Crosstalk between MicroRNA and Oxidative Stress in Primary Open-Angle Glaucoma

Reactive oxygen species (ROS) plays a key role in the pathogenesis of primary open-angle glaucoma (POAG), a chronic neurodegenerative disease that damages the trabecular meshwork (TM) cells, inducing apoptosis of the retinal ganglion cells (RGC), deteriorating the optic nerve head, and leading to blindness. Aqueous humor (AH) outflow resistance and intraocular pressure (IOP) elevation contribute to disease progression. Nevertheless, despite the existence of pharmacological and surgical treatments, there is room for the development of additional treatment approaches. The following review is aimed at investigating the role of different microRNAs (miRNAs) in the expression of genes and proteins involved in the regulation of inflammatory and degenerative processes, focusing on the delicate balance of synthesis and deposition of extracellular matrix (ECM) regulated by chronic oxidative stress in POAG related tissues. The neutralizing activity of a couple of miRNAs was described, suggesting effective downregulation of pro-inflammatory and pro-fibrotic signaling pathways, including nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB), transforming growth factor-beta 2 (TGF-β2), Wnt/β-Catenin, and PI3K/AKT. In addition, with regards to the elevated IOP in many POAG patients due to increased outflow resistance, Collagen type I degradation was stimulated by some miRNAs and prevented ECM deposition in TM cells. Mitochondrial dysfunction as a consequence of oxidative stress was suppressed following exposure to different miRNAs. In contrast, increased oxidative damage by inhibiting the mTOR signaling pathway was described as part of the action of selected miRNAs. Summarizing, specific miRNAs may be promising therapeutic targets for lowering or preventing oxidative stress injury in POAG patients.     

基于LabVIEW的激光加工路径识别算法

激光加工应用于各行各业,其作用不可忽视,而且功能越来越丰富.传统的激光加工往往是由上位机生成矢量图导入下位机后控制激光头移动.这种方式局限性在于不能自由的对加工平面上规划好的路径进行加工.为了解决这个问题提出了基于LabVIEW机器视觉的路径识别算法,通过不断改变ROI即感兴趣区域来获取所需的点,将这些点连起来便是所要加工的路径,并将这些点转换成世界坐标传输到控制器来控制激光头的运动,在不断改变ROI的同时必须严格保证ROI不偏离规定路径也不能同时包含其他路径而造成干扰,实验结果显示路径可以被有效识别验证了该算法的可行性.     

趣味设计互动性在厨具产品中的应用探讨

分析了趣味设计中互动性在家居厨具产品形态、色彩、材质、功能等因素中的应用,探究出现代人更希望在厨房环境中能使用到亲切、美观、能带来欣喜情感的有趣厨具,这些期望正是趣味设计的互动性体现,并提出了趣味设计的互动性语言是缩短人与厨具产品距离的途径,它能更多的考虑人的心理需求,能让使用者产生愉快情感的设计。     

一种改进的SUSAN兴趣点检测算法

兴趣点是图像中重要的几何特征,兴趣点的准确检测对于图像处理具有重要意义。为了优化SUSAN算法,提高算法的有效性,对SUSAN兴趣点检测算法中阈值的确定提出了改进。在图像每个像素的SUSAN模板中首先计算阈值t的初值,在利用迭代法获得终值,使其在各种不同的对比度下仍能正确检测兴趣点。实验结果证明了该方法的有效性。     

提高化工工艺学教学质量的几点探索

针对化工工艺学教学中存在的普性问题,从课程本身的内容和特性出发,采用归纳性、创新性、理论性、前沿性教学方法,增加教学的知识性、趣味性、连贯性,提高学生的使命感和认知感,增进了教学效果,提高了教学质量.     

从定向期待到创新期待的升华——浅论《围城》幽默翻译的接受美学

作为中国现代文学史上一道别致的风景,《围城》以其独特的幽默讽刺风格赢得了广大读者的赞誉。结合姚斯提出的"期待视野"概念阐述接受美学对《围城》中幽默翻译的诠释力,并指出在幽默翻译中,应该以译文读者的可接受性为原则来选择不同的翻译方法,最终实现期待视野的融合、幽默效果的传递。     

Can people really “laugh at themselves?”—Experimental and correlational evidence.

Laughing at oneself is considered a core component of the sense of humor in the theories of several authors. In McGhee's (1996) eight-step-training program of the sense of humor, laughing at oneself constitutes one of the most difficult levels. However, until now, only little empirical evidence on laughing at oneself exists. Using a multimethod approach, in the current study, 70 psychology students and a total of 126 peers filled in the Sense of Humor Scale (SHS, McGhee, 1996), containing as a subscale “Laughing at oneself”. In addition, the participants answered the Trait and State forms of the State-Trait-Cheerfulness-Inventory (STCI, Ruch, K?hler, & van Thriel, 1996; Ruch, K?hler, & van Thriel, 1997). They then were confronted with six distorted images of themselves. Facial responses of the participants were videotaped and analyzed using the Facial Action Coding System (FACS, Ekman, Friesen, & Hager, 2002). Four indicators of exhilaration were examined: (a) experienced funniness, (b) AU12 smiles, (c) Duchenne displays, and (d) laughter. Furthermore, fake and masking smiles were studied. Results demonstrated that self- and peer reports of “laughing at oneself” converged moderately. All four indicators of exhilaration were shown, but funniness and laughter seemed to be the most strongly related indicators. Trait cheerfulness and (low) seriousness, and a cheerful mood state formed further characteristics of persons who laugh at themselves. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

论趣味空间的感官体验

以空间的趣味性为中心,分别将空间划为能够带给人愉悦与欢乐的空间、促进友情与交流的空间以及富含文化气息与个性化的空间,通过对不同人的感官体验,阐明了控制空间趣味性的相关因素,为今后的建筑空间设计提供依据。     

包装的趣味化设计

趣味化的包装设计有利于缓解压力,达到工作和生活的和谐.结合设计实例分析,讨论了包装趣味化设计的情趣意境营造,艺术设计手法运用和文化因素等几个要点,为提高趣味化包装设计提供参考.     

沧桑人世的真率抒怀——废名后期小说的情感特征

废名是我国现代抒情小说的开拓者之一。对于废名后期的小说,学者较多研究其现实性及禅意的变化,较少涉及小说的情感特征。文章结合废名的人生经历及其文学观的变化,着重探讨废名后期小说的情感特征：真挚率直、理性谐趣。