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1.
边界识别是位场数据解释中一项重要任务,可用于资源探测等领域,是目前研究的热点问题之一。对于深部异常体目标,采用传统的边界识别方法易出现模糊、发散、变形等问题,而改进的方法大多采用高阶导数,虽然能够很好地识别出深部异常体边界,但是计算复杂,易受噪声干扰。为了改善以上问题,提出了一种稳定的快速边界识别方法,仅利用符号函数和重磁垂直导数数据,即可均衡识别不同深度的目标,且避免了高阶导数的计算。通过理论模型的实验与对比,验证了方法的便捷性、有效性、抗斜磁化能力以及抗噪能力。同时,应用实测数据验证了方法在复杂重磁环境下,能够准确清晰地分辨出异常体,可节约相关研究人员的大量时间与精力,具有很好地应用前景。  相似文献   
2.
This study evaluated the direct effect of a phytochemical, hesperidin, on pre-osteoblast cell function as well as osteogenesis and collagen matrix quality, as there is little known about hesperidin’s influence in mineralized tissue formation and regeneration. Hesperidin was added to a culture of MC3T3-E1 cells at various concentrations. Cell proliferation, viability, osteogenic gene expression and deposited collagen matrix analyses were performed. Treatment with hesperidin showed significant upregulation of osteogenic markers, particularly with lower doses. Mature and compact collagen fibrils in hesperidin-treated cultures were observed by picrosirius red staining (PSR), although a thinner matrix layer was present for the higher dose of hesperidin compared to osteogenic media alone. Fourier-transform infrared spectroscopy indicated a better mineral-to-matrix ratio and matrix distribution in cultures exposed to hesperidin and confirmed less collagen deposited with the 100-µM dose of hesperidin. In vivo, hesperidin combined with a suboptimal dose of bone morphogenetic protein 2 (BMP2) (dose unable to promote healing of a rat mandible critical-sized bone defect) in a collagenous scaffold promoted a well-controlled (not ectopic) pattern of bone formation as compared to a large dose of BMP2 (previously defined as optimal in healing the critical-sized defect, although of ectopic nature). PSR staining of newly formed bone demonstrated that hesperidin can promote maturation of bone organic matrix. Our findings show, for the first time, that hesperidin has a modulatory role in mineralized tissue formation via not only osteoblast cell differentiation but also matrix organization and matrix-to-mineral ratio and could be a potential adjunct in regenerative bone therapies.  相似文献   
3.
Chameleonic properties, i. e., the capacity of a molecule to hide polarity in non-polar environments and expose it in water, help achieving sufficient permeability and solubility for drug molecules with high MW. We present models of experimental measures of polarity for a set of 24 FDA approved drugs (MW 405-1113) and one PROTAC (MW 1034). Conformational ensembles in aqueous and non-polar environments were generated using molecular dynamics. A linear regression model that predicts chromatographic apparent polarity (EPSA) with a mean unsigned error of 10 Å2 was derived based on separate terms for donor, acceptor, and total molecular SASA. A good correlation (R2=0.92) with an experimental measure of hydrogen bond donor potential, Δlog Poct-tol, was found for the mean hydrogen bond donor SASA of the conformational ensemble scaled with Abraham's A hydrogen bond acidity. Two quantitative measures of chameleonic behaviour, the chameleonic efficiency indices, are introduced. We envision that the methods presented herein will be useful to triage designed molecules and prioritize those with the best chance of achieving acceptable permeability and solubility.  相似文献   
4.
某厂在锯切20MnCr5圆棒过程中锯条容易断裂,采用光学显微镜(OM)和扫描电子显微镜(SEM)等观察分析手段,对锯条容易断裂的原因进行分析。分析结果表明:锯条断裂的原因为加工20MnCr5过程中粘刀崩齿。针对此类加工缺陷,提出了相应的改进措施。  相似文献   
5.
In the past decades, pyrochlores, such as Gd2Zr2O7, have demonstrated great potential to immobilize nuclear wastes such as Pu, which results in the production of Pu2Zr2O7. Due to the high radioactivity of Pu, it is difficult to investigate the radiation response behavior of Pu2Zr2O7 and its physical properties of the damaged state experimentally. Consequently, few related data have been reported in the literature thus far. In this study, first-principles calculations have been carried out to investigate the defect formation and its effect on the thermodynamic properties of Pu2Zr2O7. It reveals that PuZr antisite and O8a interstitial defects are very easy to form in Pu2Zr2O7. In particular, the O8a interstitial defect can be formed spontaneously, while it is mechanically unstable. When vacancy, interstitial or antisite defects are formed in Pu2Zr2O7, and the elastic moduli and Debye temperature are decreased. Besides, better ductility is resulted. As compared with other zirconate pyrochlores, such as Gd2Zr2O7, the Pu2Zr2O7 is suggested to be less resistant to radiation-induced amorphization. This study demonstrates that the created defects due to self-radiation from actinide decay have remarkable influences on the thermophysical properties of Pu2Zr2O7.  相似文献   
6.
Well-sintered CaO granules with hydration resistance are very important for the manufacturing and application of CaO-containing refractories. CaO granules with sol-processed metal oxide protective layers were prepared by granulation and surface treatment. The obtained results indicated that the usage of nano sol greatly improved the hydration resistance of CaO granules, especially when the CaO granules were treated by alumina sol. The promoting effect of nano sols in the sintering processes improved the density of CaO granules. Nanoparticles reacted with lime at lower temperature and a new phase was formed uniformly in the treated layer, which promoted densification of the treated layer. The grain size of CaO granules in the treated layer was increased obviously with the promotion of sintering. Moreover, nanoparticles were favorable for the formation of direct bonding between CaO grains by decreasing the dihedral angle.  相似文献   
7.
新疆准噶尔盆地南缘高探1井于白垩系清水河组测试获日产原油1213 m3/d、天然气32.17×104m3,创整个盆地单井日产量最高纪录,充分证实了南缘油气勘探潜力巨大[1]。为此,2019年,新疆油田在南缘共部署了875 km2三维地震采集项目,采用了井震联合采集技术、井炮源驱动技术、有线仪器+无线节点+有线连续采集技术、宽频单点接收技术、光纤表层调查技术等,高效、高质量完成了野外地震采集,地震资料品质得到了较好的提高,初步形成了适合南缘山前带的地震采集技术,为南缘山前带油气勘探和和下一步增储建产储备了相关的配套技术,该技术也可为国内其它探区山前带地震采集提供借鉴。  相似文献   
8.
晋城寺河井区煤矿采空区煤层气地面抽采关键技术研究   总被引:2,自引:0,他引:2  
随着煤层气勘探的不断深入,煤矿采空区煤层气已成为煤矿区煤层气重要资源之一。基于晋城矿区寺河井区煤矿采空区分布特征,通过地质分析、采空区煤层气成分、浓度试验和资源量模型计算等方法系统研究了煤矿采空区煤层气资源条件及地面抽采关键技术,揭示了采空区煤层气赋存规律,给出了不同赋存状态下煤层气资源量计算模型和方法,探索了煤矿采空区煤层气地面抽采关键技术。研究表明,煤矿采空区煤层气来源于煤柱及残留煤层、邻近未采煤层和围岩中的游离气和吸附气。根据吸附气和游离气资源量计算模型计算寺河井区煤层气总资源为213.016×108m3,其中游离气资源为0.102×108m3,吸附气资源为212.914×108m3。采煤方法和采空区密闭性对采空区煤层气的来源和富集程度有重要影响。针对采空区上部岩体裂隙发育特征,将采空区煤层气抽采井身结构由二开优化为三开结构,实现了二开固井封闭断裂带上部含水层,三开下入割缝套管护壁,有效解决了采空区上部含水层涌水对钻井井身稳定性影响及抽采效果等问题。在此基础上,研发了潜孔锤+压缩空气(氮气)钻井工艺,用氮气取代空气作为循环介质,形成了安全揭露含气断裂带钻井工艺技术,为采空区煤层气安全抽采探索了有效途径。  相似文献   
9.
采用响应面分析法的4因子中心组合实验设计(Central composite experimental design,CCD)优化了库车小白杏混菌(植物乳杆菌和罗伊氏乳杆菌)乳酸发酵工艺,并采用Logistic方程建立乳酸菌生长和超氧化物歧化酶(Superoxide dismutase,SOD)活性的动力学模型。结果表明,最佳发酵工艺为:温度为37.0 ℃,植物乳杆菌:罗伊氏乳杆菌配比为2.6:1,接种量为5.0%,发酵时间为30 h。在此条件下,杏汁中的SOD活性为309.60 U/g,感官评分为54.18分;动力学模型的预测值与实验值的拟合度分别为0.9970、0.9913,说明拟合曲线与乳酸菌生长量和SOD活性的实验数据有很高的相关性,能很好地模拟小白杏乳酸发酵过程的动力学特性。  相似文献   
10.
以黑木耳(Auricularia auricula-judae)粉末为材料,研究了超声微波联用辅助提取黑木耳黑色素的方法。通过单因素实验考察黑木耳干粉粉碎粒度、超声功率、微波功率和超声微波联用时间对提取效果的影响,并采用响应面法优化工艺条件。通过与传统溶剂提取法及超声辅助提取法进行比较,结合扫描电镜(Scanning electron microscope)观察不同提取方法对于黑木耳干粉组织结构的破坏程度,以此验证超声微波联用辅助提取黑木耳黑色素的优势。结果表明:木耳黑色素的最佳提取工艺条件是:超声功率398 W、微波功率392 W、联合作用时间31 min。此条件下黑木耳黑色素吸光度为0.984,粗黑色素得率达到9.10%,相较传统溶剂法提取法(7.20%)、超声辅助提取法(5.20%)分别提高26.38%、75.00%。经比较不同提取方法后的黑木耳组织的SEM图像,表明黑木耳组织经超声微波联用辅助提取方法后,组织结构破损严重。结果证实:超声微波联用辅助提取黑木耳黑色素的方法相较于传统溶剂法可节约溶剂的使用量,相较于超声辅助提取法所耗费的时间有所减少,并且可提升黑木耳黑色素得率。  相似文献   
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