声音的掩蔽效应及其应用

根据声音掩蔽作用的特点和规律，分析掩蔽现象对听闻条件的影响，提出它在环境噪声控制中的应用方法。     

蒙砂粉熟化过程与蚀刻玻璃表面的研究

固体蒙砂粉的熟化质量是决定玻璃蚀刻效果的重要因素。用X射线衍射（XRD）、能谱仪（EDS）、拉曼光谱、粘度计、Zeta电位和碱滴定等方法研究了用柠檬酸和氟化氢铵为主要成分配制的蒙砂粉的理化性质随熟化时间的变化规律,考察和评价了熟化时间对GG6手机盖板玻璃蚀刻效果的影响。结果表明：熟化时间为36 h,得到的熟化液的黏度和氢离子浓度最大,GG6玻璃蚀刻后的粗糙度为265 nm、雾度为84%、透光率为92.4%、光泽度为11.7%,符合工业上手机玻璃盖板的蚀刻加工质量要求,蚀刻后的GG6玻璃表面形成一层微量的氟硅酸物晶体,构成的微纳蚀孔结构更均匀。测定蒙砂液的理化性质能有助于更好地了解蒙砂粉的熟化过程,对蒙砂粉蚀刻工艺具有指导作用,提高玻璃防眩工艺的生产效率。     

Combined FRM and GDFT filter bank designs for improved nonuniform DSA channelisation

Multistandard channelisation for base stations is a big application of generalised discrete Fourier transform modulated filter banks (GDFT‐FBs) in digital communications. For technologies such as software‐defined radio and cognitive radio, nonuniform channelisers must be used if frequency bands are shared by different standards. However, GDFT‐FB‐based nonuniform channelisers can suffer from high filter orders when applied to wideband input signals. In this paper, various combinations of GDFT‐FB with the frequency response masking technique are proposed and evaluated for both uniform and nonuniform channelisation applications. Results show that the proposed techniques achieve savings in both the number of filter coefficients and the number of operations per input sample. Copyright © 2015 John Wiley & Sons, Ltd.     

Nanosponge-based pediatric-controlled release dry suspension of Gabapentin for reconstitution

Abstract

Context: Gabapentin was selected to formulate oral controlled release dry suspension because of short biological half life of 5–7?h and low bioavailability (60%). Gabapentin is a bitter drug so an attempt was made to mask its taste.

Objective: To formulate and evaluate controlled release dry suspension for reconstitution to increase the bioavailability and to control bitter taste of drug.

Materials and methods: Cyclodextrin based nanosponges were synthesized by previously reported melt method. The nanosponge–drug complexes were characterized by FTIR, DSC and PXRD as well as evaluated for taste and saturation solubility. The complexes were coated on Espheres by a suspension layering technique followed by coating with ethyl cellulose and Eudragit RS-100. A dry powder suspension for reconstitution of the microspheres was formulated and evaluated for taste, redispersibility, in vitro dissolution, sedimentation volume, leaching and pharmacokinetics.

Results and discussion: The complexes showed partial entrapment of drug nanocavities. Significant decrease in solubility (25%) was observed in the complexes than pure drug in different media. The microspheres of nanosponge complexes showed desired controlled release profile for 12?h. Insignificant drug leaching was observed in reconstituted suspension during storage for 7 days at 45?°C/75% RH. Nanosponges effectively masked the taste of Gabapentin and the coating polymers provided controlled release of the drug and enhanced taste masking. The results of in vivo studies showed increase in bioavailability of controlled release suspension by 24.09% as compared to pure drug.

Conclusion: The dry powder suspension loaded with microspheres of nanosponges complexes can be proposed as a suitable controlled release drug delivery for Gabapentin.     

教室声学环境的分析及改善

对于教室内声学环境的要求,国内及国外一些有关规范都只停留在中频段(500～1 000 Hz)。这样的要求是不够的。在这样的声学环境中,教师健康和学生听课效果均受到影响。文章分析了达到优良室内声学环境的几个重要因素,着重减低低频噪声和控制低频混响时间。利用简单的吸声构件,得到几乎平直的混响时间频率特性。叙述了"掩蔽效应"对中、高频的影响并叙述了"哈斯效应"及在声学处理时要利用有利反射声的注意事项。为得到室内优良的音质环境,提出建议并给出工程实践结果的实例。     

Variable-dimensional vector modulation for perceptual-based DWT blind audio watermarking with adjustable payload capacity

A variable-dimensional vector modulation (VDVM) scheme is introduced to maximize the efficiency of the norm-space DWT-based blind audio watermarking technique. This flexible scheme allows the watermarking algorithm to reach a balance between robustness and capacity, while the imperceptivity is always ensured. The imperfection of applying quantization index modulation in the open-loop case has been rectified. The effectiveness of the proposed scheme is proven using the perceptual evaluation of audio quality (PEAQ) and bit error rates of recovered watermarks under various signal processing attacks. Experimental results show that the proposed VDVM scheme is comparable to other recently developed methods in robustness and imperceptivity even at a capacity as high as 301.46 bps. Such a capacity can be further doubled by halving the dimension of the involved DWT vector, while the robustness is still maintained at a satisfactory level.     

Formulation studies for mirtazapine orally disintegrating tablets

Abstract

Objective: Orally disintegrating tablets (ODTs) recently have gained much attention to fulfill the needs for pediatric, geriatric, and psychiatric patients with dysphagia. Aim of this study was to develop new ODT formulations containing mirtazapine, an antidepressant drug molecule having bitter taste, by using simple and inexpensive preparation methods such as coacervation, direct compression and to compare their characteristics with those of reference product (Remereon SolTab).

Materials and methods: Coacervation method was chosen for taste masking of mirtazapine. In vitro characterization studies such as diameter and thickness, weight variation, tablet hardness, tablet friability and disintegration time were performed on tablet formulations. Wetting time and in vitro dissolution tests of developed ODTs also studied using 900?mL 0.1?N HCl medium, 900?mL pH 6.8 phosphate buffer or 900?mL pH 4.5 acetate buffer at 37?±?0.2?°C as dissolution medium.

Results: Ratio of Eudragit® E-100 was chosen as 6% (w/w) since the dissolution profile of A1 (6% Eudragit® E-100) was found closer to the reference product than A2 (4% Eudragit® E-100) and A3 (8% Eudragit® E-100). Group D, E and F formulations were presented better results in terms of disintegration time. Dissolution results indicated that Group E and F formulations showed optimum properties in all three dissolution media.

Discussion: Formulations D1, D4, D5, E3, E4, F1 and F5 found suitable as ODT formulations due to their favorable disintegration times and dissolution profiles.

Conclusion: Developed mirtazapine ODTs were found promising in terms of showing the similar characteristics to the original formulation.     

Use of polymers for taste-masking pediatric drug products

Many drugs are bitter and overcoming this bitter taste is a major barrier in developing a successful product, especially for pediatric patients. Approaches to mask taste include changing taste perception, creating a physical barrier to separate the drug from interacting with taste buds, and changing drug solubility. This review is focused on polymers and the different ways these materials are used to achieve taste masking. Attention is given to systems that are easily swallowed, as swallowability is another concern in developing palatable products for pediatrics. Variables that should be considered when selecting a taste-masking approach are also presented.