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排序方式: 共有1624条查询结果,搜索用时 15 毫秒
1.
Guglielmina Chimienti Anna Picca Flavio Fracasso Francesco Russo Antonella Orlando Giuseppe Riezzo Christiaan Leeuwenburgh Vito Pesce Angela Maria Serena Lezza 《International journal of molecular sciences》2021,22(4)
Calorie restriction (CR) is the most efficacious treatment to delay the onset of age-related changes such as mitochondrial dysfunction. However, the sensitivity of mitochondrial markers to CR and the age-related boundaries of CR efficacy are not fully elucidated. We used liver samples from ad libitum-fed (AL) rats divided in: 18-month-old (AL-18), 28-month-old (AL-28), and 32-month-old (AL-32) groups, and from CR-treated (CR) 28-month-old (CR-28) and 32-month-old (CR-32) counterparts to assay the effect of CR on several mitochondrial markers. The age-related decreases in citrate synthase activity, in TFAM, MFN2, and DRP1 protein amounts and in the mtDNA content in the AL-28 group were prevented in CR-28 counterparts. Accordingly, CR reduced oxidative mtDNA damage assessed through the incidence of oxidized purines at specific mtDNA regions in CR-28 animals. These findings support the anti-aging effect of CR up to 28 months. Conversely, the protein amounts of LonP1, Cyt c, OGG1, and APE1 and the 4.8 Kb mtDNA deletion content were not affected in CR-28 rats. The absence of significant differences between the AL-32 values and the CR-32 counterparts suggests an age-related boundary of CR efficacy at this age. However, this only partially curtails the CR benefits in counteracting the generalized aging decline and the related mitochondrial involvement. 相似文献
2.
D.R. Santos‐Peñate C.M. Campos‐Rodríguez J.A. Moreno‐Pérez 《International Transactions in Operational Research》2019,26(1):340-363
The ‐centroid problem or leader–follower problem is generalized considering different customer choice rules where a customer may use facilities belonging to different firms, if the difference in travel distance (or time) is small enough. Assuming essential goods, some particular customer choice rules are analyzed. Linear programming formulations for the generalized ‐medianoid and ‐centroid problems are presented and an exact solution approach is applied. Some computational examples are included. 相似文献
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为提高煤矿井下人员定位的精确性,确保井下人员的快速定位,以实现井下快速救援和日常监督,本文根据无线接入点的关联性,通过接收信号强度值(RSSI)计算参考节点和定位节点的距离,提出基于改进RSSI加权质心算法的井下人员定位技术,消除了传统改进RSSI定位算法中人为因素对路径损耗确定的干扰。根据实际巷道环境进行了基于RSSI加权质心算法和改进RSSI加权质心算法的人员信息定位技术的模拟仿真,结果证明了改进RSSI加权质心算法能够增加井下人员定位的精准可靠性,更加适用于井下定位系统。 相似文献
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Ji Eun Du Young Ah You Eun Jin Kwon Soo Min Kim Jeongae Lee Ki Hwan Han Young Ju Kim 《International journal of molecular sciences》2020,21(23)
Fetal programming implies that the maternal diet during pregnancy affects the long-term health of offspring. Although maternal diet influences metabolic disorders and non-alcoholic fatty liver disease in offspring, the hepatic mechanisms related to metabolites are still unknown. Here, we investigated the maternal diet-related alterations in metabolites and the biological pathway in male offspring at three months of age. Pregnant rats were exposed to 50% food restriction during the prenatal period or a 45% high-fat diet during the prenatal and postnatal periods. The male offspring exposed to food restriction and high-fat diets had lower birth weights than controls, but had a catch-up growth spurt at three months of age. Hepatic taurine levels decreased in both groups compared to controls. The decreased hepatic taurine levels in offspring affected excessive lipid accumulation through changes in hepatocyte nuclear factor 4 A methylation. Moreover, the alteration of gluconeogenesis in offspring exposed to food restriction was observed to a similar extent as that of offspring exposed to a high fat diet. These results indicate that maternal diet affects the dysregulation in hepatic metabolism through changes in taurine levels and HNF4A methylation, and predisposes the offspring to Type 2 diabetes and non-alcoholic fatty liver disease in later life. 相似文献
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为了增强桥梁抗御地震落梁的能力,减轻交通生命线系统的震害损失,基于耗能减震、多级设防和结构分灾三个抗震性能设计理念,设计了一种具有耗能限位和上部体系连续化两级功能,并能在不同水准地震下自动实现功能转换的地震落梁控制装置。首先,分析了装置的构成、特点和工作机理,对第1级耗能限位组件进行了拟静力试验,测试了耗能滞回曲线;然后,对第2级拉索连梁组件进行了静力拉伸试验,评价了其变形性能、破坏形式和锚固性能;最后,对抗震销栓进行了剪切试验,考察了控制级别的转换,采用试验结果对有限元模拟结果进行了验证。研究表明,地震落梁两级控制装置具有有效的位移约束、合理的耗能机制和明确的分灾保险丝构造,实现了梁-梁连接和墩-梁连接控制模式的优势互补,实现了强震作用下对桥梁落梁失效的控制和对桥墩的安全保护。 相似文献
9.
Juliane Resges Orives Diego Galvan Jaqueline Laís Pereira Rodolfo Lopes Coppo Dionísio Borsato 《Journal of the American Oil Chemists' Society》2014,91(10):1805-1811
Oxidation stability is a parameter of great importance for biodiesel quality control to both producers and subsequent consumers. To maintain the quality of biodiesel, currently the most effective and economical method is the addition of antioxidants that prevent or retard the biofuel oxidation reaction. In this study, efficiency and cost of synthetic antioxidants added to B100 biodiesel from soybean oil and pork fat were evaluated, using butylhydroxyanisole (BHA), butylhydroxytoluene (BHT) and tert-butylhydroquinone (TBHQ), in pure form or in mixtures, according to a simplex-centroid mixture experimental design. Results demonstrate an increased induction period (IP) in all trials when compared to the control sample, and TBHQ was the only antioxidant alone that met all the specification standards, while BHT and BHA alone met only the American standard specifications. The antioxidant mixture that presented the highest synergistic effect was that of TBHQ and BHA. Multi-response optimization indicated an optimum formulation containing 75 % TBHQ and 25 % BHA with an IP of 7.27 h at 110 °C and the antioxidant mixture cost of 31.31 USD, to be added for a ton of biodiesel. This simplex-centroid mixture experimental design shows an ability to be applied in the biodiesel, oils and fats industry to evaluate the oxidation stability and the occurrence of synergism between different mixtures of synthetic or natural antioxidants and their costs. 相似文献
10.
通过有限元分析软件ANSYS分析了设置预制刚性垫块的承重纵墙的梁端约束力矩,并将有限元分析结果与梁端固端弯矩进行了比较,讨论了梁端约束力矩的变化规律。 相似文献