Sarcopenia: Molecular Pathways and Potential Targets for Intervention

Aging is associated with sarcopenia. The loss of strength results in decreased muscle mass and motor function. This process accelerates the progressive muscle deterioration observed in older adults, favoring the presence of debilitating pathologies. In addition, sarcopenia leads to a decrease in quality of life, significantly affecting self-sufficiency. Altogether, these results in an increase in economic resources from the National Health Systems devoted to mitigating this problem in the elderly, particularly in developed countries. Different etiological determinants are involved in the progression of the disease, including: neurological factors, endocrine alterations, as well as nutritional and lifestyle changes related to the adoption of more sedentary habits. Molecular and cellular mechanisms have not been clearly characterized, resulting in the absence of an effective treatment for sarcopenia. Nevertheless, physical activity seems to be the sole strategy to delay sarcopenia and its symptoms. The present review intends to bring together the data explaining how physical activity modulates at a molecular and cellular level all factors that predispose or favor the progression of this deteriorating pathology.     

遥感技术在水电站地址勘察中的应用

基于降雨径流模型确定水电站地址勘察已成为水资源评价中的一个重要课题。随着卫星技术的发展，遥感、地理信息系统能够快速地确定水电站地址勘察。选取位于云南省中部滇中盆地地区澜沧江流域作为研究区，利用遥感和地理信息系统技术，从数字高程模型角度出发，确定了流域尺度、流域边界和最小面积、平均高程、流域平均坡度等水文信息。运用分辨率为2.5 m的IRS-P5立体卫星数据导出数字高程模型。该数字高程模型用于生成盆地的流向和流量累积图。通过对这些图像的分析得出了综合排水网；利用地形资料，包括流域面积、平均流域高程和降雨资料的有限点观测值，推导出整个流域的回归模型，使用平均面雨量计算其雨量分布图，结合Kriging统计方法生成子流域验证这个回归模型，并给出了水电站地址勘察建设地点。     

基于GsMAP的尼洋河流域降水时空分布特征研究

鉴于尼洋河地区实测降雨资料缺乏,卫星降雨产品具有显著优势,基于GsMAP降雨产品数据和地面观测站点数据,利用降雨量年内分配特征的δ方法建立卫星降雨校正公式,分析流域降雨量的时空分布特征。结果表明,实测站点月降雨量校正结果较好,相关系数达0.954,年尺度的站点降雨相关系数为0.54,降雨量空间分布呈现出自西向东递增的特点。卫星降雨观测在西部地区存在低估,东部地区有一定程度的高估,在降雨梯度分布上,流域在3500~4000m高程段降雨量呈上升趋势,其他高程段均为显著下降,整体变化率为-104mm/km。流域的年均面平均降雨量为699mm,降雨多集中于夏季,且有逐年增加趋势。     

Study on Thermal Deformation Measurement of Optical Remote Sensing Satellite Platform Based on Machine Vision

To solve the special requirements of the high orbit optical remote sensing-satellite for the thermal deformation of the platform, the thermal deformation test and measurement scheme of the satellite platform is designed. Through the comparative analysis of test results, the rationality of the thermal deformation design of the platform structure is verified. The results of thermal deformation measurement show that the maximum deformation of A camera mounting surface is 57.5~〃, and the maximum deformation of B camera mounting surface points to 79.3~〃, which can be used as the basis for thermal deformation prediction of satellite during the orbit operation.     

Modeling and analysis for multilayered complex communication network of satellite navigation system

This study is extended to construct the network model, the node model, and the link model of complex communication network for satellite navigation system (CCN‐SNS) based on the hierarchical architecture. Firstly, a method called snapshots was proposed to describe the dynamic topology for CCN‐SNS; secondly, another method was put forward to model the different nodes of the CCN‐SNS; thirdly, the different links between every two different nodes were modeled. Therefore, based on the OPNET tools, a simulation for the CCN‐SNS, which contains the models that proposed earlier used to analyze the navigation accuracy and network transmission performance, was performed.     

Lamin-Related Congenital Muscular Dystrophy Alters Mechanical Signaling and Skeletal Muscle Growth

Laminopathies are a clinically heterogeneous group of disorders caused by mutations in the LMNA gene, which encodes the nuclear envelope proteins lamins A and C. The most frequent diseases associated with LMNA mutations are characterized by skeletal and cardiac involvement, and include autosomal dominant Emery–Dreifuss muscular dystrophy (EDMD), limb-girdle muscular dystrophy type 1B, and LMNA-related congenital muscular dystrophy (LMNA-CMD). Although the exact pathophysiological mechanisms responsible for LMNA-CMD are not yet understood, severe contracture and muscle atrophy suggest that mutations may impair skeletal muscle growth. Using human muscle stem cells (MuSCs) carrying LMNA-CMD mutations, we observe impaired myogenic fusion with disorganized cadherin/β catenin adhesion complexes. We show that skeletal muscle from Lmna-CMD mice is unable to hypertrophy in response to functional overload, due to defective fusion of activated MuSCs, defective protein synthesis and defective remodeling of the neuromuscular junction. Moreover, stretched myotubes and overloaded muscle fibers with LMNA-CMD mutations display aberrant mechanical regulation of the yes-associated protein (YAP). We also observe defects in MuSC activation and YAP signaling in muscle biopsies from LMNA-CMD patients. These phenotypes are not recapitulated in closely related but less severe EDMD models. In conclusion, combining studies in vitro, in vivo, and patient samples, we find that LMNA-CMD mutations interfere with mechanosignaling pathways in skeletal muscle, implicating A-type lamins in the regulation of skeletal muscle growth.     

基于GF-1数据的三峡库区水体信息精细化提取

为实现江河类狭长型水体信息的精细化提取，利用GF-1卫星数据，采用支持向量机和目视解译相结合的方法对三峡库区及重庆市水体信息进行了精细化提取。使用总体分类精度、Kappa系数、错分误差、漏分误差、制图精度和用户精度等指标对库区水体信息粗提取结果进行验证分析。结果表明:4个试验区水体提取的总体分类精度均超过90%，除试验区4的Kappa系数为0.884 1以外，其余试验区均超过0.9，提取精度较高。结合目视解译的方法，在粗提取结果的基础上对各问题进行精细化处理，得到精度高、完整性好的三峡库区以及重庆市水体信息数据，可为后续该区域的精细化遥感业务开展提供有效资料。     

可重构智能表面辅助的四元数调制无线通信系统

四元数调制(Quaternion Modulation,QMod)是一种新型高传输速率的极化调制(Polarized Modulation,PMod)技术,是未来卫星通信系统中极具潜力的多元调制方案之一。QMod将数据块分成4块,其中两块是传输数据信号,另外两块则映射到极化状态部分。每个极化状态块均有一位比特,那么它们可以产生4个极化状态组合。这些状态组合可以用来确定传输数据块在四元数4个不同维度中的位置,从而获得两位额外的传输比特。相比于传统的PMod技术,QMod有着更高的频谱效率。为了进一步挖掘QMod的潜力,介绍了由可重构智能表面(Reconfigurable Intelligent Surface,RIS)辅助的QMod系统,同时推导了该系统的平均误码率理论上界,并在瑞利信道下进行了BER性能仿真。仿真结果表明,RIS辅助的PMod或者QMod系统即便在较低的SNR情况下仍有良好的BER性能,并且随着RIS单元数的增多,其BER性能会逐步提升。     

WIDESTARII卫星移动通信方案研究

WIDESTAR II系统为了更好的满足用户需求,在WIDESTAR系统的基础之上对移动终端、基站设备以及核心网节点进行了再次开发,从而实现了更高的传输速率以及与IMS或其他通用IP技术的灵活兼容。本文中,将首先对WIDESTAR II系统进行简要的介绍与分析,然后,对此系统所采用频谱效率提高方法、IP兼容技术以及时延降低策略等卫星移动通信机制进行研究与验证。