KL油田明化镇组富砂型沉积储层特征研究

KL油田的主要含油层系为新近系明化镇组,砂岩含量高,储层发育,叠置连片分布,表现为"富砂"的沉积特征,地震资料品质不支持进行常规的单砂体描述。基于岩心、分析化验、测井曲线等资料,对KL油田明化镇组储层岩性特征、孔隙特征及物性特征进行分析,认为明化镇组储层为浅水三角洲沉积,储层具有特高孔、特高渗的特征。根据地震相特征,并结合沉积相和测井相,按储层发育特征将研究区储层分为三类,并提取振幅属性,刻画出砂体边界,对储量进行了重新认识。研究结果对油田开发方案的编制以及后期的生产调整具有重要意义。     

Exploring the Role of IL-36 Cytokines as a New Target in Psoriatic Disease

Unmet needs in the treatment of psoriasis call for novel therapeutic strategies. Pustular psoriasis and psoriatic arthritis often represent a therapeutic challenge. Focus on IL-36 cytokines offers an interesting approach, as the IL-36 axis has been appointed a critical driver of the autoinflammatory responses involved in pustular psoriasis. Two IL-36R blocking antibodies, imsidolimab and spesolimab, are currently undergoing phase II and III clinical trials, with promising results.     

DH36钢中的动态应变时效特性

利用准静态试验机和Hopkinson压杆装置对DH36钢在不同应变率和不同温度下的塑性流动应力进行试验研究。结果表明:预应变温度对DH36钢的力学性能有显著的影响;在动态应变时效温度区,出现时效强化所需时间较短;DH36钢塑性流动中出现的动态应变时效是由于温度和变形达到一定程度时,曾在林位错周围形成的溶质气团会沿着聚合的林位错通过管道扩散到运动位错处,并在位错附近形成溶质气团连续对位错形成拖曳,阻碍了位错运动,同时,在高温出现珠光体片间距减小,相界面增多,对位错运动的阻碍增大,因而也会导致塑性流动阻力提高。     

中海油减三线馏分油生产橡胶油工艺研究

中海油绥中36-1减三线馏分油,芳烃、硫、氮含量高,粘度大,是典型的环烷基油。通过一段溶剂精制工艺可生产CA为10.0%的环保橡胶油,产品性质良好,环保性能佳,达到国内同类产品水平。通过加氢处理-临氢降凝-补充后精制的三段高压加氢工艺可生产性质优良的SBS橡胶填充油。主产品收率较高,可达83.9%,CN值高达53.9%,芳烃含量极低,产品性质达到国内先进水平,且部分性质优于同类产品,应有良好的使用性能。     

Synthesis of Invar 36 type alloys from elemental and prealloyed powders by mechanical alloying

Invar 36 (Fe₆₄Ni₃₆) nanocrystalline powders were successfully obtained by the mechanical alloying process. The mechanically alloyed Invar 36 powders were obtained from both, Fe–Ni elemental and Fe–Ni₃Fe prealloyed powders. XRD, DSC and magnetic measurements were used to characterise the Invar 36 powders. The lattice parameter evolution versus temperature of Invar 36 powders was investigated by in-situ high-temperature X-ray diffraction (HT-XRD). For both, Invar 36 (Fe, Ni) and Invar 36 (Fe, Ni₃Fe) powders, the lattice parameter values are constant up to about 350°C. The magnetic measurement also indicated that the Invar 36-type alloys are formed after 16?h of milling.     

TRPV1 Responses in the Cerebellum Lobules VI,VII, VIII Using Electroacupuncture Treatment for Chronic Pain and Depression Comorbidity in a Murine Model

Depression is a prominent complex psychiatric disorder, usually complicated through expression of comorbid conditions, with chronic pain being among the most prevalent. This comorbidity is consistently associated with a poor prognosis and has been shown to negatively impact patient outcomes. With a global rise in this condition presenting itself, the importance of discovering long-term, effective, and affordable treatments is crucial. Electroacupuncture has demonstrated renowned success in its use for the treatment of pain and is a widely recognized therapy in clinical practice for the treatment of various psychosomatic disorders, most notably depression. Our study aimed to investigate the effects and mechanisms of Acid-Saline (AS) inducing states of chronic pain and depression comorbidity in the cerebellum, using the ST36 acupoint as the therapeutic intervention. Furthermore, the role of TRPV1 was relatedly explored through the use of TRPV1^−/− mice (KO). The results indicated significant differences in the four behavioral tests used to characterize pain and depression states in mice. The AS and AS + SHAM group showed significant differences when compared to the Control and AS + EA groups in the von Frey and Hargreaves’s tests, as well as the Open-Field and Forced Swimming tests. This evidence was further substantiated in the protein levels observed in immunoblotting, with significant differences between the AS and AS + SHAM groups when compared to the AS + EA and AS + KO groups being identified. In addition, immunofluorescence visibly served to corroborate the quantitative outcomes. Conclusively these findings suggest that AS-induced chronic pain and depression comorbidity elicits changes in the cerebellum lobules VI, VII, VIII, which are ameliorated through the use of EA at ST36 via its action on TRPV1 and related molecular pathways. The action of TRPV1 is not singular in CPDC, which would suggest other potential targets such as acid-sensing ion channel subtype 3 (ASIC3) or voltage-gated sodium channels (Navs) that could be explored in future studies.     

壳寡糖对体外诱导的非酒精性脂肪肝细胞模型的降脂机理研究

为探讨壳寡糖在体外对肝脂质积累的抑制效果及潜在作用机制,选用油酸钠诱导HepG2细胞建立非酒精性脂肪肝细胞模型,通过油红O染色及各试剂盒检测胞内总脂质积累、甘油三酯、总胆固醇、高低密度脂蛋白胆固醇及游离脂肪酸的含量,实时定量PCR及western blot检测细胞内脂代谢相关基因和蛋白的表达。结果发现,4.0mg/mL的壳寡糖对肝脂质蓄积具有明显的抑制作用,并降低了二酰基甘油酰基转移酶2(DGAT2)、肝X受体α(LXRα)、过氧化物酶体增殖物激活受体-γ(PPARγ)、孕烯醇酮X受体(PXR)和分化簇36(CD36)的mRNA水平和蛋白水平的表达。研究结果表明,壳寡糖可以通过调节脂肪酸吸收和甘油三酯合成通路从而降低非酒精性脂肪肝细胞模型中的脂质积累。希望本研究能够为利用壳寡糖开发具有降脂护肝功能的膳食补充剂提供理论参考。     

基于经验分布和KL散度的协同过滤推荐质量评价研究

提出了一种基于经验分布和KL散度的协同过滤推荐质量评价方法RQE-EDKL（recommendation quality evaluation based on empirical distribution and KL divergence）。RQE-EDKL首先利用历史用户—商品数据生成不同商品数量下的商品历史使用概率分布；然后，利用该分布与各个协同过滤推荐方法得到的用户商品使用概率进行比较，计算其KL散度；最后，将KL散度最小的推荐结果视为最佳推荐结果并推送给用户。在TalkingData数据集上的实验结果表明，RQE-EDKL评价方法能够有效地在不同的推荐结果中选择更为切合用户真实需求的推荐结果，从而提高了协同过滤推荐的质量。     

信息检索结果隐式多样化排序方法研究

针对信息检索隐式多样化算法展开研究。介绍了检索结果重排序中的最大边际相关度(MMR)算法、相对熵(KL)算法、现代投资组合理论(MPT)3个隐式多样化算法，采用此3个算法对所选的已排序的文档数据集进行重排，通过对排序结果进行评价来对比三者的性能。得出隐式多样化方法中当相关性和多样性以一定比例的线性组合时，会使最终的检索结果在一些评价指标上相对于原始结果有所提高。