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排序方式: 共有7816条查询结果,搜索用时 31 毫秒
1.
Wan-Li Tan Dr. Chun Zhang Yang Li Dr. Kai Guo Dr. Xiao-Wei Gao Dr. Jun Wei Dr. Dong Yi Prof. Lin Pu Prof. Dr. Qin Wang 《ChemMedChem》2021,16(23):3569-3575
Forty samples of optically active falcarindiol analogues are synthesized by using the easily available C2 symmetric (R)- and (S)-1,1’-binaphth-2-ol (BINOL) in combination with Ti(OiPr)4, Zn powder and EtI. Their anticancer activities on Hccc-9810, HepG2, MDA-MB-231, Hela, MG-63 and H460 cells are assayed to elucidate their structure-activity relationships. These results showed that the falcarindiol analogue (3R,8S)- 2 i with the terminal double bond has the most potent anti-proliferation effect on Hccc-9810 cells with IC50 value of 0.46 μM. The falcarindiol analogue (3R,8S)- 2 i can induce obvious Hccc-9810 cell apoptosis in a concentration-dependent manner by Hoechst staining and flow cytometry analysis. The proposed mechanism suggests that the falcarindiol analogue (3R,8S)- 2 i increases LDH release and MDA content, and reduces the levels of SOD activity, which lead to the accumulation of oxidative stress and induce apoptosis in Hccc-9810 cells. 相似文献
2.
瞬态剂量率辐射试验会引起集成电路发生损伤或失效,其原因至少有两种:闭锁大电流引起的电路内部金属互连熔融;累积电离总剂量引起的氧化层电荷造成阈值电压偏移。本文以一种0.13 μm体硅CMOS处理器为对象,研究了瞬态剂量率和稳态电离总剂量辐射效应规律。结果表明:瞬态剂量率闭锁效应对处理器造成了显著的潜在损伤,导致其总剂量失效阈值从1 030 Gy(Si)降低至600 Gy(Si)。研究结论对于大规模集成电路的可靠性评估和指导辐射加固设计有重要参考意义。 相似文献
3.
The Pythagorean fuzzy set (PFS) is characterized by two functions expressing the degree of membership and the degree of nonmembership, which square sum of them is equal or less than 1. It was proposed as a generalization of a fuzzy set to deal with indeterminate and inconsistent information. In this study, we shall present some novel Dice similarity measures of PFSs and the generalized Dice similarity measures of PFSs and indicates that the Dice similarity measures and asymmetric measures (projection measures) are the special cases of the generalized Dice similarity measures in some parameter values. Then, we propose the generalized Dice similarity measures-based multiple attribute group decision-making models with Pythagorean fuzzy information. Then, we apply the generalized Dice similarity measures between PFSs to multiple attribute group decision making. Finally, an illustrative example is given to demonstrate the efficiency of the similarity measures for selecting the desirable ERP system. 相似文献
4.
本文研究了微量Zr对不对称轧制Al-0.8Mg-0.9Si合金板及其相继固溶处理后的微观结构及性能的影响。结果表明:微量Zr在Al-0.8Mg-0.9Si合金中形成Al3Zr相弥散分布在基体中,在不对称轧制过程中,该化合物相对Copper{112}<111>、Brass{011}<211>、S{123}<634>、E{111}<110>和F{111}<112>等形变织构无明显影响;在随后的固溶处理过程中,轧制板材发生的再结晶使得Copper、Brass、S等形变织构的取向密度降低,但不溶的细小Al3Zr相在一定程度上抑制了不连续再结晶行为,反而使轧制过程中形成的E、F剪切织构的取向密度增加。添加微量Zr所形成的上述结构使该合金板材在固溶后获得较好的综合性能,其抗拉强度、屈强比和延伸率分别可达230MPa、0.49和9.5%以上;塑性应变比r值从0.7提高至0.84,杯突值IE由8.94提高至9.84,各向异性度|Δr|由0.15降低至0.04。 相似文献
5.
运用正交试验法开展了具有非对称NACA翼型的垂直轴潮流能水轮机的非定常数值模拟研究,分析弯度、弯度位置、前缘半径、最大厚度位置对叶轮能量提取率的影响。使用极差分析法确定了各因素影响的主次顺序和各尖速比下由最优参数确定的翼型。结果表明:在不同尖速比下,弯度是影响水轮机性能的主导因素,对水轮机能量提取率的贡献率分别为44.7%(尖速比λ=2.25)、53.4%(尖速比λ=2.5)和59.4%(尖速比λ=2.75);次要因素为最大厚度所在位置,其余两个参数对其性能影响较小。针对最优参数确定的翼型进行验证,结果证实具有该翼型的水轮机的动力学性能要好于其他翼型。 相似文献
6.
The asymmetric plate heat exchanger (APHE) has the possibility of achieving balanced pressure drops on both hot and cold sides for situations with unbalanced flow, which may in turn enhance the heat transfer. In this paper, the single-phase water flow and heat transfer of an APHE consisted of two types of plates are numerically (400≤Re≤12000) and experimentally (400≤Re≤ 3400) investigated. The numerical model is verified by the experimental results. Simulations are conducted to study the effects of N, an asymmetric index proposed to describe the geometry of APHEs. The correlations of the Nusselt number and friction factor in the APHEs are determined by taking N and working fluids into account. It is found that an optimal N exists where the pressure drops are balanced and the heat transfer area reaches the minimum. The comparison between heat transfer and flow characteristics of the APHEs and the conventional plate heat exchanger (CPHE) is made under various flow rate ratios of the hot side and the cold side and different allowable pressure drops. The situations under which APHE may perform better are identified based on a comprehensive index Nu/f1/3. 相似文献
7.
Shibendu Mahata Rajib Kar Durbadal Mandal 《International Journal of Circuit Theory and Applications》2020,48(9):1554-1560
In this letter, the optimal rational approximation of fractional-order bandpass Butterworth filter (FOBBF) is presented. The transfer function of the FOBBF is decomposed into a multiplication of first-order and second-order terms. As a result, the design stability conditions can be easily satisfied using only the variable boundary constraints. The proposed technique generalizes the symmetric fractional-order roll-off characteristic as only a special case of the asymmetric one. Several examples are presented to validate the modeling efficacy. 相似文献
8.
Xiaorui Gao Ximeng Liu Dajun Wu Bin Qian Zongkui Kou Zhenghui Pan Yajun Pang Linqing Miao John Wang 《Advanced functional materials》2019,29(36)
The Al effect on the electrochemical properties of layered double hydroxides (LDHs) is not properly probed, although it is demonstrated to notably promote the capacitive behavior of LDHs. Herein, ternary NiCo2Alx layered double hydroxides with varying levels of Al stoichiometry are purposely developed, grown directly on mechanically flexible and electrically conducting carbon cloth (CC@NiCo2Alx‐LDH). Al plays a significant role in determining the structure, morphology, and electrochemical behavior of NiCo2Alx‐LDHs. At an increasing level of Al in NiCo2Alx‐LDHs, there is a steady evolution from 1D nanowire to 2D nanosheets. The CC@NiCo2Al‐LDH at an appropriate level of Al and with the nanowire–nanosheet mixed morphology exhibits both significantly enhanced electrochemical performance and excellent structural stability, with about a 2.3‐fold capacitance of NiCo2‐OH. When applied as the anode in a flexible asymmetric supercapacitor (ASC), the CC@NiCo2Al‐LDH gives rise to a remarkable energy density of 44 Wh kg?1 at the power density of 462 W kg?1, together with remarkable cyclic stability with 91.2% capacitance retention over 15 000 charge–discharge cycles. The present study demonstrates a new pathway to significantly improve the electrochemical performance and stability of transition metal LDHs, which are otherwise unstable in structure and poorly performing in both rate and cycling capability. 相似文献
9.
Sebastian Roth Peter Stockinger Jakob Steff Simon Steimle Dr. Viktor Sautner Prof. Dr. Kai Tittmann Prof. Dr. Jürgen Pleiss Prof. Dr. Michael Müller 《Chembiochem : a European journal of chemical biology》2020,21(18):2615-2619
The family of NAD(P)H-dependent short-chain dehydrogenases/reductases (SDRs) comprises numerous biocatalysts capable of C=O or C=C reduction. The highly homologous noroxomaritidine reductase (NR) from Narcissus sp. aff. pseudonarcissus and Zt_SDR from Zephyranthes treatiae, however, are SDRs with an extended imine substrate scope. Comparison with a similar SDR from Asparagus officinalis (Ao_SDR) exhibiting keto-reducing activity, yet negligible imine-reducing capability, and mining the Short-Chain Dehydrogenase/Reductase Engineering Database indicated that NR and Zt_SDR possess a unique active-site composition among SDRs. Adapting the active site of Ao_SDR accordingly improved its imine-reducing capability. By applying the same strategy, an unrelated SDR from Methylobacterium sp. 77 (M77_SDR) with distinct keto-reducing activity was engineered into a promiscuous enzyme with imine-reducing activity, thereby confirming that the ability to reduce imines can be rationally introduced into members of the “classical” SDR enzyme family. Thus, members of the SDR family could be a promising starting point for protein approaches to generate new imine-reducing enzymes. 相似文献
10.
为了开发β受体阻断剂新药(S)-噻吗洛尔半水合物,采用3-吗啉-4-氯-1,2,5-噻二唑为起始原料,经水解反应得到中间体1(3-吗啉-4-羟基-1,2,5-噻二唑)。中间体1与R-环氧氯丙烷发生醚化反应,经后处理及重结晶得到中间体2 {(R)-4-[4-(环氧乙烷-2-基甲氧基)-1,2,5-噻二唑-3-基]吗啉}。中间体2经胺化反应、马来酸成盐及重结晶得到(S)-马来酸噻吗洛尔。(S)-马来酸噻吗洛尔经游离、纯水转晶得到符合药典标准的(S)-噻吗洛尔半水合物,总收率14.05%且e.e.值为99.66%。最终成品经IR、1H-NMR、13C-NMR、MS、TGA、DSC表征,并优化各步反应条件。结果表明:以三乙胺为醚化反应缚酸剂75 ℃反应最佳;以乙醇为胺化反应溶剂46 ℃反应16 h最佳;S-噻吗洛尔的转晶拆分以水作溶剂,比传统不对称合成工艺安全稳定,操作简单,适合工业化生产。 相似文献