面向连续查询的敏感语义位置隐私保护方案

针对连续查询位置服务中构造匿名区域未考虑语义位置信息导致敏感隐私泄露问题，通过设计[(K,θ)]-隐私模型，提出一种路网环境下面向连续查询的敏感语义位置隐私保护方案。该方案利用Voronoi图将城市路网预先划分为独立的Voronoi单元，依据用户的移动路径和移动速度，选择具有相似特性的其他[K-1]个用户，构建匿名用户集；利用匿名用户集用户设定的敏感语义位置类型和语义安全阈值，以及用户所处语义位置的Voronoi单元，构建满足[(K,θ)]-隐私模型的语义安全匿名区域，可以同时防止连续查询追踪攻击和语义推断攻击。实验结果表明，与SCPA算法相比，该方案在隐私保护程度上提升约15%，系统开销上降低约20%。     

Microwave dielectric properties of SrLa[Ga1−x(Mg0.5Ti0.5)x]O4 and SrLa[Ga1−x(Zn0.5Ti0.5)x]O4 (x = 0.2-0.8) ceramics

SrLa[Ga_1−x(R_0.5Ti_0.5)_x]O₄ (R = Mg, Zn) ceramics were prepared by a standard solid state sintering method. The single-phase ceramics with K₂NiF₄-type layered perovskite structure and I4/mmm space group were obtained, indicating that SrLa(R_0.5Ti_0.5) and SrLaGaO₄ can form the unlimited solid solutions. With increasing x for R = Mg and Zn, ε_r increases monotonously, the Qf value first increases and then decreases, while τ_f increases from a negative to a positive value. The optimized microwave dielectric properties were obtained as following: ε_r = 23.3, Qf = 89 400 GHz, τ_f = −0.8 ppm/°C for SrLa[Ga_0.6(Mg_0.5Ti_0.5)_0.4]O₄ and ε_r = 23.3, Qf = 76 200 GHz, τ_f = 0.2 ppm/°C for SrLa[Ga_0.7(Zn_0.5Ti_0.5)_0.3]O₄, indicating that the present solid solution ceramics are the promising candidates as microwave resonator materials for the telecommunication applications.     

粒子群属性聚类的位置隐私保护

针对基于位置服务中连续查询情况下，用户自身属性信息很容易被攻击者获取，并通过关联获得用户位置隐私的情况，提出了一种利用粒子群聚类加速相似属性用户寻找，并由相似属性匿名实现用户位置泛化的隐私保护方法。该方法利用位置隐私保护中常用的可信中心服务器，通过对发送到中心服务器中的查询信息进行粒子群属性聚类，在聚类的过程中加速相似属性用户的寻找过程，由相似属性用户完成位置泛化，以此实现位置隐私保护。实验结果证明，这种基于粒子群属性聚类的隐私保护方法具有高于同类算法的隐私保护能力，以及更快的计算处理速度。     

The dispersed SiO2 microspheres supported Ru catalyst with enhanced activity for ammonia decomposition

Ru nanoparticles supported on SiO₂ microspheres (Ru/SiO₂-GUS) were prepared by the glucose-urea-metallic salt method and applied in the decomposition of ammonia. In the glucose-urea-metallic salt method, glucose as the carbon template plays a significant role in the formation of diffusion-beneficial structural properties of Ru/SiO₂-GUS, and also induceds the modification of the electronic state of Ru. Ru/SiO₂-GUS exhibited higher catalytic activity compared with the catalyst prepared with the impregnation method. The catalytic performance of Ru/SiO₂-GUS was further enhanced with the addition of either K or Cs——the addition order and amount strongly affecting the catalytic performance. When the ratio of K/Cs to Ru is 2, the alkali metal (KOH/CsOH) solution is added in the homogeneous solution of glucose, urea, RuCl₃ and the colloidal silica, the promotion effect of K/Cs is the strongest, particularly under lower reaction temperatures. However, the promotion effects of K and Cs are different as reveled by the combined results of H₂-TPR, XPS and NH₃-TPSR. More NH₃ can be absorbed on K–Ru/SiO₂-GUS and the electron density of Ru decreased. By contrast, more metallic Ru formed on Cs–Ru/SiO₂-GUS, facilitating N₂ recombination.     

Rhombellation: a builder for multi-shell clusters

Rhombellanes are mathematical structures, proposed by us in 2017; they may appear both in periodic crystals or in finite structures. The simplest rhombellane is rbl.5 or K_2.3, the complete bipartite graph. In this paper, rhombellation operation is iteratively applied on three classes of structures: cube, tori and cubic pcu-network, respectively. The structural topological parameters are detailed.     

Interaction of IL-22/IL-22R1 promotes cell proliferation and suppresses apoptosis of colorectal cancer via phosphorylation of STAT3

Interleukin-22 (IL-22) is a member of IL-10 cytokine family which is expressed in activated T cells predominantly and in activated natural killer cells at lower levels. Previous studies have demonstrated the link between elevated levels of IL-22 and disease severity of psoriasis, Crohn’s disease, rheumatoid arthritis and interstitial lung diseases. However, the function of IL-22 in the development and progression of colorectal cancer (CRC) remains elusive. In this study, we first evaluated the IL-22/IL-22R1 level in CRC patients, and found that tumor tissues have more active expression of IL-22 and IL-22R1 than normal tissues, presenting correlation with the degree of differentiation of tumor tissues. Subsequently, Caspase and cell viability assays were performed on SW-480 cell line which expresses high level of IL-22R1 to examine if the supplementation of IL-22 has an impact on apoptosis and proliferation. In comparison with treatment of 5-FU, supplementation of IL-22 promoted cell proliferation and ameliorated apoptosis. To unveil signal transduction upon activation of IL-22R, we examined the phosphorylation of STAT3 in SW-480 cell line following supplementation of IL-22. The treatment of IL-22 also increased the level of p-Akt, an essential component in PI3K/Akt pathway. Although the link between STAT3 phosphorylation and PI3K/ Akt activation remains to be explored, our study revealed the mechanism underlying the effects of IL-22R activation on apoptosis as well as tumor differentiation, indicating the prognostic value of IL-22/IL-22R.     

PI3K/AKT/GSK3β信号通路参与腺苷A1R介导异丙酚对缺血再灌注损伤大鼠的脑保护作用

目的：探讨PI3K/AKT/GSK-3β信号通路参与异丙酚对缺血再灌注损伤大鼠的脑保护作用及机制。方法：健康雄性SD大鼠72只，所有大鼠参照Zea Longa法建立局灶性脑缺血再灌注损伤的模型。随机分成6组（n=12），A-假手术组，B-模型组（MCAO），C-异丙酚组，D-异丙酚+腺苷A1R拮抗剂组（DPCPX），E-异丙酚组+PI3K特异性抑制剂（LY294002），F-异丙酚+GSK-3β抑制剂组（SB216763），观察大鼠术后24 h神经功能评分情况；LDF监测插栓前后脑血流变化；采用TTC染色法检测各组大鼠的脑梗死体积；用HE染色方法观察大鼠脑组织形态学改变；免疫组织化学法检测Bcl-2阳性细胞表达；采用TUNEL检测各组大脑脑皮质缺血周围神经元凋亡细胞的百分率。结果：与A组比较，B、C、D、E及F组大鼠行为学、脑梗死体积、细胞凋亡率、Bcl-2蛋白表达量均增加（P<0.05）；与C组比较，B、D、E组大鼠行为学评分，脑梗死体积及细胞凋亡率均明显增加，Bcl-2蛋白表达量均明显减少（P<0.01），F组Bcl-2蛋白表达量却增加，细胞凋亡率降低（P<0.05），行为学评分减少、梗死体积减少（P<0.05）。 结论：腺苷A1R介导的异丙酚对缺血再灌注损伤大鼠的神经保护作用可能与PI3K/AKT/GSK-3β信号转导通路有关。     

A longitudinal observational study of the dynamics of Mycoplasma bovis antibodies in naturally exposed and diseased dairy cows

Mycoplasma bovis is an important pathogen causing disease and substantial economic losses in cattle. However, knowledge of the dynamics of antibody responses in individual cows in the face of an outbreak is currently extremely limited. The use of commercial antibody tests to support clinical decision-making and for surveillance purposes is therefore challenging. Our objective was to describe the dynamics of M. bovis antibody responses in 4 Danish dairy herds experiencing an acute outbreak of M. bovis-associated disease, and to compare the antibody dynamics between dairy cows with different disease manifestations. A total of 120 cows were examined using a standardized clinical protocol and categorized into 4 disease groups: “mastitis,” “systemic,” “nonspecific,” and “none.” Paired blood and milk samples were collected and tested using a commercial M. bovis antibody–detecting ELISA. Plots of raw data and generalized additive mixed models with cow and herd as random effects were used to describe serum and milk antibody dynamics relative to the estimated time of onset of clinical disease. Cows with mastitis had high optical density measurement (ODC%) of antibodies in both milk and serum at disease onset. The estimated mean ODC% in milk was below the manufacturer's cut-off for the other groups for the entire study period. The estimated mean serum ODC% in the “systemic” group was high at onset of disease and stayed above the cut-off until 65 d after disease onset. However, the lower 95% confidence interval (CI) for the mean ODC% was only above the manufacturer's cut-off between 7 and 17 d after onset of disease. The CI of the “systemic” and “none” groups did not overlap at any time between the day of disease onset and 65 d after disease onset, and the estimated mean ODC% for both the “nonspecific” and “none” groups were generally below the cut-off for the majority of the study period. In conclusion, the serum antibody responses were highly dynamic and showed a high level of variation between individual cows. This strongly suggests that serology is unlikely to be useful for individual diagnosis of M. bovis-associated disease in dairy cows. However, it might still be useful for herd- or group-level diagnosis. Antibodies in milk were only increased in cows with M. bovis mastitis, indicating that milk antibody measurements only have diagnostic utility for cows with mastitis.     

指甲花叶色素对涤纶织物染色及防紫外线整理

文中研究了指甲花叶色素对涤纶织物染色及防紫外线整理,首先探讨了涤纶织物高温高压指甲花叶色素直接染色的较优工艺,并以硫酸铝钾和单宁酸作为媒染剂对织物进行后媒染色,探讨了媒染剂媒染对染色性能及防紫外线效果的影响。结果表明,指甲花色素对涤纶织物高温高压直接染色工艺较优条件为:染色温度125℃、染色时间60 min、染液浓度30 g/L和pH值=3,染色后织物耐皂洗色牢度和耐摩擦色牢度满足穿着要求,且具有一定的防紫外线性能;硫酸铝钾和单宁酸作为媒染剂对涤纶织物后媒染色有利于提升指甲花叶色素上染涤纶织物的效果及防紫外线能力。