A Case Report of Germline Compound Heterozygous Mutations in the BRCA1 Gene of an Ovarian and Breast Cancer Patient

The germline carrier of the BRCA1 pathogenic mutation has been well proven to confer an increased risk of breast and ovarian cancer. Despite BRCA1 biallelic pathogenic mutations being extremely rare, they have been reported to be embryonically lethal or to cause Fanconi anemia (FA). Here we describe a patient who was a 48-year-old female identified with biallelic pathogenic mutations of the BRCA1 gene, with no or very subtle FA-features. She was diagnosed with ovarian cancer and breast cancer at the ages of 43 and 44 and had a strong family history of breast and gynecological cancers.     

基于ERNIE-BiGRU模型的摘要语步自动识别研究

学术文献的摘要是对文献主要内容的浓缩,摘要不同部分的语步具有不同的信息,语步的自动识别和抽取对于学术摘要的后续研究有着重要的应用价值,而目前语步识别的研究相对较少,并且相关算法的效果还需要提高。针对上述问题,该文提出了一种基于ERNIE-BiGRU模型的语步识别算法。该算法首先结合中文句法分析理论提出基于句法依存关系的多语步结构拆分法,对学术文献摘要多语步结构进行自动拆分,获得多个单语步结构;然后构建用于训练的单语步结构语料库,并利用知识增强语义表示预训练模型,训练出句子级词向量;最后将训练出的单语步结构词向量信息输入双向门限循环单元(BiGRU)进行摘要语步自动化识别,取得了良好的效果。实验结果表明,该算法具有较好的鲁棒性和较高的识别精度,在结构化和非结构化摘要上的识别准确率分别达到了96.57%和93.75%。     

基于人脸卡口数据的行人共现关系图谱构建

随着人脸识别技术的不断进步以及人脸卡口的大范围且密集的部署, 本文针对团伙犯罪案件侦察这一应用场景, 对人脸卡口数据进行深入挖掘, 探究其中行人间的共现关系, 获取所关注的嫌疑人的现实社交网络, 锁定团伙其余人员. 经过实验比对和论证, 本文使用Chinese Whispers聚类算法对行人节点进行识别, 通过Faiss加速邻接边的构建, 加速图的初始化步骤, 解决其聚类效率低下的问题. 在此基础上, 使用共现频次和Apriori算法中的置信度挖掘行人间的共现关系, 构建行人共现关系图谱.     

Sustainable phenolic thermosets coatings derived from urushiol

The over-exploitation of finite fossil resources and/or the increased environmental and sustainable awareness inspire scientists and technologists to search for inexpensive alternatives from renewable chemicals. Phenol formaldehyde (PF) resins, the oldest type of synthetic polymers with good mechanical properties and heat resistance, are widely used in the production of coatings, laminates, molding compositions, and glues. Here, biobased urushiol-derived PF resins were synthesized from the alkali-catalyzed reaction between urushiol and formaldehyde. The chemical compositions and molecular structures of resole resins were characterized by carbon-13 nuclear magnetic resonance and Fourier transform infrared spectroscopy, and their curing behaviors were studied by differential scanning calorimetry. The as-prepared urushiol-derived resole resins had methylol (Ph−CH₂OH), ortho- and para-hemiformal groups (Ph−CH₂OCH₂OH), and the para−para/ortho−para/ortho−ortho links of methylene groups (Ph−CH₂−Ph), whereas the resole resins had low curing temperatures at about 100–113°C. Additionally, given the long side alkyl group moiety on the aromatic rings of urushiol, the films of cured urushiol-derived resole resins had low glass transition temperatures of 132 ± 2°C. Furthermore, the as-prepared urushiol-derived coatings exhibited excellent physical and mechanical properties.     

Combination of dynamic features with a new mask to optimize neural network speech enhancement

Concerning the problem that the Neural Network speech enhancement algorithm cannot fully represent the nonlinear structure of speech due to feature selection,which leads to speech distortion.This paper proposes the combination of dynamic features with a new mask to optimize neural network speech enhancement.First,three features of noisy speech are extracted and spliced to obtain static features.Then,the first and second difference derivatives are obtained to capture the instantaneous signals of speech and fuse them into dynamic features.The combination of dynamic and static features completes internal complementarity of features and reduced speech distortion.Second,in order to enhance the intelligibility and clarity of speech at the same time,an adaptive mask is proposed,which can adjust the energy ratio of speech and noise as well as the ratio of the traditional mask and the square root mask.The Gammatone channel weight is used to modify the mask value in each channel to simulate the human auditory system and further improve the speech intelligibility.Finally,the simulation of multiple voices under different noise backgrounds shows that compared with different literature algorithms,the algorithm has a higher SNR,subjective speech quality and short-term objective intelligibility,which verifies the effectiveness of the algorithm.     

中医药膳与特膳食品产业融合发展思辨

中医药膳与特膳食品一样,均能为特定人群系统定量地提供特殊或针对性的生理物质与营养成分,从而改善特定人群的营养基础代谢,减少不必要的代谢负担。文章提出在健康中国战略背景下加强特膳食品与中医药膳产业融合发展的必要性及发展的瓶颈,并指出两者融合发展的有效路径。     

概念辨析：建筑评论的思辨实践

建筑评论是一项针对具体对象,将目之所及的事物背后不可视的背景、思想、价值判断、驱动力等,转化为可以言说、可以讨论、具有建筑学和文化社会意义的思辨性活动。[1]这项活动的基础工作之一是概念的辨析与运用。因此,在东南大学建筑学院开设的"建筑评论课",通过课程主题的组织,在帮助学生建立多维批评视野的同时,以概念辨析为切入点,通过基于精读、研究的写作训练,实现思辨性思维的培养、学术素养和写作的培训,以及对建筑评论和中国现当代建筑话语的理解。     

Indoor solid fuel use for heating and cooking with blood pressure and hypertension: A cross-sectional study among middle-aged and older adults in China

A cross-sectional study was conducted to investigate the impact of solid fuel use for heating and cooking on blood pressure (BP) and hypertension, using data from the China Health and Retirement Longitudinal Study (CHARLS). The primary fuels used for indoor heating and cooking were collected by questionnaires, respectively. Hypertension was defined based on self-report of physician's diagnosis, and/or measured BP, and/or anti-hypertensive medication use. Multivariate logistic regression models were constructed to assess the associations. Among 10 450 eligible participants, 68.2% and 57.2% used indoor solid fuel for heating and cooking, respectively. Compared with none/clean fuel users, solid fuel for heating was associated with elevated BP (adjusted β: 2.02, 95% CI: 1.04–3.01 for systolic BP; adjusted β: 1.36, 95% CI: 0.78–1.94 for diastolic BP) and increased risk of hypertension (adjusted odds ratio: 1.15, 95% CI: 1.03–1.29). The impact of indoor solid fuel for heating on BP was more evident in rural and north residents, and hypertensive patients. We did not detect any significant associations between solid fuel use for cooking and BP/hypertension. Indoor solid fuel use is prevalent in China, especially in the rural areas. Its negative impact on BP suggested that modernization of household fuel use may help to reduce the burden of hypertension in China.     

Reviews of clean coal conversion technology in China:Situations & challenges

It is important to develop the advanced coal to chemicals industry (ACCI) against a backdrop of coal-based energy structures,excessive imported oil and natural gas,and strict environmental con-straints in China.In this study,the technology and industry of China's ACCI are reviewed to explain the effect of using coal to replace oil and natural gas,and the corresponding resource and environmental burdens that this will create.Development trends in technology and industry are also proposed to explore future scenarios.The review shows that although excellent progress has been made on an indus-trial scale,demonstrative level,and in terms of technology and equipment,the lack of strategic under-standing,severe external constraints,partly underdeveloped technologies,and weak foundations must be immediately addressed.Therefore,it is necessary to clarify the importance that the ACCI has on the energy revolution and energy system.Based on technological innovation,a variety of external factors should be considered as a whole with emphasis on filling the knowledge gap of theoretical foundations and industry standards to support high-quality development for ACCI.