两种混合单元混合机理的数值模拟

为了研究SV型和SX型混合单元在全静态乳化器的混合机理,使用群体平衡模型对乳化器内部流场进行模拟分析。结果表明,SV型与SX型混合单元的混合机理是油相与水相材料通过混合单元时其空间流动方向改变,在流场内形成大量的漩涡,从而达到乳化的目的;通过比较流体在经过SV型和SX型混合单元后的水相索特平均直径(d_(32)),得出SV型混合单元的乳化效果更强,但同时消耗更多的能量,压降更大。     

高强化柴油机冷却系统电控化设计仿真及试验研究

针对传统冷却系统与柴油机冷却需求不匹配的问题，进行了冷却系统电控化设计仿真研究。基于Simulink软件设计了电控冷却系统仿真模型，提出了电控冷却控制策略，并开展了变柴油机工况条件下电控冷却控制策略验证仿真。对传统冷却部件进行电控化改造（电控海水泵、电控淡水泵和电子节温器），搭建电控冷却系统试验台架，通过试验分析了电控冷却对柴油机耗油率和热平衡的影响，结果表明：相对于传统冷却系统，电控冷却系统在900 r/min、负荷率30%，1 200 r/min、负荷率60%，1 500 r/min、负荷率90%这3个工况点的耗油率分别降低9.4 g/（kW·h）、6.8 g/（kW·h）和3.9 g/（kW·h），燃油经济性和热量分配得到改善。     

Omega-6支撑身体，Omega-3支撑大脑：均衡摄入对儿童大脑发育的影响（网络首发、推荐阅读）

人体大脑和身体的发育，需要从食物中摄取均衡的营养物质。人类大脑是区分人类和其他动物的特征。食物中的必需脂肪酸是机体组织结构和功能的必要组成部分。Omega-6（O6）亚油酸（LA6）是皮肤组织的组成成分，且是炎症、血栓形成、免疫和其他信号分子的前体；Omega-3（O3）α-亚麻酸（ALA3），特别是其长链代谢产物——二十二碳六烯酸（DHA3），是大脑、视网膜和部分神经组织中的关键组分。从富含LA6脂肪酸（缺乏O3脂肪酸）的植物籽中提取出的廉价而优质油脂，是20世纪的西方国家食品工业生产的主要脂肪来源。在代谢通路中，高浓度的LA6脂肪酸可拮抗O3脂肪酸代谢，造成O3脂肪酸不足，因此，在给怀孕动物的饲料中，只提供富含LA6但缺乏O3脂肪酸的油脂作为唯一的脂肪来源，会导致幼崽大脑发育不良。过去20~30年的研究表明，低含量LA6且含DHA3的油脂可改善大脑的功能。近年来的研究较多集中在营养因素对大脑发育的影响，最新研究数据表明，脂肪酸平衡对营养不良儿童的大脑发育尤为重要。世界卫生组织（WHO）越来越重视大脑的营养健康，通过其下属的食品法典委员会，建议用于治疗严重急性营养不良儿童的即食治疗食品中，使用含有均衡脂肪酸组成/构成的脂肪。同样，脂肪酸均衡对老年人可能也很重要。目前，业界已经有了调整油脂成分的方法，以确保脂肪酸均衡，从而维持人体整个生命周期的大脑健康。     

Form selection of concomitant polymorphs: A case study informed by crystallization kinetics modeling

Molecular mechanisms and process kinetics of crystallizing concomitant polymorphs remain poorly understood. Solvent-mediated phase transformation and concomitant crystallization are difficult to be distinguished in practice, as multiple forms can be detected at the same time. Herein, we developed a population balance model to simulate a concomitant crystallization process of two polymorphs of tolfenamic acid. Our kinetic modeling aims to understand concomitant crystallization and help guide form selection of such a molecular system. Crystallization kinetics of ethanolic solutions were uncovered from induction time measurements, as well as seeded and unseeded crystallization experiments. Experimental and simulation results demonstrate that the stable form I crystallizes concomitantly with the metastable form II. The faster growing form II results in an intermediate decline in the composition of form I in crystallized samples, a characteristic feature of the concomitantly crystallized system. A four-quadrant scheme of attainable polymorph outcome was simulated under various crystallization conditions.     

菌酶协同改善花生粕的饲用品质

花生粕是重要的蛋白饲料原料，但由于其氨基酸不平衡，特别是精氨酸与赖氨酸比例严重失衡（精氨酸与赖氨酸含量比值在3~4，理想的精氨酸与赖氨酸含量比值为1.0），限制了其在动物养殖中的应用。研究了复合酶预处理结合乳酸菌发酵花生粕对其品质的改善。结果表明：经菌酶协同处理后，花生粕粗蛋白质含量由46.4%提高至506%，大分子蛋白明显降解为小分子蛋白，酸溶蛋白质含量由2.3%提高至17.8%，多肽含量由1.6%提高至15.7%，蛋氨酸和赖氨酸含量分别提高了77.1%和42.0%，精氨酸降解率为18.7%，精氨酸与赖氨酸含量比值从3.7降低至2.1，总酸含量由06%提高到4.7%，其中乳酸含量由0.64 mg/g提高至14.63 mg/g。菌酶协同处理后的花生粕抗氧化性明显增强，其中每克菌酶协同处理后的花生粕对羟自由基的清除能力与171.6 mg VC相当，比花生粕（与47.6 mg VC相当）提高了2.6倍。     

Human DDX17 Unwinds Rift Valley Fever Virus Non-Coding RNAs

Rift Valley fever virus (RVFV) is a mosquito-transmitted virus from the Bunyaviridae family that causes high rates of mortality and morbidity in humans and ruminant animals. Previous studies indicated that DEAD-box helicase 17 (DDX17) restricts RVFV replication by recognizing two primary non-coding RNAs in the S-segment of the genome: the intergenic region (IGR) and 5′ non-coding region (NCR). However, we lack molecular insights into the direct binding of DDX17 with RVFV non-coding RNAs and information on the unwinding of both non-coding RNAs by DDX17. Therefore, we performed an extensive biophysical analysis of the DDX17 helicase domain (DDX17_135–555) and RVFV non-coding RNAs, IGR and 5’ NCR. The homogeneity studies using analytical ultracentrifugation indicated that DDX17_135–555, IGR, and 5’ NCR are pure. Next, we performed small-angle X-ray scattering (SAXS) experiments, which suggested that DDX17 and both RNAs are homogenous as well. SAXS analysis also demonstrated that DDX17 is globular to an extent, whereas the RNAs adopt an extended conformation in solution. Subsequently, microscale thermophoresis (MST) experiments were performed to investigate the direct binding of DDX17 to the non-coding RNAs. The MST experiments demonstrated that DDX17 binds with the IGR and 5’ NCR with a dissociation constant of 5.77 ± 0.15 µM and 9.85 ± 0.11 µM, respectively. As DDX17_135–555 is an RNA helicase, we next determined if it could unwind IGR and NCR. We developed a helicase assay using MST and fluorescently-labeled oligos, which suggested DDX17_135–555 can unwind both RNAs. Overall, our study provides direct evidence of DDX17_135–555 interacting with and unwinding RVFV non-coding regions.     

Mechanistic Studies on Trichoacorenol Synthase from Amycolatopsis benzoatilytica

Isotopic labeling experiments performed with a newly identified bacterial trichoacorenol synthase established a 1,5-hydride shift occurring in the cyclization mechanism. During EI-MS analysis, major fragments of the sesquiterpenoid were shown to arise via cryptic hydrogen movements. Therefore, the interpretation of earlier results regarding the cyclization mechanism obtained by feeding experiments in Trichoderma is revised.     

全局力平衡PDC钻头布齿优化设计

针对聚晶金刚石复合片(PDC)钻头在钻井破岩过程中因受力不平衡，导致钻井倾斜、井径扩大、钻头产生横向振动和涡动，造成钻头早期失效的问题，基于已有PDC钻头切削力学知识，构建了PDC钻头弯曲力矩及全局力平衡布齿优化设计模型，并提出模型求解方法。布齿设计实例结果表明，采用全局力平衡布齿设计方法得到的布齿结构可使PDC钻头在不同进尺条件下均能保持全局力平衡状态，尤其低进尺（小于1 mm）时的力平衡状态得到极大改善，提高了PDC钻头的钻井稳定性，对于改善钻头受力、提升钻头使用寿命、提高钻井质量与效率具有重要意义。     

Strategic Planning for Employment Self-Containment in Metropolitan Sub-Regions

Metropolitan strategic plans often focus on strengthening local employment opportunities to address the congestion and commuting issues threatening city sustainability. The success of such strategies relies on a more equitable distribution of jobs between sub-regions and can be comparatively benchmarked through one of the three related measures of employment self-sufficiency, self-containment or jobs-housing balance. However, in practice, planning policy implementation to meet these targets seldom reduces automobile commuting. This paper investigates self-containment across a range of occupation and industry types to highlight large differences in commuting and employment patterns through a case study of Perth’s Northwest sub-region, Western Australia. Its findings suggest the application of current sub-regional policy and targets within Perth may reinforce the wage and skill disadvantage of outer metropolitan sub-regions over the inner core. It recommends a more nuanced understanding of these measures taking into account the complex dynamics of both employment opportunities and commuting patterns across sub-regions of a city.     

煤矿主提升机平衡尾绳更换工艺的改进

更换煤矿主提升机平衡尾绳是煤矿重大检修项目之一,原施工方案为两条平衡尾绳同时更换,存在较多不合理之处,改进为以新绳带旧绳、单绳依次更换的方案,实现了安全、快捷地更换平衡尾绳,同时减少施工对矿井生产的影响,提高煤矿经济效益。