儿童用品TBT通报数据可视化预警研究

探索采用数据可视化技术分析儿童用品TBT通报数据,以可视化图形图像呈现通报热点并揭示趋势信息,提出对策与建议,助力为儿童用品产业升级、TBT预警数据分析和信息传播工作提供新思路,提高中小企业的国外市场准入机会。     

云杉八齿小蠹Ips typographus L.虚拟模型构建方法研究

本文以云杉八齿小蠹Ips typographus Linnaeus为例,经标本选取,观察虫体整体形态,绘制整体结构草图,电子显微镜观察局部、得到局部数字图像,分别建立虫体每一部分的高精度细节。把模型每部分拼装在一起组成整体模型,构建出了云杉八齿小蠹三维虚拟昆虫数字化模型。     

Lean production system design for fishing net manufacturing using lean principles and simulation optimization

Value stream mapping (VSM) is a useful tool for describing the manufacturing state, especially for distinguishing between those activities that add value and those that do not. It can help in eliminating non-value activities and reducing the work in process (WIP) and thereby increase the service level. This research follows the guidelines for designing future state VSM. These guidelines consist of five factors which can be changed simply, without any investment. These five factors are (1) production unit; (2) pacemaker process; (3) number of batches; (4) production sequence; and (5) supermarket size. The five factors are applied to a fishing net manufacturing system. Using experimental design and a simulation optimizing tool, the five factors are optimized. The results show that the future state maps can increase service level and reduce WIP by at least 29.41% and 33.92% respectively. For the present study, the lean principles are innovatively adopted in solving a fishing net manufacturing system which is not a well-addressed problem in literature. In light of the promising empirical results, the proposed methodologies are also readily applicable to similar industries.     

黑龙江省节水增粮行动(2012—2015年)实施方案

文章通过对黑龙江省高效节水现状,存在问题的分析,结合黑龙江省高效节水发展的支撑能力,阐述黑龙江省节水增粮目标、任务及总体布局,为黑龙江省2012—2015年节水增粮实施提供依据。     

青年医学工作者科普能力培养新模式

为了培养青年医师运用医学科普语言传播医学知识的能力，向社会提供更优质、可及的健康知识，改善医患关系，促进社会和谐；同时出于向社区、媒体推送一批优秀青年医学科普人才的考虑，本文在总结北京协和医院培养青年医务人员医学科普能力经验的基础上，尝试构建一套适合大型公立医院（尤其是教学医院）培养青年医务人员医学科普能力的新模式——“科普训练营”。本文旨在系统介绍该模式的产生背景、实践经验及初期效果，阐释实施后的重要意义，及实施过程中的挑战与应对策略。     

气管上段腺样囊性癌的临床病理

目的　探讨气管上段腺样囊性癌的临床病理特征及诊断和鉴别诊断要点。方法　收集2000年1月至2014年2月在北京协和医院确诊的4例气管上段腺样囊性癌病例，通过光镜、免疫组织化学及组织化学染色分析其临床病理特征、免疫组织化学特点、诊断及鉴别诊断要点。结果　4例气管上段腺样囊性癌患者中，男1例，女3例，平均年龄47岁(38~57岁）；既往均无腺样囊性癌病史，1例患者既往有结节性甲状腺肿手术史。镜下检查4例均为筛状/管状型腺样囊性癌，3例累及甲状腺组织，3例累及神经组织，未见淋巴结受累。免疫组织化学染色示4例P16、CD117、BCL2、P63、SMA均阳性，Ki67指数平均8%，TTF1和P53均阴性；4例中基底膜样物胶原Ⅳ阳性；组织化学染色示AB/PAS阳性。术后均接受总剂量为48~56 Gy的放疗，随访6~120个月，平均72.5个月，1例术后96个月复发，3例随访期间无复发及转移。结论　气管上段腺样囊性癌是罕见的原发于气管的低度恶性肿瘤，肿瘤生长缓慢，就诊时多数已侵及甲状腺组织，需要与原发于甲状腺的恶性肿瘤相鉴别，特别是在甲状腺穿刺及术中冰冻检查时。结合电子喉气管镜下表现、典型的形态学及免疫组织化学和组织化学染色有助于准确诊断。手术难以切除干净，术后放疗对延缓疾病复发有一定帮助。     

Development and monitoring of an integrated bioprocess for production of a potential malaria vaccine with Pichia pastoris

An engineered variant of the yeast Pichia pastoris was used to produce the potential malaria vaccine D1M1. This paper describes the implementation of an expanded bed adsorption chromatography step into a sequential cultivation process of the yeast in order to link protein expression, cell release, and product capture of the secreted protein in a fully automated plant. The process is operated with a semi-continuous strategy for an integrated production. Process improvements have been achieved using design of experiments. Resulting purities of product achieved up to 87% with recoveries of 51% in a single downstream operation. Furthermore, a multivariate analysis of historical batch data was used to develop a golden batch model for process monitoring.