Mechanisms of Reciprocal Regulation of Gonadotropin-Releasing Hormone (GnRH)-Producing and Immune Systems: The Role of GnRH,Cytokines and Their Receptors in Early Ontogenesis in Normal and Pathological Conditions

Different aspects of the reciprocal regulatory influence on the development of gonadotropin-releasing hormone (GnRH)-producing- and immune systems in the perinatal ontogenesis and their functioning in adults in normal and pathological conditions are discussed. The influence of GnRH on the development of the immune system, on the one hand, and the influence of proinflammatory cytokines on the development of the hypothalamic-pituitary-gonadal system, on the other hand, and their functioning in adult offspring are analyzed. We have focused on the effects of GnRH on the formation and functional activity of the thymus, as the central organ of the immune system, in the perinatal period. The main mechanisms of reciprocal regulation of these systems are discussed. The reproductive health of an individual is programmed by the establishment and development of physiological systems during critical periods. Regulatory epigenetic mechanisms of development are not strictly genetically controlled. These processes are characterized by a high sensitivity to various regulatory factors, which provides possible corrections for disorders.     

Influence of accelerated curing on the compressive strength of polymer-modified concrete

In recent building practice, rapid construction is one of the principal requisites. Furthermore, in designing concrete structures, compressive strength is the most significant of all parameters. While 3-d and 7-d compressive strength reflects the strengths at early phases, the ultimate strength is paramount. An effort has been made in this study to develop mathematical models for predicting compressive strength of concrete incorporating ethylene vinyl acetate (EVA) at the later phases. Kolmogorov-Smirnov (KS) goodness-of-fit test was used to examine distribution of the data. The compressive strength of EVA-modified concrete was studied by incorporating various concentrations of EVA as an admixture and by testing at ages of 28, 56, 90, 120, 210, and 365 d. An accelerated compressive strength at 3.5 hours was considered as a reference strength on the basis of which all the specified strengths were predicted by means of linear regression fit. Based on the results of KS goodness-of-fit test, it was concluded that KS test statistics value (D) in each case was lower than the critical value 0.521 for a significance level of 0.05, which demonstrated that the data was normally distributed. Based on the results of compressive strength test, it was concluded that the strength of EVA-modified specimens increased at all ages and the optimum dosage of EVA was achieved at 16% concentration. Furthermore, it was concluded that predicted compressive strength values lies within a 6% difference from the actual strength values for all the mixes, which indicates the practicability of the regression equations. This research work may help in understanding the role of EVA as a viable material in polymer-based cement composites.     

Moderate lameness leads to marked behavioral changes in dairy cows

Lameness is one of the most prevalent diseases affecting the welfare of cows in modern dairy production. Lameness leads to behavioral changes in severely lame cows, which have been investigated in much detail. For early detection of lameness, knowledge of the effects of moderate lameness on cow behavior is crucial. Therefore, the behavior of nonlame and moderately lame cows was compared on 17 Swiss dairy farms. On each farm, 5 to 11 nonlame (locomotion score 1 of 5) and 2 to 7 moderately lame (locomotion score 3 of 5) cows were selected for data collection in two 48-h periods (A, B) separated by an interval of 6 to 10 wk. Based on visual locomotion scoring, 142 nonlame and 66 moderately lame cows were examined in period A and 128 nonlame and 53 moderately lame cows in period B. Between these 2 periods, the cows underwent corrective hoof trimming. Lying behavior, locomotor activity, and neck activity were recorded by accelerometers (MSR145 data logger, MSR Electronics GmbH, Seuzach, Switzerland), and feeding and rumination behaviors by noseband sensors (RumiWatch halter, ITIN + HOCH GmbH, Liestal, Switzerland). Furthermore, visits to the brush and the concentrate feeder, and the milking order position were recorded. In comparison with nonlame cows, moderately lame cows had a longer lying duration, a longer average lying bout duration, and a greater lateral asymmetry in lying duration. Average locomotor activity, locomotor activity during 1 h after feed delivery or push-ups, and average neck activity were lower in moderately lame cows. Eating time and the number of eating chews (jaw movements) were reduced in moderately lame compared with nonlame cows, whereas no effect of moderate lameness was evident for ruminating time, number of ruminating chews and boluses, and average number of ruminating chews per bolus. Moderately lame cows visited the concentrate feeder and the brush less frequently, and they were further back in the milking order compared with nonlame cows. In conclusion, nonlame and moderately lame cows differed in a biologically relevant way in many of the behavioral variables investigated in this study. Therefore, the use of these behavioral changes seems to be promising to develop a tool for early lameness detection.     

A volume element model (VEM) for energy systems engineering

This work presents a simplified modeling and simulation approach for energy systems engineering that is capable of providing quick and accurate responses during system design. For that, the laws of conservation are combined with available empirical and theoretical correlations to quantify the diverse types of flows that cross the system and produce a simplified tridimensional mathematical model, namely a volume element model (VEM). The physical domain of interest is discretized in space, thus producing a system of algebraic and ODEs with respect to time, whose solution delivers the project variables spatial distribution and dynamic response. In order to illustrate the application of the VEM in energy systems engineering, three example problems are considered: (i) a regenerative heat exchanger; (ii) a power electronic building block (PEBB); and (iii) a notional all‐electric ship. The same mathematical model was used to analyze problems (ii) and (iii), that is, the thermal management of heat‐generating equipment packaging. In the examples, the converged mesh had a total of 20, 2000, and 7725 volume elements. The third problem led to the largest simulation, which for steady‐state cases took between 5 and 10 min of computational time to reach convergence and for the ship dynamic response 50 min (i.e., 80,000 s of real time). The regenerative heat exchanger model demonstrated how VEM allowed for the coexistence of different phases (subsystems) within the same volume element. The thermal management model was adjusted and experimentally validated for the PEBB system, and it was possible to perform a parametric and dynamic analysis of the PEBB and of the notional all‐electric ship. Therefore, because of the observed combination of accuracy and low computational time, it is expected that the model could be used as an efficient tool for design, control, and optimization in energy systems engineering. Copyright © 2014 John Wiley & Sons, Ltd.     

基于瓦斯涌出特征的钱家营矿掘进工作面突出预警系统应用

为实现钱家营矿掘进工作面煤与瓦斯突出实时预警,提出一种基于瓦斯涌出特征的预警方法。依据巷道高低浓度甲烷传感器实时监测数据,通过离散回归理论分析煤与瓦斯突出前的瓦斯涌出量,建立预警指标特征序列,确定掘进工作面煤与瓦斯突出预警指标危险临界值:方差0.018,波峰差0.41,波动斜率±0.027。在此基础上构建了非接触式煤与瓦斯突出可视化预警系统并在钱家营矿进行现场应用。结果表明,以瓦斯涌出特征值作为预警指标,能够准确监测到井下瓦斯异常现象,达到瓦斯数据实时解算和可视化预警的目的,为钱家营矿掘进工作面防突工作提供技术借鉴。     

Turning tradition into an instrument of research: The editorship of William Nicholson (1753–1815)

Mainly known for its links to the periodical market and radical politics, this article recontextualizes the editorship of William Nicholson (1753–1815) in terms of its roots in the metropolitan natural philosophical circles of the second half of the 18th century as well as its impact on experimenters and men of science after 1797. The article argues that Nicholson's editorship of the Journal of Natural Philosophy, Chemistry, and the Arts was a means to expand his philosophical significance among natural philosophers at home and abroad—and was, in fact, a form of epistemological subversion that challenged the “Banksian Learned Empire.”     

综掘设备人员识别预警系统

为解决煤矿井下综合掘进设备由于视野盲区造成的后部输送机摆动误伤行人的安全问题,以红外成像和图像处理技术为基础,设计出一种适用于井下综掘设备的人员识别预警系统。系统采用模块化设计和集成封装,在连续采煤机上进行应用测试并进行结构优化,测试证明系统识别精度高,响应迅速,能够准确识别综掘设备危险区域内的行人,并实现危险区域外2 m范围内的人员预警及1 m范围1 s内的中断停机操作。     

核算前移在冶炼企业优化成本控制中的应用

针对国际黄金价格的走低,黄金冶炼企业如何在激烈的市场竞争中寻求更大的利润空间,优化成本控制显得尤为重要。以某冶炼厂为例,阐述核算前移在优化企业成本控制中的应用,以达到降本增效的目的,实现企业利润的最大化。     

新中国早期产品品牌命名和设计范式探究——以烟标为例

新中国早期产品品牌的命名和设计,在政治内容、审美趣味与商业企图之间获得了平衡。构建了易于被大众接受,群众喜闻乐见,紧随时代潮流的命名和设计范式。其中,以烟标最为典型,散发出鲜明的视觉特色和独有魅力,给人们留下诸多的回忆。为新中国立国建国、经济建设、航天国防、友好和平和文化生活等方面信息的传播和价值观的塑造,作出了不可忽视的贡献,也为现代产品品牌的命名和设计提供了早期的范式参考。