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《Drug development and industrial pharmacy》2013,39(9):1100-1109
Background: In recent years, many achievements have been realized in the therapy of inflammatory bowel disease (IBD) although its etiology remains unknown. Thus IBD treatment is symptomatic and targets general inflammatory mechanisms. Oral formulations containing 5-aminosalicylic acid (5-ASA) have become the standard therapy for mild-to-moderate IBD.Objective: This article is a review of recently published research dealing with new 5-ASA dosage forms. Thus promising candidates for IBD treatment evaluated in vitro are reported; systems tested in vivo in trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats are mentioned; and 5-ASA formulations used in clinical studies are presented. Moreover, all oral dosage forms containing 5-ASA or its prodrugs are reviewed; their characteristics and utilization in IBD treatment are discussed.Conclusion: In several clinical studies, it has been shown that multiparticulates such as pellets offer more advantages as compared with single unit forms, that is, coated tablets. Prolonged presence close to the site of the action, improved drug bioavailability, and easier administration of large drug doses belong to the benefits of pellets. 相似文献
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In December of 2010 NIST selected five SHA-3 finalists - BLAKE,Grφstl,JH,Keccak,and Skein to advance to the third (and final) round of the SHA-3 competition.At present most specialists and scholars foc... 相似文献
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改进的灰色拓扑预测结合了GM(1,1)模型、拓扑预测与最小二乘法.它通过对一些具有波动性的少量数据进行分析得出比较接近实际的预测值,较大程度上减少了误差.本文通过使用该算法,很好地对高考考生填报志愿时要报考学校的下一年分数进行了预测,验证了它的实际运用价值. 相似文献
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Reports an error in "When your top choice turns you down: Effect of rejected offers on the utility of selection tests" by Kevin R. Murphy (Psychological Bulletin, 1986[Jan], Vol 99[1], 133-138). There was an error in the last line of Table 1, which appears on page 137. The corrected version is presented in the erratum. (The following abstract of the original article appeared in record 1986-15964-001.) Develops formulas for calculating the average ability of job candidates actually selected when the proportion of initial offers accepted is less than 100%. Three cases are considered: (a) those in which offers are declined at random, (b) those in which offers are declined by the highest-scoring applicants, and (c) those in which test scores are related to the probability of accepting an offer. It is shown that under realistic circumstances, utility formulas currently used could overestimate utility gains by 30–80% and that, under extreme circumstances, overestimation could be much worse. Such overestimation occurs even when tests are used only for screening rather than for rank-ordering candidates. (16 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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Coaching CEO successor candidates is challenging and deeply nuanced in the best of circumstances. The stakes rise exponentially when the sitting CEO owns the company, resents having "anointed" an eventual successor, and has been phenomenally successful despite the bruising effects of his narcissism and toxic micromanagement. This case study describes how a data-driven, insight-oriented coaching methodology helped the CEO candidate accelerate his effectiveness, instill hope in the organization, and forge a more stable relationship with the CEO--a sufficiently functional relationship for the future CEO to decide to remain with the company. Furthermore, this work highlights the importance of clinical skills and 3 coaching meta principles (traction, trust, and truth-telling). Finally, this longer term coaching engagement illustrates the dynamic role shift from coach to trusted advisor. Through this deepened relationship, coaching gains were consolidated and an objective sounding board was retained for both the CEO and his eventual successor. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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基于项目集知识库的关联规则挖掘与更新的高效算法 总被引:2,自引:2,他引:2
通过对已有的诸关联规则挖掘与更新算法进行深入的分析和研究,指出了其共同存在的问题与不足,提出了一种基于项目集知识库的关联规则挖掘与更新方法。该方法既适应当数据库D中数据不变而用户指定的最小支持度和最小置信度这两个阈值变化的情况,也适合事务数据库D中数据发生变化的情况。当事务数据库D中数据不变时,仅需扫描数据库一次,便可建立项目集知识库KBD,然后可反复调整最小支持度和最小置信度进行关联规则挖掘与更新。而当事务数据库D中数据发生变化时,仅需扫描数据集d 和d-各一次;通过对项目集知识库KBD的更新来达到对频繁项目集和关联规则的更新。 相似文献
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Quality control is a critical aspect of the modern electronic circuit industry. In addition to being a pre-requisite to proper functioning, circuit quality is closely related to safety, security, and economic issues. Quality control has been reached through system testing. Meanwhile, device miniaturization and multilayer Printed Circuit Boards have increased the electronic circuit test complexity considerably. Hence, traditional test processes based on manual inspections have become outdated and inefficient. More recently, the concept of Advanced Manufacturing or Industry 4.0 has enabled the manufacturing of customized products, tailored to the changing customers’ demands. This scenario points out additional requirements for electronic system testing: it demands a high degree of flexibility in production processes, short design and manufacturing cycles, and cost control. Thus, there is a demand for circuit testing systems that present effectiveness and accessibility without placing numerous test points. This work is focused on automated test solutions based on machine learning, which are becoming popular with advances in computational tools. We present a new testing approach that uses autoencoders to detect firmware or hardware anomalies based on the electric current signature. We built a test set-up using an embedded system development board to evaluate the proposed approach. We implemented six firmware versions that can run independently on the test board – one of them is considered anomaly-free. In order to obtain a reference frame to our results, two other classification techniques (a computer vision algorithm and a random forest classification model) were employed to detect anomalies on the same development board. The outcomes of the experiments demonstrated that the proposed test method is highly effective. For several test scenarios, the correct detection rate was above 99%. Test results showed that autoencoder and random forest approaches are effective. However, random forests require all data classes to be trained. Training an autoencoder, on the other hand, only requires the reference (anomaly-free) class. 相似文献
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黄祖贤 《安徽工业大学学报》2015,32(2)
将"数独"问题分解为建立终盘、生成有唯一解初盘和求解初盘等子问题。运用拉斯维加斯随机算法思想结合回溯法建立终盘,采用"挖洞"思想隐去部分数字并结合反序回溯法生成具有唯一解的初盘,依据初盘中空格数的多少对问题的难度进行划分,创建不同等级难度的"数独"游戏,并对求解数独问题的候选数搜索算法进行优化改进。实例分析结果表明,优化后的候选数搜索算法性能提高了50%以上,验证了所提出算法模型的有效性。 相似文献