首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   81665篇
  免费   9448篇
  国内免费   3993篇
电工技术   7436篇
技术理论   5篇
综合类   6159篇
化学工业   11574篇
金属工艺   3242篇
机械仪表   3845篇
建筑科学   7517篇
矿业工程   2401篇
能源动力   2162篇
轻工业   7703篇
水利工程   2238篇
石油天然气   2375篇
武器工业   744篇
无线电   9779篇
一般工业技术   9297篇
冶金工业   4012篇
原子能技术   1035篇
自动化技术   13582篇
  2024年   110篇
  2023年   1703篇
  2022年   3214篇
  2021年   4389篇
  2020年   3353篇
  2019年   3056篇
  2018年   2972篇
  2017年   2936篇
  2016年   3809篇
  2015年   4327篇
  2014年   5834篇
  2013年   5765篇
  2012年   5578篇
  2011年   5151篇
  2010年   3890篇
  2009年   3986篇
  2008年   3935篇
  2007年   5334篇
  2006年   5116篇
  2005年   4412篇
  2004年   3116篇
  2003年   2822篇
  2002年   2050篇
  2001年   1433篇
  2000年   1029篇
  1999年   913篇
  1998年   610篇
  1997年   521篇
  1996年   511篇
  1995年   441篇
  1994年   380篇
  1993年   277篇
  1992年   258篇
  1991年   212篇
  1990年   231篇
  1989年   199篇
  1988年   154篇
  1987年   91篇
  1986年   74篇
  1985年   94篇
  1984年   99篇
  1983年   67篇
  1982年   61篇
  1981年   47篇
  1980年   60篇
  1979年   42篇
  1966年   31篇
  1964年   40篇
  1962年   67篇
  1955年   29篇
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Deposition of amyloid β (Aβ) fibrils in the brain is a key pathologic hallmark of Alzheimer’s disease. A class of polyphenolic biflavonoids is known to have anti-amyloidogenic effects by inhibiting aggregation of Aβ and promoting disaggregation of Aβ fibrils. In the present study, we further sought to investigate the structural basis of the Aβ disaggregating activity of biflavonoids and their interactions at the atomic level. A thioflavin T (ThT) fluorescence assay revealed that amentoflavone-type biflavonoids promote disaggregation of Aβ fibrils with varying potency due to specific structural differences. The computational analysis herein provides the first atomistic details for the mechanism of Aβ disaggregation by biflavonoids. Molecular docking analysis showed that biflavonoids preferentially bind to the aromatic-rich, partially ordered N-termini of Aβ fibril via the π–π interactions. Moreover, docking scores correlate well with the ThT EC50 values. Molecular dynamic simulations revealed that biflavonoids decrease the content of β-sheet in Aβ fibril in a structure-dependent manner. Hydrogen bond analysis further supported that the substitution of hydroxyl groups capable of hydrogen bond formation at two positions on the biflavonoid scaffold leads to significantly disaggregation of Aβ fibrils. Taken together, our data indicate that biflavonoids promote disaggregation of Aβ fibrils due to their ability to disrupt the fibril structure, suggesting biflavonoids as a lead class of compounds to develop a therapeutic agent for Alzheimer’s disease.  相似文献   
2.
3.
针对直流配电网母线电压稳定性问题,设计了一种变增益线性扩张状态观测器(variable gain linear extended state observer,VGLESO),有效地解决了传统高增益线性扩张状态观测器(linear extended state observer extended state observer,LESO)在运行初始阶段输出存在峰值的问题。在此基础上进一步提出了一种变增益滑模自抗扰控制策略,将其应用到直流配电网AC-DC双向变流器控制系统中的电压外环。变增益滑模自抗扰控制策略在不需要增加额外电流传感器的情况下,就能够实现对系统总扰动的快速跟踪和补偿,有效地抑制了母线电压波动,提高了系统的动态响应。从理论上证明了VGLESO和变增益滑模自抗扰控制策略的稳定性。最后通过MATLAB/Simulink验证了该控制策略的可行性与正确性。  相似文献   
4.
The Gli-B1-encoded γ-gliadins and non-coding γ-gliadin DNA sequences for 15 different alleles of common wheat have been compared using seven tests: electrophoretic mobility (EM) and molecular weight (MW) of the encoded major γ-gliadin, restriction fragment length polymorphism patterns (RFLPs) (three different markers), Gli-B1-γ-gliadin-pseudogene known SNP markers (Single nucleotide polymorphisms) and sequencing the pseudogene GAG56B. It was discovered that encoded γ-gliadins, with contrasting EM, had similar MWs. However, seven allelic variants (designated from I to VII) differed among them in the other six tests: I (alleles Gli-B1i, k, m, o), II (Gli-B1n, q, s), III (Gli-B1b), IV (Gli-B1e, f, g), V (Gli-B1h), VI (Gli-B1d) and VII (Gli-B1a). Allele Gli-B1c (variant VIII) was identical to the alleles from group IV in four of the tests. Some tests might show a fine difference between alleles belonging to the same variant. Our results attest in favor of the independent origin of at least seven variants at the Gli-B1 locus that might originate from deeply diverged genotypes of the donor(s) of the B genome in hexaploid wheat and therefore might be called “heteroallelic”. The donor’s particularities at the Gli-B1 locus might be conserved since that time and decisively contribute to the current high genetic diversity of common wheat.  相似文献   
5.
In this study, we investigate the immunomodulatory effects of a novel antimicrobial peptide, YD1, isolated from Kimchi, in both in vitro and in vivo models. We establish that YD1 exerts its anti-inflammatory effects via up-regulation of the Nrf2 pathway, resulting in the production of HO-1, which suppresses activation of the NF-κB pathway, including the subsequent proinflammatory cytokines IL-1β, IL-6, and TNF-α. We also found that YD1 robustly suppresses nitric oxide (NO) and prostaglandin E2 (PGE2) production by down-regulating the expression of the upstream genes, iNOS and COX-2, acting as a strong antioxidant. Collectively, YD1 exhibits vigorous anti-inflammatory and antioxidant activity, presenting it as an interesting potential therapeutic agent.  相似文献   
6.
Owing to the prohibition of cosmetic animal testing, various attempts have recently been made using skin-on-a-chip (SOC) technology as a replacement for animal testing. Previously, we reported the development of a pumpless SOC capable of drug testing with a simple drive using the principle that the medium flows along the channel by gravity when the chip is tilted using a microfluidic channel. In this study, using pumpless SOC, instead of drug testing at the single-cell level, we evaluated the efficacy of α-lipoic acid (ALA), which is known as an anti-aging substance in skin equivalents, for skin tissue and epidermal structure formation. The expression of proteins and changes in genotyping were compared and evaluated. Hematoxylin and eosin staining for histological analysis showed a difference in the activity of fibroblasts in the dermis layer with respect to the presence or absence of ALA. We observed that the epidermis layer became increasingly prominent as the culture period was extended by treatment with 10 μM ALA. The expression of epidermal structural proteins of filaggrin, involucrin, keratin 10, and collagen IV increased because of the effect of ALA. Changes in the epidermis layer were noticeable after the ALA treatment. As a result of aging, damage to the skin-barrier function and structural integrity is reduced, indicating that ALA has an anti-aging effect. We performed a gene analysis of filaggrin, involucrin, keratin 10, integrin, and collagen I genes in ALA-treated human skin equivalents, which indicated an increase in filaggrin gene expression after ALA treatment. These results indicate that pumpless SOC can be used as an in vitro skin model similar to human skin, protein and gene expression can be analyzed, and it can be used for functional drug tests of cosmetic materials in the future. This technology is expected to contribute to the development of skin disease models.  相似文献   
7.
为了获取TC11钛合金拉伸性能随应变率的变化规律,对该材料开展了宽应变率范围下的单轴拉伸试验。结果表明,随着应变率从准静态增加到动态,TC11钛合金的屈服强度略有上升,而应变硬化模量下降。此外,在准静态和动态拉伸下,TC11钛合金均发生了剪切断裂,但动态断裂面上韧窝尺寸小于准静态断面上韧窝尺寸。进一步对材料在变形过程中的温升进行了分析,结果发现,高应变率下材料断裂面上更小尺寸的韧窝和材料更容易发生应变软化归因于动态加载情况下材料中产生了更高的温升。  相似文献   
8.
张弛  李浩  胡海涛  朱翀  张玉莹  南国鹏  舒悦 《化工学报》2021,72(Z1):430-436
针对飞行器轴承信号单一且噪声多、需要针对性特征以及需要高可解释性的问题,开发了涵盖具有自适应噪声的完全集合经验模态分解(CEEMDAN)、自动特征工程以及随机森林的故障诊断模型,模型核心为自动进行特征生成以及提取的特征工程。通过该特征工程能够根据不同对象的信号差异,自动提取出不同对象的有效特征,具备对象间的通用性,且该特征工程可根据样本量的不同调整有效特征的数量,丰富特征空间,具备灵活的可扩展性。验证表明,该涵盖自动特征工程的模型的故障分类准确率为95.32%,可较好地在大样本量下区分压缩机轴承上的不同故障。  相似文献   
9.
稳定井壁封堵材料种类众多,对其进行合理分类能为材料优选和稳定井壁效果评价提供依据。目前稳定井壁封堵材料主要以材料外观、力学性能、作用机制以及作用目的等进行分类,各种分类方法之间存在不同程度的交叉,导致同类材料封堵性能评价方法不同,不同类材料的封堵试验效果对比缺乏依据。为了确立同类材料的表征方法,建立不同类材料稳定井壁封堵效果的评价方法,提出以稳定井壁过程中封堵材料分子之间是否发生化学反应为依据,将材料分为物理封堵材料和化学封堵材料两大类。同时,按照封堵带作用形式将物理封堵材料细分为机械支护、桥接封堵、变形充填、泡沫堆积和成膜封堵等5小类;按照发生化学反应类型将化学封堵材料细分为交联封堵材料、胶凝封堵材料和沉淀封堵材料等3小类。该分类方法在一定程度上解决了因材料分类交叉所带来的封堵材料评价方法缺失和试验效果依据缺乏的难题,有利于在封堵作用机理基础上建立评价方法和标准,推动封堵学学科的发展。  相似文献   
10.
刘璐  庞杰 《粮油食品科技》2021,29(2):129-134
凝胶是一种性质介于固体和液体之间的特殊分散体系,魔芋葡甘聚糖(KGM)凝胶稳定性差、强度低,物理共混能方便、快捷地改善其凝胶性质。主要综述KGM复合凝胶的网络结构变化,并介绍不同复合凝胶在食品、医药、材料工程等领域的应用。分析表明,KGM复合凝胶网络能通过氢键、席夫碱反应、形成多重网络结构和填充的方式改善其凝胶特性。  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号