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排序方式: 共有313条查询结果,搜索用时 187 毫秒
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Erji Gao Yao Wang Pengli Wang Qianyi Wang Yuxuan Wei Daiying Song Huangfang Xu Jinghao Ding Yong Xu Huitang Xia Ru Chen Liang Duan 《Advanced functional materials》2023,33(14):2212830
A highly biomimetic neotrachea with C-shaped cartilage rings has promising clinical applications in the treatment of circumferential tracheal defects (CTDs) owing to its structure and physiological function. However, to date, most fabricated tracheal cartilages are O-shaped. In this study, finite element analysis demonstrates C-shaped cartilage rings that exhibit better compliance than O-shaped. Hydrogel is developed using methacryloyl-modified decellularized Wharton's jelly matrix (DWJMA) for the regeneration of C-shaped cartilage rings. This novel hydrogel possesses adjustable physicochemical properties and favorable cytocompatibility. When loaded with chondrocytes, DWJMA hydrogels support the optimal cartilage regeneration both in vitro and in vivo. More importantly, a highly biomimetic neotrachea simultaneously simulating the structural and physiological properties of the normal trachea is regenerated via modular assembly of several individual C-shaped cartilage rings. The results demonstrate the highly biomimetic neotrachea have better patency (88.6 ± 6.1% vs 74.4 ± 9.4%, p < 0.05), improve the survival rate, alleviate weight loss and mucoid impaction, than its O-shaped counterpart when used for the treatment of CTDs in a rabbit model. Therefore, this study proposes a novel hydrogel for the regeneration of C-shaped cartilage and provides new insights into the treatment of CTDs using a highly biomimetic neotrachea with C-shaped cartilage rings. 相似文献
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《Food Control》2016
A simple and rapid multi-class multi-residue analytical method was developed for the screening and quantification of veterinary drugs in royal jelly by ultra performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS). A total of 90 veterinary drugs investigated belonged to more than 14 families such as lincomycins, macrolides, sulfonamides, quinolones, tetracyclines, β-agonists, β-lactams, sedatives, β-receptor antagonists, sex hormones, glucocorticoids, nitroimidazoles, benzimidazoles, nitrofurans, and the others. A modified quick, easy, cheap, effective, rugged, and safe (QuEChERS) procedure was used for the sample preparation without solid-phase extraction step. The linearity, sensitivity, accuracy, repeatability, and reproducibility of the method were fully validated. The response of the detector was linear for each target compounds in wide concentration range (at least, two orders of magnitude) with correlation coefficient (R2) of 0.9921–0.9999. The range of the limit of quantification for these compounds in the royal jelly ranged from 0.21 to 20 μg/kg. The repeatability and reproducibility were in the range of 3.01–11.6% and 5.97–14.9%, respectively. The average recoveries ranged from 70.21 to 120.1% with relative standard deviation of 1.77–9.90% at three concentration levels. For the screening method, the data of the precursor and product ions of the target analytes were simultaneously acquired under the All Ions MS/MS mode in a single run. A homemade database including the elemental composition, accurate masses, retention time, isotopic pattern data of the target ions the characteristic in-source fragment ions was utilized for the confirmation and identification of the target compounds. The applicability of the screening method was verified by applying to real royal jelly samples, and certain veterinary drugs were detected in some cases. 相似文献
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调制生肉馅的主料普遍选用的是猪夹心肉,以冷却肉最佳,并随着肉的加工细度的增加,生肉馅的口感变得更好。生肉馅风味的形成,除了受生肉自身所含风味物质的影响外,还受调辅料如葱、姜、料酒、食盐、酱油、白糖、味精、水的影响,也受皮冻中大量的风味物质的影响,还受生肉馅的调制方法如调味品投放次序、调馅时的搅拌温度和方法、皮冻加入量和加入时机的影响,以及加热熟制对风味形成的影响。 相似文献
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苦瓜保健果冻工艺技术的研究 总被引:4,自引:1,他引:4
本文研究了以苦瓜汁、卡拉胶、魔芋胶、环状糊精为主要原料生产苦瓜保健果冻的生产工艺,通过试验确定了最佳工艺参数。苦瓜汁的适宜用量为6%,将苦瓜块在沸水中烫漂30s后,放入料水比1:3的0.1%柠檬酸 o.05%异抗坏血酸 1%食盐的护色液中,可保持苦瓜汁的色泽。在果冻中添加0.3%的β-环状糊精,配合苦瓜块轻微烫漂,可较好解决产品的苦味问题。试验还确定了苦瓜保健果冻的最佳配方。 相似文献
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以沙棘汁、枸杞子汁、木糖醇为主要原料,并配以其它辅料,研究沙棘枸杞子无糖果冻的最佳配方。通过单因素试验和正交试验确定了果冻的最佳配方:明胶1.0%,木糖醇11%,沙棘汁9%和枸杞汁8%,得到桔黄色,口感爽滑,酸甜可口的沙棘枸杞子无糖果冻,具有浓郁的沙棘和枸杞子风味。 相似文献