Long-term sustained-released in situ gels of a water-insoluble drug amphotericin B for mycotic arthritis intra-articular administration: preparation,in vitro and in vivo evaluation

Amphotericin B (AMB) was often used in intra-articular injection administration for fungal arthritis, because it could often bring a satisfactory therapeutic efficacy and a minimum systemic toxic side effect. However, because of the multiple operations and the frequent injections, the compliance of the patients was bad. Therefore, to develop a long-term sustained-released preparation of AMB for mycotic arthritis intra-articular administration is of great significance. The purpose of present study was to develop a long-term sustained-released in situ gel of a water-insoluble drug AMB for mycotic arthritis intra-articular administration. Based on the evaluations of the in vitro properties of the formulations, the formulation containing 10% (w/w) ethanol, 15% (w/w) PG, 0.75% (w/w) HA, 5% (w/w) purified soybean oil, 0.03% (w/w) α-tocopherol, 15% (w/w) water and 55% (w/w) glyceryl monooleate was selected as a suitable intra-articular injectable in situ gel drug delivery system for water-insoluble drug AMB. Furthermore, the results of the in vivo study on rabbits showed that the selected formulation was a safe and effective long-term sustained-released intra-articular injectable AMB preparation. Therefore, the presented in situ AMB gel could reduce the frequency of the administration in the AMB treatment of fungal arthritis, and then would get a good patient compliance.     

REST API技术及在移动通信网络管理中的应用

介绍了目前最炙手可热的REST架构风格，该风格顺应Web2.0的兴起，完美的匹配了云计算时代来临的可扩展要求，在各种应用场景中都得到了充分的表现。根据其技术特点，分析了该风格的API在移动通信网络管理中的应用，从网管系统内部、网管系统之间以及网管系统与上层APP应用之间等多方面对是否适用于REST风格以及如何在合适的位置使用REST API进行了分析。     

新型钢丝圈清洁器的使用效果

为了解决钢丝圈挂花问题,阐述了LH001新型钢丝圈清洁器的特点和应用效果;通过试验说明使用新型钢丝圈清洁器断头率低,基本无挂花,纺纱效果好。指出:新型钢丝圈清洁器是普通钢丝圈清洁器的更新换代产品,值得推广。     

仙游抽水蓄能电站尾水系统充排水试验

为检查工程质量,查找输水系统可能存在的问题并消除隐患,保障电站安全运行,福建仙游抽水蓄能电站在投产发电前,要对输水发电系统进行充水试验与放空排水试验,在试验过程中监测输水系统的应力、应变与渗漏水情况。本文以尾水系统为例,介绍了试验所应具备的工程条件、工作程序及技术要求、试验成果分析和存在问题处理等。试验表明,仙游抽水蓄能电站尾水系统设计合理,施工质量优良,结构可靠,可供同类工程参考与借鉴。     

基于桥连接的词典学习方法的语义解析

现阶段的语义解析方法大部分都基于组合语义,这类方法的核心就是词典。词典是词汇的集合,词汇定义了自然语言句子中词语到知识库本体中谓词的映射。语义解析一直面临着词典中词汇覆盖度不够的问题。针对此问题,该文在现有工作的基础上,提出了基于桥连接的词典学习方法,该方法能够在训练中自动引入新的词汇并加以学习,为了进一步提高新学习到的词汇的准确度,该文设计了新的词语—二元谓词的特征模板,并使用基于投票机制的核心词典获取方法。该文在两个公开数据集(WebQuestions和Free917)上进行了对比实验,实验结果表明,该文方法能够学习到新的词汇,提高词汇的覆盖度,进而提升语义解析系统的性能,特别是召回率。     

基于Web的3D模型浏览与交互系统的研究与实现

设计了基于Web的3D模型浏览与交互系统，主要采用基于WebGL的第三方库Three.js来实现。该系统的建立主要包括场景的构建、场景的交互控制和模型的云存储。模型是场景构建的前提，用户可从外部导入所需模型或利用系统自带的简单模型进行模型的构建。场景交互技术主要包括模型的平移、旋转、缩放、拾取、剖切、3D动画模型的播放以及信息的显示等。模型的云存储是指用户可以通过登录账户将3D模型存储到服务器，日后需要时直接从服务器中加载即可。     

Decorative near-infrared transmission filters featuring high-efficiency and angular-insensitivity employing 1D photonic crystals

We present a new scheme for visibly-opaque but near-infrared-transmitting filters involving 7 layers based on one-dimensional ternary photonic crystals, with capabilities in reaching nearly 100% transmission efficiency in the near-infrared region. Different decorative reflection colors can be created by adding additional three layers while maintaining the near-infrared transmission performance. In addition, our proposed structural colors show great angular insensitivity up to ±60° for both transverse electric and transverse magnetic polarizations, which are highly desired in various fields. The facile strategy described here involves a simple deposition method for the fabrication, thereby having great potential in diverse applications such as image sensors, anti-counterfeit tag, and optical measurement systems.