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排序方式: 共有721条查询结果,搜索用时 15 毫秒
1.
Matteo Di Giosia Alice Soldà Markus Seeger Andrea Cantelli Fabio Arnesano Maria I. Nardella Vincenzo Mangini Francesco Valle Marco Montalti Francesco Zerbetto Stefania Rapino Matteo Calvaresi Vasilis Ntziachristos 《Advanced functional materials》2021,31(20):2101527
Fullerenes are candidates for theranostic applications because of their high photodynamic activity and intrinsic multimodal imaging contrast. However, fullerenes suffer from low solubility in aqueous media, poor biocompatibility, cell toxicity, and a tendency to aggregate. C70@lysozyme is introduced herein as a novel bioconjugate that is harmless to a cellular environment, yet is also photoactive and has excellent optical and optoacoustic contrast for tracking cellular uptake and intracellular localization. The formation, water-solubility, photoactivity, and unperturbed structure of C70@lysozyme are confirmed using UV-visible and 2D 1H, 15N NMR spectroscopy. The excellent imaging contrast of C70@lysozyme in optoacoustic and third harmonic generation microscopy is exploited to monitor its uptake in HeLa cells and lysosomal trafficking. Last, the photoactivity of C70@lysozyme and its ability to initiate cell death by means of singlet oxygen (1O2) production upon exposure to low levels of white light irradiation is demonstrated. This study introduces C70@lysozyme and other fullerene-protein conjugates as potential candidates for theranostic applications. 相似文献
2.
David L. Hoover 《Computers and the Humanities》2003,37(2):151-178
This article examines the usefulness ofvocabulary richness for authorship attributionand tests the assumption that appropriatemeasures of vocabulary richness can capture anauthor's distinctive style or identity. Afterbriefly discussing perceived and actualvocabulary richness, I show that doubling andcombining texts affects some measures incomputationally predictable but conceptuallysurprising ways. I discuss some theoretical andempirical problems with some measures anddevelop simple methods to test how wellvocabulary richness distinguishes texts bydifferent authors. These methods show thatvocabulary richness is ineffective for largegroups of texts because of the extremevariability within and among them. I concludethat vocabulary richness is of marginal valuein stylistic and authorship studies because thebasic assumption that it constitutes awordprint for authors is false. 相似文献
3.
Ellen Spolsky 《Computers and the Humanities》1993,27(5-6):323-329
Olsen is right to note what can be done with a good theory and the right machine. His particular theory, however, is not transferable to literary studies. If we need a new model, I would suggest that cognitive science can provide a few interesting ones. I have begun to do some work based on David Marr's VISION, in which he hypothesizes two levels of processing within the visual module. My speculation has been on the parallel existence of distinguishable levels of conceptual or language organization which would correspond to the viewer and object centered perspectives Marr describes for vision. I propose to explore the possibility that we may find here the model for the existence of stylistic individualism within overarching historical stylistic generalizations, and even more, that this may be what feminists are searching for when they try to resist being coopted by the masculine language of objectivity.
Ellen Spolsky teaches English literature and literary theory and is the Director of the Lechter Institute for Literary Research at Bar-Ilan University, Israel. Her latest book is Gaps in Nature: Literary Interpretation and the Modular Mind(SUNY Press, 1993). 相似文献
4.
Wilcox Teresa; Woods Rebecca; Chapa Catherine; McCurry Sarah 《Canadian Metallurgical Quarterly》2007,43(2):479
Recent research indicates that by 4.5 months, infants use shape and size information as the basis for individuating objects but that it is not until 11.5 months that they use color information for this purpose. The present experiments investigated the extent to which infants' sensitivity to color information could be increased through select experiences. Five experiments were conducted with 10.5- and 9.5-month-olds. The results revealed that multimodal (visual and tactile), but not unimodal (visual only), exploration of the objects prior to the individuation task increased 10.5-month-olds' sensitivity to color differences. These results suggest that multisensory experience with objects facilitates infants' use of color information when individuating objects. In contrast, 9.5-month-olds did not benefit from the multisensory procedure; possible explanations for this finding are explored. Together, these results reveal how an everyday experience--combined visual and tactile exploration of objects--can promote infants' use of color information as the basis for individuating objects. More broadly, these results shed light on the nature of infants' object representations and the cognitive mechanisms that support infants' changing sensitivity to color differences. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
5.
本文基于普通PID控制器和人工智能的理论,针对液压电梯速度控制系统非线性和建模困难等特点。采用了一种多模式智能PID控制算法,它结合了普通PID控制器的优点。应用实例显示了这种控制方法的有效性。 相似文献
6.
Katerina Mangaroska Roberto Martinez-Maldonado Boban Vesin Dragan Gašević 《Journal of Computer Assisted Learning》2021,37(4):1030-1047
Multimodal data have the potential to explore emerging learning practices that extend human cognitive capacities. A critical issue stretching in many multimodal learning analytics (MLA) systems and studies is the current focus aimed at supporting researchers to model learner behaviours, rather than directly supporting learners. Moreover, many MLA systems are designed and deployed without learners' involvement. We argue that in order to create MLA interfaces that directly support learning, we need to gain an expanded understanding of how multimodal data can support learners' authentic needs. We present a qualitative study in which 40 computer science students were tracked in an authentic learning activity using wearable and static sensors. Our findings outline learners' curated representations about multimodal data and the non-technical challenges in using these data in their learning practice. The paper discusses 10 dimensions that can serve as guidelines for researchers and designers to create effective and ethically aware student-facing MLA innovations. 相似文献
7.
基于CCA的人耳和侧面人脸特征融合的身份识别* 总被引:2,自引:0,他引:2
鉴于人耳和人脸特殊的生理位置关系,从非打扰识别的角度出发,提出仅采集侧面人脸图像,利用典型相关分析的思想提取人耳和侧面人脸的关联特征,进行人耳和侧面人脸在特征层的融合.实验结果表明,此方法与单一的人耳或侧面人脸特征识别比较,识别率得到提高. 相似文献
8.
Tianyi Liu Zuxuan Wu Jingjing Chen Yugang Jiang 《International Journal of Software and Informatics》2023,13(2):143-155
Most existing vision-language pre-training methods focus
on understanding tasks and use BERT-like loss functions (masked language
modeling and image-text matching) during pre-training. Despite their good
performance in the understanding of downstream tasks, such as visual
question answering, image-text retrieval, and visual entailment, these
methods cannot generate information. To tackle this problem, this study
proposes Unified multimodal pre-training for Vision-Language understanding
and generation (UniVL). The proposed UniVL is capable of handling both
understanding tasks and generation tasks. It expands existing pre-training
paradigms and uses random masks and causal masks simultaneously, where
causal masks are triangular masks that mask future tokens, and such
pre-trained models can have autoregressive generation abilities. Moreover, several vision-language understanding tasks are turned into text generation
tasks according to specifications, and the prompt-based method is employed
for fine-tuning of different downstream tasks. The experiments show that
there is a trade-off between understanding tasks and generation tasks when
the same model is used, and a feasible way to improve both tasks is to use
more data. The proposed UniVL framework attains comparable performance to
recent vision-language pre-training methods in both understanding tasks and
generation tasks. Moreover, the prompt-based generation method is more
effective and even outperforms discriminative methods in few-shot scenarios. 相似文献
9.
当今社会已经步入了一个数字化和信息化的时代,随着人们的交流方式逐渐由文字向图像化转变,话语分析的研究范围也随之延伸到语言文字之外的图片、声音、颜色等社会符号。文章运用社会符号学框架下的视觉语法理论分析了2010年上海世博会吉祥物-海宝这个多模态语篇,说明除语言文字以外的其他社会符号也是意义的源泉。 相似文献
10.