhengxi Guo Weifeng Fang Zaiqiang Ma Haihua Pan Ruikang Tang Zhaoming Liu 《Advanced functional materials》2021,31(26):2101291
Sensitivity and multi-directional motivation are major two factors for developing optimized humidity-response materials, which are promising for sensing, energy production, etc. Organic functional groups are commonly used as the water sensitive units through hydrogen bond interactions with water molecules in actuators. The multi-coordination ability of inorganic ions implies that the inorganic ionic compounds are potentially superior water sensitive units. However, the particle forms of inorganic ionic compounds produced by classical nucleation limit the number of exposed ions to interact with water. Recent progress on the inorganic ionic oligomers has broken through the limitation of classical nucleation, and realized the molecular-scaled incorporation of inorganic ionic compounds into an organic matrix. Here, the incorporation of hydrophilic calcium carbonate ionic oligomers into hydrophobic poly(vinylidene fluoride) (PVDF) is demonstrated. The ultra-small calcium carbonate oligomers within a PVDF film endow it with an ultra-sensitive, reversible, and bidirectional response. The motivation ability is superior to other bidirectional humidity-actuators at present, which realizes self-motivation on an ice surface, converting the chemical potential energy of the humidity gradient from ice to kinetic energy. 相似文献
3.
Nianxiu Duan Junjun Li Sha Song Feng Wang Yiwei Yang Di Nie Caifen Wang Yingjie Sheng Yali Tao Jie Gao Can Xu Yan Wei Yong Gan 《Advanced functional materials》2021,31(46):2100605
Tumor-specific enhanced delivery of chemotherapeutics and modulators to tumor cells and activated pancreatic stellate cells (aPSCs), respectively, represents safer and more effective therapy for pancreatic cancer. Herein, a membrane type 1-matrix metalloproteinase (MT1-MMP)-cleavable spacer is used to assemble low-density cRGDfK onto thermosensitive liposomes loaded with phosphorylated calcipotriol (PCAL) and doxorubicin (DOX), yielding MR-T-PD. The liposome-linked cRGDfK prodrug on MR-T-PD surface is first activated by MT1-MMP, which is selectively expressed on tumor endothelial cells, to release cRGDfK. The free cRGDfK specifically promotes tumor angiogenesis, leading to 3.4-fold higher accumulation and a wider distribution of MR-T-PD in tumors. Furthermore, MR-T-PD rapidly releases PCAL and DOX into the interstitium under heat treatment. The released DOX enters tumor cells to induce apoptosis, whereas the PCAL prodrug is converted to CAL by alkaline phosphatase on the surface of aPSCs; CAL can then enter aPSCs to induce quiescence and promote the antitumor effect of DOX. Finally, by enhancing the exposure of DOX and CAL to tumor cells and aPSCs, respectively, in a tumor-specific manner, MR-T-PD exerts superior efficacy (a 5.9-fold decrease in tumor weight) without causing additional side effects. Overall, this prodrug-based smart liposome system represents a promising paradigm for pancreatic cancer therapy. 相似文献
4.
Peter J. Jervis Carolina Amorim Teresa Pereira Jos A. Martins Paula M. T. Ferreira 《International journal of molecular sciences》2021,22(5)
Supramolecular peptide hydrogels are gaining increased attention, owing to their potential in a variety of biomedical applications. Their physical properties are similar to those of the extracellular matrix (ECM), which is key to their applications in the cell culture of specialized cells, tissue engineering, skin regeneration, and wound healing. The structure of these hydrogels usually consists of a di- or tripeptide capped on the N-terminus with a hydrophobic aromatic group, such as Fmoc or naphthalene. Although these peptide conjugates can offer advantages over other types of gelators such as cross-linked polymers, they usually possess the limitation of being particularly sensitive to proteolysis by endogenous proteases. One of the strategies reported that can overcome this barrier is to use a peptidomimetic strategy, in which natural amino acids are switched for non-proteinogenic analogues, such as D-amino acids, β-amino acids, or dehydroamino acids. Such peptides usually possess much greater resistance to enzymatic hydrolysis. Peptides containing dehydroamino acids, i.e., dehydropeptides, are particularly interesting, as the presence of the double bond also introduces a conformational restraint to the peptide backbone, resulting in (often predictable) changes to the secondary structure of the peptide. This review focuses on peptide hydrogels and related nanostructures, where α,β-didehydro-α-amino acids have been successfully incorporated into the structure of peptide hydrogelators, and the resulting properties are discussed in terms of their potential biomedical applications. Where appropriate, their properties are compared with those of the corresponding peptide hydrogelator composed of canonical amino acids. In a wider context, we consider the presence of dehydroamino acids in natural compounds and medicinally important compounds as well as their limitations, and we consider some of the synthetic strategies for obtaining dehydropeptides. Finally, we consider the future direction for this research area. 相似文献
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6.
蒙特卡洛法需使用大量电网抽样数据,花费的风险评估时间长,提出一种改进蒙特卡洛法实现高效智能电网实时运行风险评估。从多方面考虑,构建智能电网风险评价指标体系,明确蒙特卡洛法存在抽样次数多及方差系数大的问题;将交叉熵重要抽样法与分散抽样法相结合,构建近似函数,令原本电网中微小概率事件转换为大概率事件,减少算法抽样次数和方差系数,提高算法的计算效率。实验表明,所提方法能够有效识别正常状态下及元件失效条件下的电网实时运行风险,并通过失效线路负荷转移的方式有效降低了智能电网实时运行风险。 相似文献
7.
智能服装的发展得益于社会经济文化高速前进的推动,是数字化时代的必然需求。从构成智能服装系统的智能纱线、传感器、连接技术、供电方式和服装材料等五个要素出发,论述了智能服装开发的关键技术发展现状,介绍了智能服装在体育、军事和医疗领域的应用进展,结合时代需求分析了智能服装发展所遇到的问题。未来,通过压电材料、柔性技术材料和服用性能较好的电子设备与智能安全的集成和连接技术结合,会设计出更加安全高效且适合人类的高性能智能科技服装。 相似文献
8.
采用料浆烧结法在TZM钼合金表面制备Mo层,再通过包埋渗法制得双层结构的MoSi2厚涂层。利用内热法在大气环境下测试了钼合金Si-Mo涂层在1 600 ℃下的高温抗氧化性能。结果表明,涂层由多孔MoSi2外层和致密MoSi2内层组成,Mo粉细化对涂层组织致密化和高温抗氧化性能提升有益,平均粒度9.8 μm和2.2 μm的Mo粉制备的涂层在1 600 ℃下的高温抗氧化寿命分别为5.1 h和14.8 h,高温氧化后涂层结构转变为SiO2氧化层-多孔MoSi2层-致密层-Mo5Si3层。随着氧化持续进行,SiO2层和Mo5Si3层不断增厚,而MoSi2层持续减薄并转化为Mo5Si3,硅元素的持续贫化导致涂层最终失效。 相似文献
9.
为了解决医院耗材数量多、种类复杂导致的科室耗材管理琐碎繁杂问题。本文提出基于人工智能调度及智能柜分类管理的医院科室耗材精细化管理方法。利用大数据方法建立医院科室耗材数据库,分段拟合控制数据库信息,通过空间资源优化分配方法重组数据,构造医院科室耗材的智能柜,智能分类识别医院科室耗材,提取医院科室耗材信息的统计特征量,规则化调度和自动更新医院科室耗材管理信息,实现医院科室耗材的精细化管理和评估。仿真结果表明,本文方法可实现医院科室耗材精细化管理,分类性能较好,精细化水平较高。 相似文献
10.
常规的管线布置优化方法难以在优化过程中得到全局搜索的最优解,导致安全性能无法得到保障,因此面向智慧小镇建设设计一个新的机房电气管线多目标优化布置方法。设置电气管线约束条件,将电压均值、单位时间内电流量、电气管线损耗恢复能力作为目标函数。优化管线布置全局搜索,使用交叉操作的方式不断得到更优解。建立多目标优化电气管线模型,得到电气管线多目标优化的数学模型。通过实验数据可知,该管线布置方法在算法测试中优于常规的3种算法,且在安全性能的检测中只与标准最优值相差6.22×104,3个常规方法与标准最优值的差距为6.813×104、7.6×104、8.32×104,因此可知该多目标优化的管线布置方法可以得到更优解。 相似文献