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1.
采用基于雷诺应力模型与体积函数法的等宽明渠交汇流三维数值模型,对7种交汇角和3种流量比的21种组合工况进行了模拟计算;采用基于主流向流速的等值线法定义分离区,对分离区尺度及其三维形态进行了分析,并根据断面涡量值的计算结果对交汇口下游二次流强度沿程分布规律进行了归纳总结。结果表明:当流量比增大或交汇角减小时,分离区的水平尺寸变小,平面形态变狭长;分离区域平均水深随着流量比或交汇角的增大而降低;交汇口下游二次流强度随着流量比的增大而逐渐减弱;在交汇口附近二次流强度受交汇角影响较大,沿主流方向交汇角影响逐渐降低。  相似文献   
2.
碳化硅结势垒肖特基二极管(SiC JBS)是新一代航天器电推进系统的关键部件,但高能粒子辐射严重威胁其可靠性与稳定性。为揭示其辐射损伤机理,为其抗辐射加固设计与考核评估储备数据,本研究基于加速器开展了先进商用SiC JBS 10~20 MeV中能质子地面辐照实验,并提取器件辐照前后的正向伏安特性、反向伏安特性、电容电压等电学参数及缺陷特性。系统分析器件关键特性随辐照条件的改变规律。结果显示,质子辐照引起了器件肖特基势垒升高、载流子浓度降低,且10 MeV较低能质子导致的位移损伤退化更严重。分析认为,PN结界面缺陷导致高性能商用SiC JBS反向电学性能对中能质子的辐照更加敏感,正向特性相对稳定,辐照生碳缺陷造成载流子去除效应是引起SiC JBS性能退化的主要机制。  相似文献   
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碳化硅金属氧化物半导体场效应管SiC MOSFET(silicon carbide metal oxide semiconductor field effect transistor)以其优异的材料特性成为一种很有前景的高功率密度和高效率器件,而结温是其设计和工作的一个重要参数,也是健康状态的重要指标。为了状态监控的需求,提出一种受自热影响较少的基于准阈值电压的结温提取方法。首先,从理论层面证实了阈值电压VTH与温度有良好的线性关系,具有负的温度敏感度。然后,实验观察了外部驱动电阻RGext对VTH的影响。最后,结合智能驱动提出了获取准阈值电压的电路,实验结果证实了所提方法的可行性。  相似文献   
5.
Background: Within the claudin (CLDN) family, CLDN12 mRNA expression is altered in various types of cancer, but its clinicopathological relevance has yet to be established due to the absence of specific antibodies (Abs) with broad applications. Methods: We generated a monoclonal Ab (mAb) against human/mouse CLDN12 and verified its specificity. By performing immunohistochemical staining and semiquantification, we evaluated the relationship between CLDN12 expression and clinicopathological parameters in tissues from 138 cases of cervical cancer. Results: Western blot and immunohistochemical analyses revealed that the established mAb selectively recognized the CLDN12 protein. Twenty six of the 138 cases (18.8%) showed low CLDN12 expression, and the disease-specific survival (DSS) and recurrence-free survival rates were significantly decreased compared with those in the high CLDN12 expression group. We also demonstrated, via univariable and multivariable analyses, that the low CLDN12 expression represents a significant prognostic factor for the DSS of cervical cancer patients (HR 3.412, p = 0.002 and HR 2.615, p = 0.029, respectively). Conclusions: It can be concluded that a reduced CLDN12 expression predicts a poor outcome for cervical cancer. The novel anti-CLDN12 mAb could be a valuable tool to evaluate the biological relevance of the CLDN12 expression in diverse cancer types and other diseases.  相似文献   
6.
Glycine is an amino acid with unique properties because its side chain is composed of a single hydrogen atom. It confers conformational flexibility to proteins and conserved glycines are often indicative of protein domains involving tight turns or bends. All six beta-type connexins expressed in human epidermis (Cx26, Cx30, Cx30.3, Cx31, Cx31.1 and Cx32) contain a glycine at position 12 (G12). G12 is located about halfway through the cytoplasmic amino terminus and substitutions alter connexin function in a variety of ways, in some cases altering protein interactions and leading to cell death. There is also evidence that alteration of G12 changes the structure of the amino terminus in connexin- and amino acid- specific ways. This review integrates structural, functional and physiological information about the role of G12 in connexins, focusing on beta-connexins expressed in human epidermis. The importance of G12 substitutions in these beta-connexins is revealed in two hereditary skin disorders, keratitis ichthyosis and erythrokeratodermia variabilis, both of which result from missense mutations affecting G12.  相似文献   
7.
朱赛楠  殷跃平  王猛  朱茂  王晨辉  王文沛  李俊峰  赵慧 《岩土工程学报》2021,(4):688-697,I0004,F0003
金沙江结合带是一条以强烈挤压为主的活动性断裂带,带内经强烈侵蚀切割形成褶皱高山与深切河谷地貌,岩体结构复杂破碎,软弱岩层发育,流域性特大高位地质灾害频繁发生。以金沙江色拉滑坡为例,采用现场调查测绘、多期遥感数据分析、InSAR动态观测、物探、地表位移监测等手段,详细分析了色拉滑坡的基本特征、变形过程、形成机理及发展趋势,并结合金沙江水电开发及特殊地质条件探讨了高位堵江滑坡早期识别与灾害风险管理问题。形成认识如下:色拉滑坡前后缘高差693 m,体积约6520×104 m3,属于典型特大高位滑坡。可分为后部下错变形区(Ⅰ)、中部拉裂变形区(Ⅱ)和前部应力集中区(Ⅲ)3个变形区。受地质构造、地层岩性、降雨与河流冲刷侵蚀等作用影响,失稳模式为多级渐进式破坏,未来滑坡前部发生破坏失稳的可能性较大。采用空天地一体化等先进技术手段,可及时识别高位滑坡变形区域与变形量等信息,为此类流域性灾害链防灾减灾提供科学依据。  相似文献   
8.
《Ceramics International》2022,48(1):656-664
Formation of p-n junction was an effective method to improve the photocatalytic performance due to its built-in electric field. However, the electric field was distributed only on the interface between two semiconductors, which was insufficient in comparison to the entire material. In this work, a multilayer TiO2–CoTiO3 p-n junction was designed and fabricated by atomic layer deposition. The charge transport and photoelectrochemical properties of multilayer TiO2–CoTiO3 films of various thicknesses are thoroughly investigated. The PL and electrochemical tests demonstrate that TiO2–CoTiO3 exhibits enhanced charge separation and transport. Additionally, the extra visible light response was achieved by introduction of CoTiO3. Also, theoretical calculations indicate that the electrons prefer to immigrate from TiO2 to CoTiO3 in a multilayer TiO2–CoTiO3 structure. Benefited from the boosted light absorption and charge transfer, the multilayer TiO2–CoTiO3 composite film exhibits a significantly increased photocurrent, much higher than pure TiO2 and a single TiO2–CoO p-n junction. This multilayer p-n junction structure opens a rational and novel way for nanostructure construction in the energy conversion region.  相似文献   
9.
The newborn gut undergoes rapid colonization by commensal microorganisms and possible exposure to pathogens. The contribution of colostrum intake to host protection is well known; however, limited research exists on the intestinal innate immunity corresponding to colostrum intake during the passive immune transfer period in newborn ruminants. The aim of this study was to investigate the changes in bacterial community and expression of genes encoding toll-like receptors (TLR), mucins (MUC), antimicrobial peptides, and tight junctions in the jejunum of lambs that were fed colostrum during the first 24 h of life. Twenty-seven newborn lambs were used in this study, of which 18 lambs were bottle-fed pooled bovine colostrum within the first 2 h after birth to obtain an intake of approximately 8% of body weight. Lambs were slaughtered at 12 (n = 9) and 24 h (n = 9) after birth. The remaining 9 lambs without any feeding were slaughtered at 30 min after birth (0 h). Tissue and ligated segment samples from the jejunum were collected immediately after the lambs were slaughtered. The bacterial profile in the ligated jejunum segment was assessed using amplicon sequencing. The gene expression in the jejunum tissue was determined using quantitative real-time PCR. The relative abundances of Escherichia-Shigella, Lactobacillus, Lactococcus, and Streptococcus increased, whereas those of Sphingomonas, Phyllobacterium, Bradyrhizobium, and Rudaea decreased during the first 24 h of life. Expression of TLR2 and β-defensin 109-like was upregulated at 12 h after birth, but a recovery was detected at 24 h; TLR3, TLR5, LYZ, MUC1, MUC13, MUC20, and CLDN7 showed a higher expression level in samples taken at 24 h than in those taken at 0 h. In addition, expression level of CLDN1, CLDN4, and the junctional adhesion molecule-1 tended to be higher at 24 h than at 0 h after birth. Correlation analysis indicated that TLR2 expression was negatively correlated with the relative abundance of Lactobacillus and Bradyrhizobium, whereas TLR5 expression was positively correlated with the relative abundance of Escherichia-Shigella and Pelagibacterium. These results suggest that TLR, MUC, antimicrobial peptides, and CLDN act together and play an important role in intestinal defense during the passive immune transfer period. They are potentially associated with microbial colonization. The findings from this study provide novel information to elucidate the role of colostrum components in regulating the development of the intestinal mucosal immune barrier in newborn lambs during the passive immune transfer period.  相似文献   
10.
通过灌胃摄入的方式观察贵州凯里红酸汤对高脂血症大鼠模型的小肠上皮脂肪酸吸收蛋白和紧密连接蛋白的调控作用。摄入凯里红酸汤期间测量大鼠的体质量和血脂,摄入11周后测定大鼠小肠上皮的脂肪酸转位酶CD36(FAT/CD36)、脂肪酸转运蛋白(FATP4)、紧密连接相关蛋白Occludin和紧密连接跨膜蛋白ZO-1的表达。结果表明,在高脂血症大鼠模型中,酸汤干预使大鼠的体质量和血脂显著降低(P<0.05),CD36和FATP4表达水平显著降低(P<0.05),ZO-1表达水平显著升高(P<0.05),其水平更接近于正常条件下喂养的阴性组大鼠。酸汤可以抑制大鼠体质量增长,恢复被高脂膳食破坏的小肠上皮紧密连接结构,减少肠道长链脂肪酸的吸收,改善大鼠高脂血症的状况。  相似文献   
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