复合固体推进剂在石灰石矿山深孔爆破中的应用

通过前期对石灰石矿山露天深孔爆破技术的了解和考察，首次将复合固体推进剂余药应用于石灰石矿山爆破工程，基于原有使用炸药的设计方法，结合现场情况，针对复合固体推进剂设计了一套爆破方案，并不断优化爆破参数，爆破结果表明，复合固体推进剂能够很好的满足石灰石矿山露天深孔爆破的要求，解决了长期以来以焚烧方式进行复合固体推进剂余药的销毁工作，为复合固体推进剂余药的销毁提供了一条新途径。     

复合固体推进剂中固体填料的安息角测试与仿真

复合固体推进剂含有固体颗粒较多，离散单元法是一种适合固体推进剂生产过程数值仿真的有效方法，颗粒物料的接触参数是保证离散单元法仿真精度的关键。本文以复合固体推进剂的主要组分铝粉和高氯酸铵固体颗粒为研究对象，通过实验测试获得了相关物料的安息角，利用专业离散元软件EDEM仿真模拟了安息角测试实验过程，建立了物料安息角与接触参数之间的联系。研究表明，滚动摩擦系数和滑动摩擦系数越大，安息角越大，物料流动性越差。对比仿真与实验结果，通过逆向反推法确定了物料的滑动摩擦系数和滚动摩擦系数两个关键接触参数。铝粉与高氯酸铵1∶2混合颗粒的滑动摩擦系数为0.2，滚动摩擦系数为0.05。为固体推进剂加工生产过程离散元数值仿真提供了关键基础数据。     

Sulfonylguanidine Derivatives as Potential Antimelanoma Agents

Sulfonylguanidines are interesting bioactive compounds with a broad range of applications in the treatment of different pathologies. 2-Aminobenzazole-based structures are well employed in the development of new anticancer drugs. Two series of novel N-benzazol-2-yl-N′-sulfonyl guanidine derivatives were synthesized with the sulfonylguanidine in either an extra- or intracyclic frame. They were evaluated for their antiproliferative activity against malignant melanoma tumor cells, thus allowing structure-activity relationships to be defined. Additionally, NCI-60 screening was performed for the best analogue to study its efficiency against a panel of other cancer cell lines. The stability profile of this promising compound was then validated. During the synthetic process, an unexpected new deamidination of the sulfonylguanidine towards sulfonamide function was also identified.     

基于密闭爆发器试验的发射装药内弹道性能预估

为了预估发射装药的内弹道性能,建立了一种基于密闭爆发器试验检测发射药的静态燃烧性能参数进而预测其装药内弹道性能的方法,采用不同批次的单樟-5/7发射药进行了装药性能预估计算,并基于30 mm火炮对内弹道性能预估精度进行了试验验证。结果表明,采用所建立的基于密闭爆发器试验的发射装药内弹道性能预估方法计算获得的最大膛压为376.0 MPa,与试验测试的膛压平均值388.7 MPa的计算误差为3.27%;计算的炮口初速为1143.5 m/s,与试验测试的炮口初速平均值1156.3 m/s的计算误差为1.11%。所建立的基于密闭爆发器试验的发射装药内弹道性能预估方法具有较高的精度,可对发射药样品不同批次间的内弹道性能进行高效精确的预估,为长期贮存发射药使用寿命的判定及发射药产品的出厂校验提供了一种高效低成本的弹道性能评价方法。     

α–ω Alkenyl-bis-S-Guanidine Thiourea Dihydrobromide Affects HeLa Cell Growth Hampering Tubulin Polymerization

Cancer is going to be the first cause of mortality worldwide in the 21th century. It is considered a multifactorial disease that results from the combined influence of many genetic aberrations, leading to abnormal cell proliferation. As microtubules are strongly implicated in cellular growth, they represent an important target for cancer treatment. The well-known microtubule-targeting agents (MTAs) including paclitaxel, colchicine and vinca alkaloids are commonly used in the treatment of various cancers. However, adverse effects and drug resistance are major limitations in their clinical use. To find new candidates able to induce microtubule alteration with reduced toxic effects or drug resistance, we studied a small new series of derivatives that present imidazolinic, guanidinic, thioureidic and hydrazinic groups ( 1 – 9 ). All the compounds were tested for their antitumor activity against a panel of six tumoral cell models. In particular, compound 8 (nonane-1,9-diyl-bis-S-amidinothiourea dihydrobromide) showed the lowest IC₅₀ value against HeLa cells, together with a low cytotoxicity for normal cells. This compound was able to induce the apoptotic mitochondrial pathway and inhibited tubulin polymerization with a similar efficacy to vinblastine and nocodazole. Taken together, these promising biological properties make compound 8 useful for the development of novel therapeutic approaches in cancer treatment.     

Humidifier disinfectant and use characteristics associated with lung injury in Korea

Since around the year 2000, hundreds of people in Korea have developed humidifier disinfectant‐associated lung injury (HDLI). We collected all HD exposure‐related information from the field investigations into the locations in which the 1199 registered patients had used HD. Among the people who registered, 38% (1st round = 214, 2nd = 73, 3rd = 166) were confirmed as HDLI patients. Children aged under eight years old made up the highest proportion of HDLI cases (N = 279, 62%), followed by pregnant women (N = 31, 7%). One hundred thirty‐three (29%) of the confirmed HDLI patients died. Fifty‐seven percent of HDLI patients (N = 259) developed HDLI after <1 year of HD use. The number of HDLI patients who used only the Oxy Saksak HD brand was found to be 176 (39%), followed by the brands Cefu (N = 27, 6%) and Aekyung (N = 22, 5%). HD products containing only polyhexamethylene guanidine phosphate (PHMG‐P) were the most frequently used among HDLI patients (N = 234, 52%), followed by oligo (2‐(2‐ethoxy)ethoxyethyl) guanidinium (PGH) (N = 27, 6%) and a mixture of chloromethylisothiazolinone (CMIT) and methylisothiazolinone (MIT) (N = 26, 6%). The average PHMG‐P inhalation level estimated from the patient group classified as suffering lung injury definitely associated with HD use was 145.1 μg/m³ (N = 91, SD = 395.1 μg/m³), higher than levels estimated from both the probable and possible HDLI patient groups. In conclusion, HD exposure‐related variables, including type of HD brand and estimated inhalation HD level, were associated with the risk of HDLI.     

A new synthetic metamodel methodology for liquid‐propellant engine's cooling system optimization

The present paper strives for optimization of the cooling system of a liquid‐propellant engine (LPE). To this end, the new synthetic metamodel methodology utilizing the design of experiment method and the response surface method was developed and implemented as two effective means of designing, analyzing, and optimizing. The input variables, constraints, objective functions, and their surfaces were identified. Hence, the design and development strategy of combustion chamber and nozzle was clarified, and 64 different experiments were carried out on the RD‐161 propulsion system, of which 47 experiments were approved and compatible with the problem constraints. This engine used all three modes of cooling: the radiation cooling, the regenerative cooling, and the film cooling. The response surface curves were drawn and the related objective function equations were obtained. The analysis of variance results indicate that the developed synthetic model is capable to predict the responses adequately within the limits of input parameters. The three‐dimensional response surface curves and contour plots have been developed to find out the combined effects of input parameters on responses. In addition, the precision of the models was assessed and the output was interpreted and analyzed, which showed high accuracy. Therefore, the desirability function analysis has been applied to LPE's cooling system for multiobjective optimization to maximize the total heat transfer and minimize the cooling system pressure loss simultaneously. Finally, confirmatory tests have been conducted with the optimum parametric conditions to validate the optimization techniques. In conclusion, this methodology optimizes the LPE's cooling system, a 2% increase in the total heat transfer, and a 38% decrease in the pressure loss of the cooling system. These values are considerably large for the LPE design.     

钝感推进剂配方研究及发展趋势

从钝感黏合剂、钝感增塑剂、钝感高能填料以及新型复合材料等方面综述了国内外钝感固体推进剂配方及钝感方法进展。结果表明,HTPE黏合剂、BDNPF/A增塑剂、FOX-7高能填料以及HMX-TATB核-壳微粒等均可有效降低推进剂感度。今后钝感推进剂的重点研究方向主要为推进剂钝感机理、钝感推进剂能量与感度关系、钝感材料的匹配技术以及影响感度的综合因素等。     

Sphinganine‐Like Biogenesis of (E)‐1‐Nitropentadec‐1‐ene in Termite Soldiers of the Genus Prorhinotermes

In 1974, (E)‐1‐nitropentadec‐1‐ene, a strong lipophilic contact poison of soldiers of the termite genus Prorhinotermes, was the first‐described insect‐produced nitro compound. However, its biosynthesis remained unknown. In the present study, we tested the hypothesis that (E)‐1‐nitropentadec‐1‐ene biosynthesis originates with condensation of amino acids with tetradecanoic acid. By using in vivo experiments with radiolabeled and deuterium‐labeled putative precursors, we show that (E)‐1‐nitropentadec‐1‐ene is synthesized by the soldiers from glycine or L ‐serine and tetradecanoic acid. We propose and discuss three possible biosynthetic pathways.     

氟碳黏合剂研究进展

综述了国内外氟碳黏合剂研究进展,对主要品种的氟碳黏合剂的发展历程、性能、应用以及发展趋势作了简要评述。认为端羟基氟碳缩甲醛聚醚和含氟氧杂丁环聚醚是值得关注的高能量密度推进剂用黏合剂品种,其在特殊性能材料等民品领域也有较广阔的应用。