来流马赫数影响高负荷扇形扩压叶栅气动性能的研究

为研究亚音速高负荷扇形扩压叶栅NACA0065-K48的变工况性能,采用数值方法研究了来流马赫数对叶栅气动性能和流场结构的影响,来流马赫数的取值范围为0.3～0.8。计算结果表明:随着来流马赫数的增大,叶栅静压比不断提高,但总压损失先减后增,马赫数在0.5～0.7范围内叶栅具有较好的综合气动性能。扇形叶栅下角区分离程度大于上角区的不平衡流动现象会随着马赫数的增大而加剧,通道涡则是这一发展趋势的主导,且马赫数达到0.7之后,下角区通道涡与集中脱落涡趋于融合。此外,下端壁分离螺旋点的形成与发展是控制下角区分离程度和损失大小的关键。     

Nanoconfined (Bio)Catalysts as Efficient Glucose‐Responsive Nanoreactors

Herein, the design, synthesis, and characterization of bifunctional hybrid nanoreactors used for concurrent one‐pot chemoenzymatic reactions are shown. In the design, the enzyme, glucose oxidase, is wrapped with a peroxidase‐mimetic catalytic polymer. Hemin, the organic catalyst, is linked to the flexible polymeric scaffold through coordination to the imidazole groups that hang out the network. This spatial arrangement, which works as a metabolic channel, is optimized for cooperative chemoenzymatic reactions in which the enzyme catalyzes first. A deep characterization of the integrated nanoreactors demonstrates that the confinement of two distinct catalytic sites in the nanospace is very effective in one‐pot reactions. Moreover, besides its role as scaffold material, the polymeric mantel protects both the biocatalyst and the chemical catalyst from degradation and inactivation in the presence of organic solvents. Furthermore, the polymeric environment of the nanoreactors can be tailored in order to trigger the assembly of those into highly active heterogeneous hybrid catalysts. Finally, the new nanoreactors are applied to the efficient degradation of organic aromatic compounds using glucose as the only fuel.     

袁河新泉乡段梯级溢流堰水动力模拟及侵蚀分析

为了分析梯级溢流堰对袁河新泉乡段河道行洪及河床抗冲的影响,优化河道治理工程中溢流堰布置,建立了将拦河溢流堰作为闭边界条件的二维水动力数值模型,采用非结构化网格的有限体积法,对比分析了十年一遇洪水情况下梯级溢流堰建设前后河道水动力、河道水位、流场沿程变化特征,讨论了溢流堰布置对河道防洪及冲刷的影响。结果表明,在十年一遇洪水情况下溢流堰会抬升河道水位,平均增加0.49 m,满足河道行洪要求;梯级溢流堰使河道整体形成人工“阶梯深潭”体系,河道流速在空间上发生明显的异质性,堰上流速下降幅度较堰下流速大;水流发生急流与缓流之间交替,水流紊动强烈,加剧了水流能量损失,有效降低流速,减轻了河道冲刷,有利于稳定河岸结构。     

A Topical Formulation of Melatoninergic Compounds Exerts Strong Hypotensive and Neuroprotective Effects in a Rat Model of Hypertensive Glaucoma

Melatonin is of great importance for regulating several eye processes, including pressure homeostasis. Melatonin in combination with agomelatine has been recently reported to reduce intraocular pressure (IOP) with higher efficacy than each compound alone. Here, we used the methylcellulose (MCE) rat model of hypertensive glaucoma, an optic neuropathy characterized by the apoptotic death of retinal ganglion cells (RGCs), to evaluate the hypotensive and neuroprotective efficacy of an eye drop nanomicellar formulation containing melatonin/agomelatine. Eye tissue distribution of melatonin/agomelatine in healthy rats was evaluated by HPLC/MS/MS. In the MCE model, we assessed by tonometry the hypotensive efficacy of melatonin/agomelatine. Neuroprotection was revealed by electroretinography; by levels of inflammatory and apoptotic markers; and by RGC density. The effects of melatonin/agomelatine were compared with those of timolol (a beta blocker with prevalent hypotensive activity) or brimonidine (an alpha 2 adrenergic agonist with potential neuroprotective efficacy), two drugs commonly used to treat glaucoma. Both melatonin and agomelatine penetrate the posterior segment of the eye. In the MCE model, IOP elevation was drastically reduced by melatonin/agomelatine with higher efficacy than that of timolol or brimonidine. Concomitantly, gliosis-related inflammation and the Bax-associated apoptosis were partially prevented, thus leading to RGC survival and recovered retinal dysfunction. We suggest that topical melatoninergic compounds might be beneficial for ocular health.     

基于复合相变材料的梯级组合蓄热特性研究

针对潜热蓄热装置内部相变材料（PCM）导热系数偏小，蓄热速率过低的问题，对基于复合相变材料的两级串联式梯级蓄热装置的相变过程进行了数值研究。通过对不同热物性PCM工况的对比与分析，得到了装置在不同工况下的蓄热特性。结果表明，存在最佳的热扩散系数，使固定熔点的PCM实现“均匀等速相变”。同时，增大PCM的热扩散系数可以有效降低加热面温度，但随着热扩散系数的增大，加热面温度降低幅度减小。通过分析Stefan数，得到了装置最佳的参数，使工况蓄热效果最佳。最后，通过Stefan数为2.88时的实验工况验证了相关规律的正确性。     

一种超长级联国际传输专线故障机器定位算法的研究

国际电路不同于一般网内电路，具有跨多运营商、超长距离和级联组网的特性，这些特性给该类电路的故障定位带来挑战，但同时也形成其特有的规律。本文通过总结日常运维经验和分析各厂家设备告警信号传递规律，总结出可以用于计算机实现的国际电路故障定位算法。     

淮河入江水道行洪能力分析

入江水道是淮河下游最大的泄洪河道,承担着淮河上中游70%以上的洪水泄入长江。根据1961—2018年大洪水期间的实测资料,利用水位流量法计算分析入江水道的泄洪能力和防洪能力。结果表明:因历史客观条件限制以及4个梯级控制河段整治的难度与复杂性,在不同时期各控制河段的行洪能力呈现各自不同的特点;经过多年持续有效治理,河道行洪能力整体得到提高;由近年来实测资料推算,各控制河段的行洪能力基本达到设计要求。对入江水道行洪能力的分析为淮河下游区的防汛抗洪和降低特大洪水威胁提供借鉴和参考,对区域经济社会又好又快发展具有现实意义。     

Update on the Roles of Rice MAPK Cascades

The mitogen-activated protein kinase (MAPK) cascades have been validated playing critical roles in diverse aspects of plant biology, from growth and developmental regulation, biotic and abiotic stress responses, to phytohormone signal transduction or responses. A classical MAPK cascade consists of a MAPK kinase kinase (MAPKKK), a MAPK kinase (MAPKK), and a MAPK. From the 75 MAPKKKs, eight MAPKKs, and 15 MAPKs of rice, a number of them have been functionally deciphered. Here, we update recent advances in knowledge of the roles of rice MAPK cascades, including their components and complicated action modes, their diversified functions controlling rice growth and developmental responses, coordinating resistance to biotic and abiotic stress, and conducting phytohormone signal transduction. Moreover, we summarize several complete MAPK cascades that harbor OsMAPKKK-OsMAPKK-OsMAPK, their interaction with different upstream components and their phosphorylation of diverse downstream substrates to fulfill their multiple roles. Furthermore, we state a comparison of networks of rice MAPK cascades from signal transduction crosstalk to the precise selection of downstream substrates. Additionally, we discuss putative concerns for elucidating the underlying molecular mechanisms and molecular functions of rice MAPK cascades in the future.     

IGCT在矿井提升机斩波串级调速系统中的应用

将斩波串级调速方案应用于改造绕线式异步电机的矿井提升机电控系统,不仅克服了有级调速的缺点,而且采用闭环控制,使调速性能大大改善,逆变器的容量大为减小,大大改善电机拖动系统的功率因数。