基于LabVIEW的高分辨光声显微成像系统设计

基于图形化编程语言的虚拟仪器开发软件LabVIEW,设计一套高分辨光声显微成像系统,实现步进电机运动扫描,数据采集、转移和存储,图像实时重建显示等多功能协调工作。使用该系统进行了小鼠活体耳部血管成像实验,其微血管脉络得到完整呈现。结果证明,该系统成像性能稳定,可操作性强,对于其他生物医学成像系统的构建具有广泛的参考价值。     

浅谈3D打印技术在生物医学领域的应用与发展

3D打印技术能够进行个性化定制,给生物医学领域带来了新的技术突破。本文首先概述了3D打印技术,之后就其在生物医学领域的应用和发展前景展开了论述。     

《生物医学工程研究》2015年征订启事

<正>《生物医学工程研究》(刊号:ISSN1672-6278/CN37-1413/R)是由山东省科协主管、山东生物医学工程学会等主办的中国科技核心期刊。主要栏目有:论著、科研简报、新技术与新方法、专题讲座、新产品评价、综述等。主要刊登生物医学工程领域的最新科技成果。本刊为万方数据资源系统收录期刊、中文生物医学期刊文献数据库收录期刊、中国生物医学期刊引文数据库收录期刊等。     

金纳米的制备及其应用研究进展

介绍了金纳米的光学性质及制备的研究进展,总结了空心金纳米球、金纳米棒及金纳米簇在食品检测、催化、有毒有害物质的检测及生物医学领域的显著应用。并对今后的研究重点进行了展望。     

星形聚合物的合成及生物医学应用研究进展

星形聚合物作为一种非线形聚合物,具有广阔的研究意义和应用前景,本文介绍了星形聚合物的结构、分类及通过活性聚合制备星形聚合的不同合成方法,并结合最新研究综述了星形聚合物在药物传递、基因传递和成像诊断等生物医学领域的研究进展及应用情况。     

Research progress on chemical modification of silk fibroin and its applications北大核心CSCD

Mulberry silk is composed of the two major parts of two triangle-like silk fibroin fibers and sericin covering the fibers and a few lipids. After removing the sericin on the raw silk what is left is the silk fibroin fiber. Silk fibroin is the main part of silk accounting for about 75% of the total weight. Silk fibroin contains 18 natural amino acids such as glycine Gly alanine Ala serine Ser serine aspartic acid Asp and tyrosine Tyr . The secondary structure of silk fibroin has three main conformations α-helix β-fold and random coil. Under certain conditions the three conformations can transform into each other and change the mechanical properties of the silk fibroin material. Silk fibroin extracted from silk fiber is a natural polymer with biocompatibility and biodegradability. It can be further processed into different forms of materials nanoparticles films hydrogels sponges etc. It has been applied in many fields such as biomedicine and cosmetics. In order to meet the needs of different fields researchers have conducted further chemical modification treatment based on the original excellent properties of silk fibroin. Meanwhile the active groups on various amino acid residues in silk fibroin also provide chemical reaction sites for the chemical modification of silk fibroin. The chemical modification methods of silk fibroin mainly include amino acid residue modification macromolecular grafting modification and crosslinking reaction modification. Among them amino acid residue modification can modify protein amino acid residues by chemical reagents and some groups can be introduced into the side chains of silk fibroin macromolecules. Grafting modification of silk fibroin macromolecules is one of the main means to bind functional compounds to silk fibroin macromolecular chains. The properties of grafted silk fibroin are affected by the type and grafting rate of the grafts. The chemical crosslinking reaction modification of silk fibroin macromolecules is to make the macromolecular chains connected by covalent bonds and form a network structure by means of crosslinking agents enzymes or ultraviolet irradiation. The cross-linking reaction can not only form covalent bonds within and between the molecular chains of silk fibroin thus changing its structural properties and improving its stability but be used to form covalent bonds with other polymers. At present the chemical modification of silk fibroin is mainly applied in the fields of silk textiles biomedicine and environmental science. In the field of silk textiles graft copolymerization modification of vinyl and other monomers crosslinking agent modification and other methods are used to overcome the shortcomings of silk like being easy to wrinkle. The graft modified monomers mainly include ethylene methacrylate and methylacrylamide. The active groups on crosslinking agents such as polycarboxylic acid / anhydride and epoxide are covalently combined with carboxyl hydroxyl and amino groups on macromolecules of silk fibroin to improve the wrinkle resistance of silk fabrics. In the field of biomedicine silk fibroin materials with appropriate chemical modification have better biological activity drug delivery ability antimicrobial properties and mechanical properties. The optimization of these properties enables silk fibroin materials to show great potential in drug control delivery tissue regeneration and wound repair. The applied research in the field of environmental science mainly focuses on the adsorption separation and catalysis of impurities in water. Therefore the modification of amino acid residues grafting and cross-linking of protein macromolecules can change some important properties of silk fibroin and meet the requirements of various applications and functionalization of silk fibroin. In many fields of chemical modification and application of silk fibroin protein fruitful results have been achieved which has laid a good foundation for the further development of related fields and also shows that the chemical modification of silk fibroin material has great potential and application prospects. However there are still some problems that need to be overcome and further improved in the current chemical modification methods such as mild modification conditions and accurate adjustment of the degree of modification which will be the research direction of related fields in the future. © 2022 Authors. All rights reserved.     

聚氟乙烯薄膜

新材料是国家七大战略性新兴产业之一．也是我国石化和化学工业加快转变发展方式的重要着力点,并且与能源、信息、装备制造、节能环保、生物医学等产业密切相关。目前,新材料已被列入国家、各级地方政府以及生产企业的规划重点,投资者重点研究的热点领域。     

基于微流控的现代生物医学检测技术概述

首先介绍了微泵和微阀等常用的微流控器件,然后介绍了利用微流控技术进行片上预处理的方法,包括细胞分离、细胞裂解和微流控富集技术。最后,对微流控在免疫检测中的应用进行了介绍。现代医学检测需要一种全自动、集成化、低成本并且易于操作的微流控系统,从这些方面考虑,给出了微流控生物芯片的一些改进方向。     

熔体静电纺丝技术及其在生物医学中的应用

熔体静电纺丝技术不使用溶剂,可制备连续的超细纤维,在生物医学领域有着广泛的应用。从流体黏度、射流特点、纤维直径、纺丝效果方面比较了熔体静电纺丝与溶液静电纺丝的差异;介绍了近年来熔体静电纺丝的技术进展,如激光加热熔体静电纺丝技术、同轴熔体静电纺丝技术,以及熔体静电纺丝直写技术等;综述了熔体静电纺丝技术在组织工程、伤口敷料和药物释放方面的应用;指出熔体静电纺丝应进一步优化加工工艺,获得具有适度自粘结结构的支架,从而提高其应用性。