首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   12460篇
  免费   1779篇
  国内免费   1336篇
电工技术   494篇
技术理论   1篇
综合类   827篇
化学工业   1993篇
金属工艺   254篇
机械仪表   782篇
建筑科学   344篇
矿业工程   242篇
能源动力   191篇
轻工业   1682篇
水利工程   34篇
石油天然气   227篇
武器工业   322篇
无线电   4902篇
一般工业技术   1466篇
冶金工业   399篇
原子能技术   107篇
自动化技术   1308篇
  2024年   15篇
  2023年   217篇
  2022年   341篇
  2021年   502篇
  2020年   520篇
  2019年   416篇
  2018年   450篇
  2017年   508篇
  2016年   533篇
  2015年   623篇
  2014年   869篇
  2013年   841篇
  2012年   1116篇
  2011年   1094篇
  2010年   716篇
  2009年   720篇
  2008年   757篇
  2007年   892篇
  2006年   805篇
  2005年   567篇
  2004年   490篇
  2003年   451篇
  2002年   347篇
  2001年   330篇
  2000年   254篇
  1999年   209篇
  1998年   150篇
  1997年   120篇
  1996年   113篇
  1995年   93篇
  1994年   107篇
  1993年   79篇
  1992年   70篇
  1991年   71篇
  1990年   46篇
  1989年   28篇
  1988年   6篇
  1987年   21篇
  1986年   16篇
  1985年   5篇
  1984年   14篇
  1983年   9篇
  1982年   12篇
  1981年   9篇
  1980年   4篇
  1979年   3篇
  1976年   3篇
  1975年   5篇
  1957年   1篇
  1955年   2篇
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Cell encapsulation within hydrogel droplets is transforming what is feasible in multiple fields of biomedical science such as tissue engineering and regenerative medicine, in vitro modeling, and cell-based therapies. Recent advances have allowed researchers to miniaturize material encapsulation complexes down to single-cell scales, where each complex, termed a single-cell microgel, contains only one cell surrounded by a hydrogel matrix while remaining <100 μm in size. With this achievement, studies requiring single-cell resolution are now possible, similar to those done using liquid droplet encapsulation. Of particular note, applications involving long-term in vitro cultures, modular bioinks, high-throughput screenings, and formation of 3D cellular microenvironments can be tuned independently to suit the needs of individual cells and experimental goals. In this progress report, an overview of established materials and techniques used to fabricate single-cell microgels, as well as insight into potential alternatives is provided. This focused review is concluded by discussing applications that have already benefited from single-cell microgel technologies, as well as prospective applications on the cusp of achieving important new capabilities.  相似文献   
2.
为了提升煤矿车辆异常行为检测水平,设计了基于红外遥感信息的煤矿车辆异常行为检测方法。该方法引入清晰度权重以及拉伸系数实现红外遥感图像中目标煤矿车辆部位的局部增强,利用均值漂移算法跟踪增强后的红外遥感图像中目标煤矿车辆,依据煤矿车辆跟踪结果提取煤矿车辆运动方向、运动速度以及运动方向3项异常行为检测参数,采用加权融合方法处理煤矿车辆异常行为检测参数的状态函数,融合结果高于所设定阈值时,煤矿车辆存在异常行为,否则煤矿车辆为正常行驶状态。实验结果表明,该方法可利用煤矿车辆位置、车辆行驶速度以及车辆方向变化检测煤矿车辆异常行为,具有较高的应用性。  相似文献   
3.
目的:通过对药食同源材料组合(藤茶30%、桑叶15%、菊花15%、芦根10%、麦芽10%、甘草10%和淡竹叶10%)中二氢杨梅素进行提取工艺优化,为药食同源材料开发及浸膏粉的生产提供参考。方法:先对提取次数进行考察,再以浸泡时间、加水量和提取时间为影响因素,在单因素试验的基础上,采用L9(34)正交表进行正交试验,优化水提法提取药食同源材料组合中二氢杨梅素的条件。结果:加水量对药食同源材料组合中二氢杨梅素提取量和浸膏得率具有显著影响(P<0.05),综合考虑生产的成本、时效性与稳定性,水提工艺的最优条件为加水浸泡0.5 h,提取2次,第1次加水体积为其质量的10倍提取1.5 h,第2次加水体积为其质量的8倍提取1.0 h。在最佳条件下,65 g药食同源材料组合中二氢杨梅素提取量为3 761.14 mg,浸膏得率为31.42%。结论:热水回流提取法可作为药食同源材料组合的提取方法,此法简单可行,效率高,结果准确,可用于药食同源材料组合中二氢杨梅素的提取工艺优化研究。  相似文献   
4.
Negatively charged fluorescent carbon dots (CDs, Em=608 nm) were hydrothermally prepared from thiophene phenylpropionic acid polymers and then successfully loaded with the positively charged anticancer cargo coptisine, which suffers from poor bioavailability. The formed CD-coptisine complexes were thoroughly characterized by particle size, morphology, drug loading efficiency, drug release, cellular uptake and cellular toxicity in vitro and antitumor activities in vivo. In this nano-carrier system, red emissive CDs possess multiple advantages as follows: 1) high drug loading efficiency (>96 %); 2) sustained drug release; 3) enhanced drug efficacy towards cancer cells; 4) EPR effect; 5) drug release tracing with near-infrared imaging. These properties indicated that red emissive CDs prepared from polymers could be used as a novel drug delivery system with integrated therapeutic and imaging functions in cancer therapy, which are expected to have great potential in future clinical applications.  相似文献   
5.
In the current study, the development of the silicate structure of synthetic calcium silicate hydrates with different calcium contents was followed by in-situ infrared (IR) spectroscopy and correlated to the in-situ phase development evaluated by X-ray diffraction (XRD). A baseline correction method initially developed for X-ray diffractograms was successfully adapted for the complex background of the fingerprint region in in-situ IR, which significantly contributed to signal quality and reproducibility. The development of separate silicate infrared bands could be monitored over 24 h of reaction. These bands could be assigned to oligomeric and dimeric species based on their time and stoichiometry-dependent development. It was clearly shown that the main peak of the dimeric silicate species was overlooked in the literature. The correlation of time-dependent events to in-situ XRD revealed that changes in the unit cell of calcium silicate hydrate are related to silicate polymerization. The results were compared to 29Si-MAS-NMR, which highlighted the benefits of in-situ IR spectroscopy.  相似文献   
6.
High-density La0.9-xSrxK0.1MnO3 ceramics (LSKMO, A-site = La, Sr and K, 0 ≤ x ≤ 0.25) are successfully fabricated by using facile sol-gel method. Electrical properties are performed by using combination of phenomenological percolation (PP) model, double exchange (DE) mechanism, and Jahn-Teller (JT) effect. Moreover, X-ray diffraction and scanning electron microscopy are employed to analyze the structure and morphology of LSKMO ceramics. Valence states and ionic stoichiometry are assessed by using X-ray photoemission spectrometry. Results reveal that Sr2+ ions, substituting La3+ ions, significantly influenced DE mechanism and JT effect. In addition, Sr-doping plays essential role in improving electrical properties of LSKMO ceramics. At optimal doping content of x = 0.09, peak temperature coefficient of resistance (TCR) of the resistivity is found to be 11.56% K?1 at 297.15 K, which is optimal TCR for A-site K-occupied perovskite manganese oxides. These results confirm that polycrystalline LSKMO ceramics render high room-temperature TCR values due to Sr-doping.  相似文献   
7.
Chronic inflammation represents a long-term reaction of the body's immune system to noxious stimuli. Such a sustained inflammatory response sometimes results in lasting damage to healthy tissues and organs. In fact, chronic inflammation is implicated in the development and progression of various diseases, including cardiovascular diseases, respiratory diseases, metabolic diseases, neurodegenerative diseases, and even cancers. Targeting nonresolving inflammation thus provides new opportunities for treating relevant diseases. In this review, we will go over several chronic inflammation-associated diseases first with emphasis on the role of inflammation in their pathogenesis. Then, we will summarize a number of natural products that exhibit therapeutic effects against those diseases by acting on different markers in the inflammatory response. We envision that natural products will remain a rich resource for the discovery of new drugs treating diseases associated with chronic inflammation.  相似文献   
8.
蒸发是大气–土体相互作用的主要方式之一,也是改变土体水分场及影响土体工程性质的重要因素。提出采用红外热成像技术对土体水分的蒸发过程进行试验研究,共配置了3组不同厚度和初始含水率的土样,将其置于恒定温湿度条件下干燥,定时称取试样质量变化获得土样的水分蒸发过程,并利用红外热成像仪实时记录土样表面的温度场变化。结果表明:土样的蒸发速率随干燥时间可分为3个典型阶段,即常速率阶段、减速率阶段和残余阶段。作为响应,土表温度变化也呈现3个典型阶段,即恒定低温阶段、升温阶段和稳定阶段,且与蒸发阶段一一对应。基于蒸发过程中大气–土体之间的物质能量交换特征,通过理论推导,建立了土体蒸发速率与大气–土表温度差之间的线性理论关系,并进行了试验验证,发现该理论关系不受土样初始厚度和含水率的影响。研究成果表明,利用红外热成像技术开展土体蒸发特性研究是可行的,为快速掌握气候作用下土体水分蒸发过程及表面水分场的时空演化特征提供了新的技术思路。  相似文献   
9.
Precision oncology is an emerging approach in cancer care. It aims at selecting the optimal therapy for the right patient by considering each patient’s unique disease and individual health status. In the last years, it has become evident that breast cancer is an extremely heterogeneous disease, and therefore, patients need to be appropriately stratified to maximize survival and quality of life. Gene-expression tools have already positively assisted clinical decision making by estimating the risk of recurrence and the potential benefit from adjuvant chemotherapy. However, these approaches need refinement to further reduce the proportion of patients potentially exposed to unnecessary chemotherapy. Nuclear magnetic resonance (NMR) metabolomics has demonstrated to be an optimal approach for cancer research and has provided significant results in BC, in particular for prognostic and stratification purposes. In this review, we give an update on the status of NMR-based metabolomic studies for the biochemical characterization and stratification of breast cancer patients using different biospecimens (breast tissue, blood serum/plasma, and urine).  相似文献   
10.
提出了一种基于红外检测的变电站设备热状态诊断方案。首先基于变电站设备的红外图像,采用局部方差映射函数和遗传算法阈值提取了变电站设备的热状态数据,以用于对异常区域进行分割。然后构建了红外图像灰度数与变电站设备温度两者之间的关系。最后采用改进的相对温差法达到了对设备热状态进行分类和诊断的目标,并捕获定位了变电站设备的热状态异常区域。实验结果表明,该方法提高了异常热区提取的精度和效率,提升了变电站设备热状态诊断的容错能力,进一步保证了变电站和整个电力系统的运行稳定性。  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号