Lipids and Antiplatelet Therapy: Important Considerations and Future Perspectives

Lipids play an essential role in platelet functions. It is known that polyunsaturated fatty acids play a role in increasing platelet reactivity and that the prothrombotic phenotype plays a crucial role in the occurrence of major adverse cardiovascular events. The ongoing increase in cardiovascular diseases’ incidence emphasizes the importance of research linking lipids and platelet function. In particular, the rebound phenomenon that accompanies discontinuation of clopidogrel in patients receiving dual antiplatelet therapy has been associated with changes in the lipid profile. Our many years of research underline the importance of reduced HDL values for the risk of such a rebound effect and the occurrence of thromboembolic events. Lipids are otherwise a heterogeneous group of molecules, and their signaling molecules are not deposited but formed “on-demand” in the cell. On the other hand, exosomes transmit lipid signals between cells, and the profile of such changes can be monitored by lipidomics. Changes in the lipid profile are organ-specific and may indicate new drug action targets.     

FPGA设计的层次化实验项目的构建

数字电子技术是电子信息类的专业技术基础课程,一方面近些年可编程技术的发展及应用,改变了数字系统的设计理念、设计方法,传统的基于原理图和中小规模集成电路的设计方法已被FPGA所取代,HDL已经成为数字设计技术主流；另一方面在当前“新工科”理念下,要培养具有工程实践能力的人才,但传统工科教育的课程架构却难以满足这一要求。课程内容必须跟上时代发展,要服务社会,那么课程与教学内容的改革是无法回避的,本文以传统数字电子技术为基础,结合实际案例,从点、线、面、体四个层次设计实验项目,让学生快速入手并掌握FPGA的设计。     

近景线阵CCD数据采集系统的设计与实现

针对Kodak的RGB三色线阵CCD-KLI14403设计一款基于CPLD的高分辨率线阵CCD实时数据采集系统.系统利用Verilog HDL进行程序设计实现CPLD对各个功能模块和逻辑单元的时序控制,设计采用线阵CCD作为系统图像传感器,以图像专用A/D处理芯片对CCD的输出信号进行噪声处理和模数转换,最后通过USB2.0接口实现上位机与下位机之间控制指令和采集数据的实时传输.这种设计方法不仅降低了对系统各模块之间的协调控制难度,而且具有驱动时序精确、抗干扰性能良好、输出信号稳定等特点.实验结果表明,该设计系统可以有效地完成图像数据的采集和传输,达到了预期效果,且设计灵活,系统性能较好,具有一定的通用性和科研价值.     

基于FPGA图像处理技术在钢板表面缺陷检测系统中的应用

为了解决钢板表面缺陷视觉检测系统中图像处理的瓶颈问题,采用基于FPGA的嵌入式处理系统完成大数据量、实时、在线的处理任务,从而满足高速、宽幅、高分辨率的检测要求.嵌入式系统以Altera公司最新的Stratix FPGA作为核心处理器,在分析FPGA专有的硬件结构基础上,对图像处理中的模板卷积算法进行了优化设计,采用Verilog语言对算法完成建模与实现,并在Quartus Ⅱ平台进行了仿真验证.实验与算法仿真证明嵌入式处理系统的可行性与工程实用性,从而表面缺陷检测系统中的图像信息实时处理这一关键问题得以解决.     

基于Verilog的异步收发通信的应用

本文介绍了一种在现场可编程门阵列(FPGA)上实现UART的方法,首先阐述了UART异步串行通信原理,然后介绍了实现UART异步串行通信的硬件接口电路及各部分硬件模块,以及用硬件描述语言Verilog进行开发UART通信接口电路的FPGA实现。系统结构进行了模块化分解,使之适应自顶向下(Top-Down)的设计方法。     

Assembly and Characterization of Biocompatible Coenzyme Q10-Enriched Lipid Nanoparticles

Coenzyme Q₁₀ (CoQ₁₀) is a strongly hydrophobic lipid that functions in the electron transport chain and as an antioxidant. CoQ₁₀ was conferred with aqueous solubility by incorporation into nanoparticles containing phosphatidylcholine (PtdCho) and apolipoprotein (apo) A-I. These particles, termed CoQ₁₀ nanodisks (ND), contain 1.0 mg CoQ₁₀/5 mg PtdCho/2 mg apoA-I (97% CoQ₁₀ solubilization efficiency). UV/Vis absorbance spectroscopy of CoQ₁₀ ND revealed a characteristic absorbance peak centered at 275 nm. Incorporation of CoQ₁₀ into ND resulted in quenching of apoA-I tryptophan fluorescence emission. Gel filtration chromatography of CoQ₁₀ ND gave rise to a single major absorbance peak and HPLC of material extracted from this peak confirmed the presence of CoQ₁₀. Incubation of cultured cells with CoQ₁₀ ND, but not empty ND, resulted in a significant increase in the CoQ₁₀ content of mitochondria as well as enhanced oxidative phosphorylation, as observed by a ~24% increase in maximal oxygen consumption rate. Collectively, a facile method to solubilize significant quantities of CoQ₁₀ in lipid nanoparticles has been developed. The availability of CoQ₁₀ ND provides a novel means to investigate biochemical aspects of CoQ₁₀ uptake by cells and/or administer it to subjects deficient in this key lipid as a result of inborn errors of metabolism, statin therapy, or otherwise.     

基于Verilog的下三角矩阵求逆设计与实现

矩阵运算广泛应用于各类电路计算中,矩阵运算的硬件实现能够充分发挥硬件的速度和并行性,其中矩阵求逆是矩阵运算中重要的运算.根据矩阵求逆算法的基本思想,本文提出了一种最大阶数可达16 × 16的矩阵求逆方案,通过硬件描述语言verllog建模,用Design Compile进行综合及进行modelsim仿真,仿真结果表明这...     

SDH中HDB3编解码电路的FPGA实现

SDH传输系统中,为了使传输波形便于提取定时信息和检错,选择HDB3码.通过Verilog HDL编写程序代码,在Quartus Ⅱ 9.0环境下,完成了布局布线和时序仿真,给出了仿真结果,选用ALTERA公司的CycloneⅢ系列FPGA芯片,实验结果与理论输出值一致.     

CCSDS中位平面编码的FPGA优化实现

CCSDS图像压缩算法是空间数据系统咨询委员会针对深空探测图像制定的图像压缩标准.该算法的码率可控、复杂度较低,而且算法结构适合于硬件实现,支持对空间数据的高速实时处理.给出了基于可编程逻辑电路硬件的位平面编码算法的设计与实现方法,并通过分析直流、交流系数编码过程中各模块内部和模块间的关系,设计了流水线,使系统处理速度...