心源性猝死一级预防植入心律转复除颤器前非持续室性心动过速与植入后恰当治疗的关系

目的探讨植入型心律转复除颤器(implantable cardioverter defibrillator,ICD)用于心源性猝死一级预防时,植入前发生非持续性室性心动过速(non-sustained ventricular tachycardia,NSVT)与植入后ICD恰当治疗的关系。方法本研究为单中心回顾性队列研究,连续纳入2006年1月至2017年12月在北京协和医院住院植入ICD用于一级预防的心脏病患者,患者在住院期间ICD植入前均完善Holter检查。根据Holter检查是否出现NSVT,将患者分为NSVT组及无NSVT组。门诊或电话随访至2018年8月,随访事件包括全因死亡、植入后ICD放电治疗及抗心动过速起搏(antitachycardia pacing,ATP)治疗情况。结果纳入60例符合入选和排除标准的患者,随访时间37 (14～61)个月,KaplanMeier生存曲线及Log-Rank检验提示,NSVT组与无NSVT组相比,全因死亡率无统计学差异(P=0. 108),NSVT组恰当治疗的风险高于无NSVT组(P=0. 033),NSVT和左心室射血分数与ICD恰当治疗独立相关(NSVT:HR=5. 099,95%CI:1. 399～18. 588,P=0. 014;左心室射血分数:HR=1. 077,95%CI:1. 013～1. 145,P=0. 018)。结论 ICD一级预防患者植入前出现NSVT提示接受ICD恰当治疗的风险增加。     

Lessons from a Minimal Genome: What Are the Essential Organizing Principles of a Cell Built from Scratch?

One of the primary challenges facing synthetic biology is reconstituting a living system from its component parts. A particularly difficult landmark is reconstituting a self-organizing system that can undergo autonomous chromosome compaction, segregation, and cell division. Here, we discuss how the syn3.0 minimal genome can inform us of the core self-organizing principles of a living cell and how these self-organizing processes can be built from the bottom up. The review underscores the importance of fundamental biology in rebuilding life from its molecular constituents.     

成品油长输管道泄漏事故树风险分析

分析了某在建成品油长输管道投运后可能导致泄漏事故的诸因素,建立了泄漏事故树模型。通过泄漏事故树的最小径集以及基本事件的结构重要度对泄漏事件做了定性分析,识别引起管道泄漏的主要因素,提出了安全防范措施,为更好地实施长输管道安全管理提供重要依据。     

旧有建筑安全隐患及故障树分析方法

旧有建筑在许多方面存在安全隐患,运用定性和定量的方法分析旧有建筑安全隐患是城市防灾的重要课题之一。故障树分析方法在许多工业领域的成功运用,为它用于旧有建筑安全事故隐患分析提供了可能性。运用该方法分析了旧有建筑火灾隐患,并对旧有建筑安全评价的发展方向做出预测。     

Fabrication of cancellous-bone-mimicking β-tricalcium phosphate bioceramic scaffolds with tunable architecture and mechanical strength by stereolithography 3D printing

It is highly challenging to fabricate bioceramic scaffolds mimicking architecture and mechanical strength of cancellous bone. Gyroid structure, which is based on triply periodic minimal surface, highly resembles the architecture of cancellous bone. Herein, β-tricalcium phosphate (β-TCP) bioceramic scaffolds with gyroid structure were fabricated by stereolithography (SLA) 3D printing. The SLA 3D printing ensured high precision of ceramic part. The porosity (51–87%), pore size (250 – 2400 µm), pore wall thickness (< 300 µm) and compressive strength (0.6 – 16.8 MPa) of gyroid bioceramic scaffolds were readily adjusted to match various sites of cancellous bone. The gyroid bioceramic scaffolds were more favorable for cell proliferation than the grid-like bioceramic scaffolds. The cancellous-bone-mimicking gyroid bioceramic scaffolds with tunable architecture and mechanical strength were expected to efficiently repair the target bone defects.     

结合特征学习的粒子群求解极小碰集方法

基于模型诊断中的极小碰集问题是人工智能领域的一个重要课题,现实中很多实际问题都可以转化为极小碰集问题,如老师与课程问题,极小覆盖集问题等.通过对极小碰集问题特征的研究,本文结合粒子群优化求解极小碰集的算法提出了一个新的算法,来指导极小碰集的求解:引入学习机制,减少极小碰集求解中对无解空间的搜索;加入翻转策略,来加速极小碰集有解空间中的求解.实验结果表明本文提出的算法在求解极小碰集问题上的效率有明显提高.     

一类新的 pqr长2阶广义分圆序列的线性复杂度

具有良好随机性质的伪随机序列在流密码和通信领域中有着广泛的应用。本文构造出一类新的长为pqr的2阶广义分圆序列,并且计算其线性复杂度和极小多项式。结果显示这种序列具有高线性复杂度。