负载氯喹的骨靶向纳米颗粒打破肿瘤细胞增殖与骨吸收之间的恶性循环

肿瘤细胞增殖与骨吸收之间的恶性循环加剧了骨肿瘤的进展和转移风险.为此,我们设计并制备了聚乙二醇-阿仑膦酸钠修饰的聚多巴胺(PPA)纳米粒子,并在其表面负载自噬抑制剂氯喹(CQ),期望利用该治疗载体(PPA/CQ)打破肿瘤细胞增殖与骨吸收之间的恶性循环,从而有效地治疗骨肿瘤.实验证明,PPA/CQ可以有效地富集到骨组织,...     

基于虚拟气体传感器阵列的肺癌检测电子鼻

提出了一种无创电子鼻诊断肺癌的新方法。该方法结合虚拟声表面波（SAW）传感器阵列的概念和图像识别方法，对肺癌病人、正常人和老慢支病人的呼出气体进行了检测，确定11种挥发性有机成分（VOCs）为肺癌特征气体。此外，在细胞水平上进行研究，证明了肺癌细胞培养液中存在的特征性VOCs是肺癌细胞新陈代谢的产物，可以作为判定特定肺癌细胞的依据，为确定肺癌病人呼吸中的特征性气体提供病理根据。     

LSM下乳癌,乳腺囊性增生症早期恶变及乳腺增生细胞荧光特性的观察

本文报道了乳癌、乳腺囊性增生症早期恶变及乳腺增生细胞在单色激光激发下的自体荧光。结果发现乳癌细胞浆内荧光最强，囊性增生早期恶变细胞次之而乳腺增生细胞浆无荧光。这一荧江特征可为肿瘤早期诊断提供重要依据。     

miR-21的高表达在结直肠癌预后中的meta分析

目的:评价miR-21的高表达与结直肠癌预后的相关性.方法:通过全面检索PubMed、EMBASE、Google scholar、维普、CNKI等数据库,收集关于miR-21的高表达与结直肠癌预后相关性的文献,用meta分析方法评价miR-21的高表达是否与结直肠癌的预后相关.结果:共纳入4篇文献(共783个病例),总生存率(OS)HR的合并值为1.42,95％CI:1.21至1.66,P＜0.05.结论:miR-21的高表达是结直肠癌预后的一个危险因素.     

饮食营养与癌症

饮食的变化与癌症的发病率有很明显的联系,本文着重论述了饮食营养中脂肪、蛋白质、维生素、矿物质同癌症之间的关系。     

艾易舒注射液合并化疗治疗乳腺癌的疗效观察

目的:应用艾易舒注射液治疗乳腺癌术后患者并观察其临床疗效。方法:选择我院确诊为乳腺癌术后患者62例,随机分为治疗组(33例)和对照组(29例),治疗组应用艾易舒注射液50ml加入生理盐水250ml静脉点滴及常规化疗,对照组仅给予常规化疗,3个周期后比较两组CA153值、TSGF的变化及近期疗效、不良反应等指标的差异性。结果:治疗组CAl53及TSGF数值治疗后下降显著,阳性例数远远低于对照组;两组的近期疗效无显著差异,但治疗组的不良反应明显低于对照组。结论:艾易舒注射液在一定程度上可以预防转移和复发,具有抗癌作用。     

Self‐Assembling Prodrugs by Precise Programming of Molecular Structures that Contribute Distinct Stability,Pharmacokinetics, and Antitumor Efficacy

The availability of precisely modulated chemical modifications dramatically affects the physicochemical properties of pristine drugs and should facilitate the amphiphilic self‐assembly of prodrugs into supramolecular nanoprodrugs (SNPs). However, rationally designing such prodrugs to achieve favorable clinical outcomes still remains a challenge. Here, a library of prodrugs through site‐specific attachment of a variety of lipophilic moieties to the antitumor agent SN‐38 (7‐ethyl‐10‐hydroxycamptothecin) is constructed. Taking advantage of the role of hydroxyl groups as solvophilic moieties, these prodrugs exhibit self‐assembly in aqueous environments, allowing for the identification of five prodrugs capable of self‐assembling into SNPs at high drug concentrations. Importantly, in vivo studies demonstrate that the antitumor activity of the SNPs correlates well with their stability and long‐term circulation. In addition, the modular feature of this SNP design strategy offers the opportunity to readily incorporate additional valuable functionalities (e.g., tumor‐specific targeting ligands) to the particle surface, which is further exploited to improve antitumor efficacy in mouse xenograft models. Thus, this structure‐based reconstruction of SN‐38 molecules significantly improves the potency of SNPs for clinical use. These results also provide novel mechanistic insights into the rational design of prodrugs.     

HIV相关癌症的动力学模型研究(英文)

本文通过建立两个动力学模型,研究了HIV感染者中癌症的高发现象。我们分别研究了其平衡态的存在性及稳定性。对正平衡态还发现了Hopf分支的存在,并发现随着分支参数的变化,系统出现了周期解与混沌交替出现的现象。