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1.
提出适用于装配式大跨度组合框架结构的钢管混凝土柱-混合梁节点. 为了研究节点的抗震性能及受力机理,对2个足尺中柱节点试件进行低周往复加载试验. 2个试件分别采用混合梁端型钢翼缘削弱式(RBS)节点以及梁端普通型钢节点. 对2个节点的破坏形态、耗能能力、承载能力、延性以及混合梁的应变分布规律进行对比分析. 试验结果表明,对梁端型钢翼缘的削弱处理可以有效促进试件在翼缘削弱区形成塑性铰,避免梁端焊缝的脆性破坏. 相比型钢未经处理的节点,翼缘削弱节点展现出更好的延性和耗能能力;梁底附加钢筋屈服后的黏结滑移会影响节点的耗能能力,在锚固长度满足规范要求的前提下,应适当增加其配筋率,以防止过早出现附加钢筋屈服后的黏结滑移.  相似文献   
2.
Apical membrane antigen 1 is a microneme protein which plays an indispensable role during Apicomplexa parasite invasion. The detailed mechanism of AMA-1 molecular interaction with its receptor on bovine erythrocytes has not been completely defined in Babesia bovis. This study was focused on identifying the minimum B. bovis AMA-1-derived regions governing specific and high-affinity binding to its target cells. Different approaches were used for detecting ama-1 locus genetic variability and natural selection signatures. The binding properties of twelve highly conserved 20-residue-long peptides were evaluated using a sensitive and specific binding assay based on radio-iodination. B. bovis AMA-1 ectodomain structure was modelled and refined using molecular modelling software. NetMHCIIpan software was used for calculating B- and T-cell epitopes. The B. bovis ama-1 gene had regions under functional constraint, having the highest negative selective pressure intensity in the Domain I encoding region. Interestingly, B. bovis AMA-1-DI (100YMQKFDIPRNHGSGIYVDLG119 and 120GYESVGSKSYRMPVGKCPVV139) and DII (302CPMHPVRDAIFGKWSGGSCV321)-derived peptides had high specificity interaction with erythrocytes and bound to a chymotrypsin and neuraminidase-treatment sensitive receptor. DI-derived peptides appear to be exposed on the protein’s surface and contain predicted B- and T-cell epitopes. These findings provide data (for the first-time) concerning B. bovis AMA-1 functional subunits which are important for establishing receptor-ligand interactions which could be used in synthetic vaccine development.  相似文献   
3.
孙玉明  徐蒙  李文慧  王静  张华  王玉林 《质谱学报》2021,42(6):1100-1112
建立了高效液相色谱-高分辨质谱法分析鉴定拉萨大黄化学成分。选用Agilent Zorbax SB-C18柱(150 mm×4.6 mm×5 μm),以乙腈和水为流动相进行梯度洗脱,流速0.5 mL/min;采用电喷雾离子源,在正、负离子模式下对拉萨大黄提取物进行一级和多级全扫描质谱分析。综合分析化合物的色谱和质谱行为,并结合对照品、文献和数据库等相关数据鉴定化合物。在负离子模式下,鉴定出63种化合物;正离子模式下,鉴定出54种化合物。所检测到的化合物包括22种鞣质类、28种茋类、6种黄酮类、3种苯丙酸类、2种苯丁酮类和2种有机酸类,其中有53种化合物为在该药材中首次发现,且未发现蒽醌类成分。该方法快速、灵敏,不仅提高了拉萨大黄复杂基质中微量化合物的鉴定效率,同时实现了对拉萨大黄提取物中不同类型化合物的分析鉴别,为进一步阐明拉萨大黄的药效物质基础及质控标准提供了科学依据。  相似文献   
4.
以玉米淀粉为原料,用流变分析、食品物性分析、差示扫描量热分析、低场核磁共振成像分析等研究冷藏过程中不同含量(相对玉米淀粉干基质量的1%、3%、5%和7%)皂荚糖胶对玉米淀粉老化特性的影响。动态流变时间扫描结果表明:随着老化时间的延长,玉米淀粉的弹性模量增加,皂荚糖胶的加入使复配体系弹性模量的变化率减小,一定程度上抑制玉米淀粉的短期老化;凝胶强度实验表明:随着冷藏时间的延长,玉米淀粉凝胶体系的硬度值增加,皂荚糖胶的加入使玉米淀粉形成质地更柔软的凝胶,硬度值明显降低;差示扫描量热测定结果表明:随着皂荚糖胶含量的增加,复配体系的老化率逐渐减小。用低场核磁水分运动性实验方法,通过5%皂荚糖胶加入前后淀粉凝胶中自由水、结合水和不易流动水含量的对比证实该胶对凝胶的水分分布有较大的影响;该研究能进一步丰富植物胶体对淀粉老化性能影响的理论。  相似文献   
5.
大庆长垣喇萨杏油田经多年开发,已进入水驱、聚驱、三元复合驱并存阶段。注入溶液改变了储层的物理性质,地层水矿化度、含油饱和度、孔隙结构以及岩石润湿性等都会发生变化,不同的驱替方式导致了不同的储层地质特征。油层水淹后,电阻率、自然电位、微电极幅度差等测井响应的变化规律也不同。本文利用大庆油田丰富的密闭取芯检查井资料,系统的研究了化学驱后水淹层地质特征及测井响应特征分析,对提高水淹层测井解释的精度奠定了基础。  相似文献   
6.
针对深度确定性策略梯度算法(DDPG)收敛速度比较慢,训练不稳定,方差过大,样本应用效率低的问题,提出了一种基于随机方差减小梯度方法的深度确定性策略梯度算法(SVR-DDPG)。该算法通过利用随机方差减小梯度技术(SVRG)提出一种新的创新优化策略,将之运用到DDPG算法之中,在DDPG算法的参数更新过程中,加入了随机方差减小梯度技术,利用该方法的更新方式,使得估计的梯度方差有一个不断减小的上界,令方差不断缩小,从而在小的随机训练子集的基础上找到更加精确的梯度方向,以此来解决了由近似梯度估计误差引发的问题,加快了算法的收敛速度。将SVR-DDPG算法以及DDPG算法应用于Pendulum和Mountain Car问题,实验结果表明,SVR-DDPG算法具有比原算法更快的收敛速度,更好的稳定性,以此证明了算法的有效性。  相似文献   
7.
The effect of dry and wet ball milling of LiFe5O8 ferrite powder on the microstructure and electromagnetic properties of ferrite ceramics was studied using XRD analysis, scanning electron microscopy, dilatometry, thermogravimetry, calorimetry, and measurement of specific magnetization and electrical resistance. The sintering temperature was 1050 °C; the sintering time was 2 h. It was found that ferrite fabricated from dry-milled powder exhibits an ordered α-LiFe5O8 phase with bulk density of 91%. Its saturation magnetization and Curie temperature are 55 emu/g and 628°С, respectively. Specific electrical resistance is 4?106 Ω cm. Wet milling in isopropyl alcohol causes formation of a disordered β-LiFe5O8 phase. Ceramics produced by this method shows higher bulk density (97%) and low porosity, and an order of magnitude lower resistivity. Its saturation magnetization and Curie temperature are 51 emu/g and 607°С, respectively.  相似文献   
8.
In this work, we developed a novel system of isovalent Zr4+ and donor Nb5+ co-doped CaCu3Ti4O12 (CCTO) ceramics to enhance dielectric response. The influences of Zr4+ and Nb5+ co-substituting on the colossal dielectric response and relaxation behavior of the CCTO ceramics fabricated by a conventional solid-phase synthesis method were investigated methodically. Co-doping of Zr4+ and Nb5+ ions leads to a significant reduction in grain size for the CCTO ceramics sintered at 1060 °C for 10 h. XRD and Raman results of the CaCu3Ti3.8-xZrxNb0.2O12 (CCTZNO) ceramics show a cubic perovskite structure with space group Im-3. The first principle calculation result exhibits a better thermodynamic stability of the CCTO structure co-doped with Zr4+ and Nb5+ ions than that of single-doped with Zr4+ or Nb5+ ion. Interestingly, the CCTZNO ceramics exhibit greatly improved dielectric constant (~105) at a frequency range of 102–105 Hz and at a temperature range of 20–210 °C, indicating a giant dielectric response within broader frequency and temperature ranges. The dielectric properties of CCTZNO ceramics were analyzed from the viewpoints of defect-dipole effect and internal barrier layer capacitance (IBLC) model. Accordingly, the immensely enhanced dielectric response is primarily ascribed to the complex defect dipoles associated with oxygen vacancies by co-doping Zr4+ and Nb5+ ions into CCTO structure. In addition, the obvious dielectric relaxation behavior has been found in CCTZNO ceramics, and the relaxation process in middle frequency regions is attributed to the grain boundary response confirmed by complex impedance spectroscopy and electric modulus.  相似文献   
9.
《Ceramics International》2021,47(24):34278-34288
Materials exhibiting colossal dielectric constant are the most sought-after materials due to their variety of applications in various electronics industries. NiFe2O4 and LaFeO3 belonging to the spinel and perovskite structures, respectively, were coupled into a nanocomposite by adapting a one-pot sol-gel synthesis. The ratio of NiFe2O4:LaFeO3 was varied and the synthesized materials were studied for their dielectric behaviors. Interestingly, among the samples studied, the nanocomposite with the ratio of 1:2 of NiFe2O4–LaFeO3 exhibited a high dielectric constant value of 10390 at a frequency of 1 kHz with a several-fold increase in conductivity. The high conductivity resulted in a high dielectric loss. The origin of such a high dielectric constant and loss have been attributed to the Maxwell-Wagner type space charge polarization arising from the microstructure that consists of large and continuous grain boundaries, and the conducting phase at the interface, respectively.  相似文献   
10.
Hypertension induces renal fibrosis or tubular interstitial fibrosis, which eventually results in end-stage renal disease. Epithelial-to-mesenchymal transition (EMT) is one of the underlying mechanisms of renal fibrosis. Though previous studies showed that Ecklonia cava extracts (ECE) and dieckol (DK) had inhibitory action on angiotensin (Ang) I-converting enzyme, which converts Ang I to Ang II. It is known that Ang II is involved in renal fibrosis; however, it was not evaluated whether ECE or DK attenuated hypertensive nephropathy by decreasing EMT. In this study, the effect of ECE and DK on decreasing Ang II and its down signal pathway of angiotensin type 1 receptor (AT1R)/TGFβ/SMAD, which is related with the EMT and restoring renal function in spontaneously hypertensive rats (SHRs), was investigated. Either ECE or DK significantly decreased the serum level of Ang II in the SHRs. Moreover, the renal expression of AT1R/TGFβ/SMAD was decreased by the administration of either ECE or DK. The mesenchymal cell markers in the kidney of SHRs was significantly decreased by ECE or DK. The fibrotic tissue of the kidney of SHRs was also significantly decreased by ECE or DK. The ratio of urine albumin/creatinine of SHRs was significantly decreased by ECE or DK. Overall, the results of this study indicate that ECE and DK decreased the serum levels of Ang II and expression of AT1R/TGFβ/SMAD, and then decreased the EMT and renal fibrosis in SHRs. Furthermore, the decrease in EMT and renal fibrosis could lead to the restoration of renal function. It seems that ECE or DK could be beneficial for decreasing hypertensive nephropathy by decreasing EMT and renal fibrosis.  相似文献   
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