排序方式: 共有3条查询结果,搜索用时 15 毫秒
1
1.
2.
Hattingen E Lanfermann H Menon S Neumann-Haefelin T de Rochement RD Stamelou M Höglinger GU Magerkurth J Pilatus U 《Magma (New York, N.Y.)》2009,22(1):43-52
OBJECT: To evaluate if combined (1)H and (31)P MR spectroscopic imaging (MRSI) before and after treatment of severe internal carotid artery (ICA) stenosis detects significant changes in energy metabolism in the basal ganglia of both hemispheres. MATERIALS AND METHODS: A group of 14 patients with high-grade ICA stenosis and 11 healthy control subjects were examined with 2D (1)H MRSI and 3D (31)P MRSI at 3 T before and after treatment of severe ICA stenosis. Spectroscopic data were processed with LCModel and jMRUI software. Changes of the phosphorylated metabolites, pH, N-acetyl-acetate, creatine and choline-containing compounds prior/post intervention were analyzed and patients' data were compared with that of control subjects. RESULTS: Untreated patients had significantly higher Adenosindiphosphate (ADP) in basal ganglia ipsi- and contralateral to the side of ACI stenosis compared to controls. After treatment, ADP of both hemispheres significantly decreased by approximately 20% compared to the pre-treatment values. Further, significant decreases of phosphorylated metabolites prior/post intervention were found for patients compared to controls. CONCLUSION: This spectroscopic study reveals that unilateral high-grade ICA stenosis has an effect on cerebral high-energy metabolism of both hemispheres, which is at least partially reversible after treatment. Therefore the restoration of blood flow in high-grade ICA stenosis recovers the impaired energy balance of the brain. 相似文献
3.
The challenges in detection, localization, and staging of prostate cancer have prompted the investigation of the role of various
magnetic resonance (MR) methodologies in a large cohort of men prior to biopsy. The identification of suspicious areas of
malignancy was carried out using magnetic resonance imaging (MRI), magnetic resonance spectroscopic imaging (MRSI) and diffusion-weighted
imaging (DWI). Our data shows that apparent diffusion coefficient (ADC) may be a reliable marker to differentiate normal,
benign, and malignant prostate tissues similar to the metabolite ratio. Also, the combined use of MRSI and DWI improves the
diagnosis of prostate cancer. In this review, we present our experience on the use of MRI, MRSI and DWI methods in the assessment
of prostate cancer in Indian men. Further, analysis of the comparison of the ADC and the metabolite ratio values reported
in the literature across various patient populations are presented.
An erratum to this article can be found at 相似文献
1