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K. STANZL L. ZASTROW J. RÖDING C. ARTMANN 《International journal of cosmetic science》1996,18(3):137-150
In a preliminary clinical study, two cosmetic preparations were compared, one without an oxygen carrier and therefore without oxygen, the other one containing the oxygen carrier, fully saturated with oxygen. The parameters measured were the moisture content of the skin and the skin profile. Since the oxygen-free product contained the same ingredients, including phospholipids in liposomal form, with the exception of perfluorodecalin – the oxygen carrier, this investigation showed that perfluorodecalin plus molecular oxygen improves the barrier function of the skin. In a second clinical study, five cosmetic preparations containing various amounts of molecular oxygen from 1.44 ml to 4.5 ml per 100 ml product were compared. The parameters measured were the oxygen partial pressure of the skin, the moisture content of the skin, and the skin profile. A linear dose-dependent increase in oxygen partial pressure of the skin ( r =0.978) and a linear dose-dependent reduction in fine lines and wrinkles ( r =0.9855) was found. The results for the increase in skin moisture were more difficult to interpret. There seemed to be an overlap of the moisturizing base with the efficacy coming from the increasing amount of oxygen per application. 相似文献
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Samir Abouhilale Jacques Greiner Jean G. Riess 《Journal of the American Oil Chemists' Society》1992,69(1):1-8
A new series of perfluoroalkylated fatty acid monoesters of α,α-trehalose and sucrose has been evaluated with respect to their
physicochemical and biological properties for possible biomedical use. These water-soluble compounds strongly reduce the water
surface tension and fluorocarbon/water interfacial tension. As co-surfactants in perfluorodecalin/Pluronic F-68 type emulsions
they significantly increase the stability of these emulsions. Remarkably stable concentrated perfluorodecalin-in-water (50%
w/v) emulsions were obtained when the C8F17CH2CH2C(O)-α,α-trehalose monoester was used as the sole surfactant, while no emulsion could be obtained with its maltoside analogue.
No significant effect on the growth and viability of Namalva cell cultures and no hemolytic activity on human erythrocytes
at concentrations up to 50 g/L were detected for these amphiphiles in spite of their high surface activity. The LD50 was found to be in the range of 250–375 mg/kg of body weighti.v. in mice. 相似文献
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