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排序方式: 共有699条查询结果,搜索用时 24 毫秒
1.
The measurement of neonatal responses to painful stimuli remains a significant clinical problem. Although numerous measures have been evaluated, instruments that are valid, reliable, and clinically feasible are not yet available. The purpose of this paper is to critique the studies that have been done using biochemical, physiological, and behavioral measures to evaluate neonatal responses to painful stimuli. Specific issues regarding measurement in premature and critically ill neonates are emphasized. The intent of this review and critique of the literature is to stimulate additional research into the assessment of neonatal pain. 相似文献
2.
Auguste Commeyras Hlne Collet Laurent Boiteau Jacques Taillades Odile Vandenabeele‐Trambouze Herv Cottet Jean‐Philippe Biron Raphaël Plasson Louis Mion Olivier Lagrille Herv Martin Franck Selsis Michel Dobrijevic 《Polymer International》2002,51(7):661-665
Addressing the still open question of the prebiotic origin of sequential macromolecules (peptides, nucleic acids) on the primitive Earth, we describe a molecular engine (the primary pump), which works at ambient temperature and continuously generates, elongates and complexifies sequential peptides. This new scenario is based on a cyclic reaction sequence, whose keystep is the activation of amino acids into their N‐carboxyanhydrides (NCA) through nitrosation by NOx. This process could have taken place on tidal beaches; it requires a buffered ocean, emerged land and a nitrosating atmosphere. With the help of geochemical studies and computer simulations of atmosphere photochemistry, we show that the primitive Earth during the Hadean may have satisfied all these requirements. © 2001 Society of Chemical Industry. 相似文献
3.
A nonlinear regeneration pulsed oscillator driven by a monochromatic source has been built. Subharmonics of the resonance carrier/modulation are measured with an accuracy of 10-10 thanks to the use of a double beats measurement set-up. The multiscale analysis of frequency readings reveals a rich fine structure which is in agreement with the nonlinear topological approach of synchronized states. 相似文献
4.
A reported correlation between defect-initiated pulsed laser damage and local predamage scatter in multilayer infrared mirror coatings has been analyzed in detail. Examination of a much larger data base confirms the previous result on dielectric-enhanced reflectors with polished substrates over a wide range of energy densities above the damage onset. Scatter signals from individual undamaged defects were detected using a He-Ne scatter probe with a focal spot that nearly coincides with the 150-microm-diam (D1/e(2)) focal spot of the damage-probe beam. Subsequent damage frequency measurements (1-on-1) were made near normal or at 45 degrees incidence with 100-ns pulses at 2.7-microm wavelength. The correlation is characterized by an increase in damage frequency with increasing predamage scatter signal and by equivalence of the defect densities indicated by the two probes. Characteristics of the correlation are compared with a simple model based on focal spot intensity profiles. Conditions that limit correlation are discussed, including variable scatter from defects and background scatter from diamond-turned substrates. Results have implication for nondestructive defect detection and coating quality control. 相似文献
5.
Franck Paganelli Giovanna Mottola Julien Fromonot Marion Marlinge Pierre Deharo Rgis Guieu Jean Ruf 《International journal of molecular sciences》2021,22(4)
The influence of hyperhomocysteinemia (HHCy) on cardiovascular disease (CVD) remains unclear. HHCy is associated with inflammation and atherosclerosis, and it is an independent risk factor for CVD, stroke and myocardial infarction. However, homocysteine (HCy)-lowering therapy does not affect the inflammatory state of CVD patients, and it has little influence on cardiovascular risk. The HCy degradation product hydrogen sulfide (H2S) is a cardioprotector. Previous research proposed a positive role of H2S in the cardiovascular system, and we discuss some recent data suggesting that HHCy worsens CVD by increasing the production of H2S, which decreases the expression of adenosine A2A receptors on the surface of immune and cardiovascular cells to cause inflammation and ischemia, respectively. 相似文献
6.
Angkoon Phinyomark Franck Quaine Sylvie Charbonnier Christine Serviere Franck Tarpin-Bernard Yann Laurillau 《Computer methods and programs in biomedicine》2014
This paper demonstrates the utility of a differencing technique to transform surface EMG signals measured during both static and dynamic contractions such that they become more stationary. The technique was evaluated by three stationarity tests consisting of the variation of two statistical properties, i.e., mean and standard deviation, and the reverse arrangements test. As a result of the proposed technique, the first difference of EMG time series became more stationary compared to the original measured signal. Based on this finding, the performance of time-domain features extracted from raw and transformed EMG was investigated via an EMG classification problem (i.e., eight dynamic motions and four EMG channels) on data from 18 subjects. The results show that the classification accuracies of all features extracted from the transformed signals were higher than features extracted from the original signals for six different classifiers including quadratic discriminant analysis. On average, the proposed differencing technique improved classification accuracies by 2–8%. 相似文献
7.
A particle‐based moving interface method (PMIM) for modeling the large deformation of boundaries in soft matter systems 下载免费PDF全文
Louis Foucard Franck J. Vernerey 《International journal for numerical methods in engineering》2016,107(11):923-946
The mechanics of the interaction between a fluid and a soft interface undergoing large deformations appear in many places, such as in biological systems or industrial processes. We present an Eulerian approach that describes the mechanics of an interface and its interactions with a surrounding fluid via the so‐called Navier boundary condition. The interface is modeled as a curvilinear surface with arbitrary mechanical properties across which discontinuities in pressure and tangential fluid velocity can be accounted for using a modified version of the extended finite element method. The coupling between the interface and the fluid is enforced through the use of Lagrange multipliers. The tracking and evolution of the interface are then handled in a Lagrangian step with the grid‐based particle method. We show that this method is ideal to describe large membrane deformations and Navier boundary conditions on the interface with velocity/pressure discontinuities. The validity of the model is assessed by evaluating the numerical convergence for a axisymmetrical flow past a spherical capsule with various surface properties. We show the effect of slip length on the shear flow past a two‐dimensional capsule and simulate the compression of an elastic membrane lying on a viscous fluid substrate. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
8.
Sabeha Yala Mahfoud Boustta Olivier Gallet Mathilde Hindié Franck Carreiras Hamanou Benachour Djahida Sidane Hafit Khireddine 《Journal of materials science. Materials in medicine》2016,27(9):140
A novel synthetic method to synthesize hydroxyapatite/poly (D,L) lactic acid biocomposite is presented in this study by mixing only the precursors hydroxyapatite and (D,L) LA monomer without adding neither solvent nor catalyst. Three compositions were successfully synthesized with the weight ratios of 1/1, 1/3, and 3/5 (hydroxyapatite/(D,L) lactic acid), and the grafting efficiency of poly (D,L) lactic acid on hydroxyapatite surface reaches up to 84?%. Scanning electron microscopy and Fourier transform infrared spectroscopy showed that the hydroxyapatite particles were successfully incorporated into the poly (D,L) lactic acid polymer and X ray diffraction analysis showed that hydroxyapatite preserved its crystallinity after poly (D,L) lactic acid grafting. Differential scanning calorimetry shows that Tg of hydroxyapatite/poly (D,L) lactic acid composite is less than Tg of pure poly (D,L) lactic acid, which facilitates the shaping of the composite obtained. The addition of poly (D,L) lactic acid improves the adsorption properties of hydroxyapatite for fibronectin extracellular matrix protein. Furthermore, the presence of poly (D,L) lactic acid on hydroxyapatite surface coated with fibronectin enhanced pre-osteoblast STRO-1 adhesion and cell spreading. These results show the promising potential of hydroxyapatite/poly (D,L) lactic acid composite as a bone substitute material for orthopedic applications and bone tissue engineering. 相似文献
9.
Tristan Roussillon Hervé Piégay Isabelle Sivignon Laure Tougne Franck Lavigne 《Computers & Geosciences》2009,35(10):1992-2000
The shape of sedimentary particles is an important property, from which geographical hypotheses related to abrasion, distance of transport, river behavior, etc. can be formulated. In this paper, we use digital image analysis, especially discrete geometry, to automatically compute some shape parameters such as roundness, i.e. a measure of how much the corners and edges of a particle have been worn away.In contrast to previous work in which traditional digital images analysis techniques, such as Fourier transform, are used, we opted for a discrete geometry approach that allowed us to implement Wadell's original index, which is known to be more accurate, but more time consuming to implement in the field.Our implementation of Wadell's original index is highly correlated (92%) with the roundness classes of Krumbein's chart, used as a ground-truth. In addition, we show that other geometrical parameters, which are easier to compute, can be used to provide good approximations of roundness.We also used our shape parameters to study a set of pebbles digital images taken from the Progo basin river network (Indonesia). The results we obtained are in agreement with previous work and open new possibilities for geomorphologists thanks to automatic computation. 相似文献
10.
Validation of plant part measurements using a 3D reconstruction method suitable for high-throughput seedling phenotyping 总被引:2,自引:0,他引:2
Franck Golbach Gert Kootstra Sanja Damjanovic Gerwoud Otten Rick van de Zedde 《Machine Vision and Applications》2016,27(5):663-680
In plant phenotyping, there is a demand for high-throughput, non-destructive systems that can accurately analyse various plant traits by measuring features such as plant volume, leaf area, and stem length. Existing vision-based systems either focus on speed using 2D imaging, which is consequently inaccurate, or on accuracy using time-consuming 3D methods. In this paper, we present a computer-vision system for seedling phenotyping that combines best of both approaches by utilizing a fast three-dimensional (3D) reconstruction method. We developed image processing methods for the identification and segmentation of plant organs (stem and leaf) from the 3D plant model. Various measurements of plant features such as plant volume, leaf area, and stem length are estimated based on these plant segments. We evaluate the accuracy of our system by comparing the measurements of our methods with ground truth measurements obtained destructively by hand. The results indicate that the proposed system is very promising. 相似文献