草原石林：东北亚早白垩世花岗岩伸展穹隆和岩浆成矿爆发的地质遗迹及其形成过程

东北亚地区至少发育9个大型草原石林,属花岗岩石林的一种,是东北亚早白垩世巨量伸展和第四系冰川、风化作用的共同产物,主要特点是发育密集的近水平节理。本文通过整理岩浆岩专题填图和构造研究发现,这些石林的主体是早白垩世东北亚地区巨量伸展过程中形成众多的不对称花岗岩穹隆或同减薄岩体,岩体边部发育韧性剪切带,核部发布近水平岩浆流动面理,伸展和岩浆多期侵位导致与成矿密切相关的岩浆热液大量上涌,岩体抬升至地表,沿岩浆面理发育密集的近水平节理和部分垂直节理,后期沿这些构造面理发生的物理风化和化学作用(包括风蚀、冰川以及盐风化等)造就了千奇百怪的形态。草原石林是花岗岩地貌中的“另类”,不仅具有指示东北亚地区花岗岩形成时代(早白垩世)的特点,也是寻找晚中生代中国北方大规模成矿的良好标志体,而且风化形成的千姿百态的景色极具观赏价值,可以作为整个蒙古草原地区和大兴安岭南段地区特色的地学科普和生态旅游资源。     

歧口凹陷断裂密集带形成演化特征及油气富集差异研究

断裂密集带作为斜向伸展作用的标志性产物,是断块油气藏形成与聚集的主要场所。针对歧口凹陷不同走向断裂密集带油气富集差异较大的问题,通过统计密集带几何学特征及构造组合样式,结合断裂带形成演化规律,分析不同走向断裂带油气富集差异。结果表明:歧口凹陷主要发育NEE、EW向及NNE向3种断裂带。其中,NNE向断裂带形成时期最早,断裂的垂向输导能力最弱,油气在深部富集;NEE向断裂带随后形成,断裂对盖层的破坏作用最强,油气在深、浅层均有分布;EW向断裂带形成时期最晚,断裂的垂向输导能力介于前两者之间。研究成果可为歧口凹陷及相似的多期裂陷盆地断裂密集带的油气勘探工作提供理论支撑。     

基于文本与语义相关性分析的图像检索

为了更加有效地检索到符合用户复杂语义需求的图像，提出一种基于文本描述与语义相关性分析的图像检索算法。该方法将图像检索分为两步：基于文本语义相关性分析的图像检索和基于SIFT特征的相似图像扩展检索。根据自然语言处理技术分析得到用户文本需求中的关键词及其语义关联，在选定图像库中通过语义相关性分析得到“种子”图像；接下来在图像扩展检索中，采用基于SIFT特征的相似图像检索，利用之前得到的“种子”图像作为查询条件，在网络图像库中进行扩展检索，并在结果集上根据两次检索的图像相似度进行排序输出，最终得到更加丰富有效的图像检索结果。为了证明算法的有效性，在标准数据集Corel5K和网络数据集Deriantart8K上完成了多组实验，实验结果证明该方法能够得到较为精确地符合用户语义要求的图像检索结果，并且通过扩展算法可以得到更加丰富的检索结果。     

用于快速服装搭配的FMatchNet算法

目的 针对现有服装搭配系统中，提取服装图像深度特征进行搭配所需时间过长的问题，提出了一种新的FMatchNet网络提取哈希特征进行服装快速搭配的方法。方法 首先采用快速区域卷积神经网络（Faster-RCNN）方法检测出图像中的服装，用此服装进行搭配可以最大限度地保留服装信息并消除背景信息的干扰。然后用深度卷积神经网络提取服装的深度特征并产生服装的哈希码，采用查询扩展的方法完成服装搭配。模型采用Siamese网络的训练方法使哈希码尽可能保留服装图像的语义信息。另外，由于目前国际上缺少大型时尚服装数据库，本文扩建了一个细粒度标注的时尚服装数据库。结果 在FClothes数据库上验证本文方法并与目前流行的方法进行对比，本文方法在哈希长度为16时，上、下服装搭配方面的准确度达到了50.81%，搭配速度相对于基本准线算法提高了近3倍。结论 针对大规模服装搭配问题，提出一种新的FMatchNet网络提取特征进行服装快速搭配的方法，提高了服装搭配的精度和速度，适用于日常服装搭配。     

天然气中C+6组成分析不同定量方式对计算烃露点的影响

由天然气组成数据计算烃露点是获取烃露点的一种重要的检测方法,天然气组成分析已有相关方法标准,但对于C_6~+组成分析有不同的定量和数据处理方式。概述了计算烃露点的主要影响因素,重点分析了C_6~+延伸组成分析不同定量方式对计算烃露点结果的影响。采用气相色谱法分析了两个实际天然气样品,根据不同的定量方法和数据处理方式获得的C_6~+延伸组成数据预测了天然气的烃露点。结果表明,对于C_6~+延伸组成的分析,C_6～C_(16)按碳数归类,其中苯、甲苯、环己烷和甲基环己烷等组分单独定量时,由此获得完整天然气组成数据计算的烃露点和直接测定烃露点平均偏差在3℃以内,初步验证了计算法和直接测定法获得的烃露点结果的一致性。     

Functions of ULK1 in autophagy and non-autophagy pathways and its implications in human physiology and disease

ULK1 (unc-51 like autophagy activating kinase 1), a mammalian serine/threonine kinase, is a key component of autophagy initiation complex and helps to induce all types of autophagy. Canonical autophagy is a process in which, through the interactions of a series of autophagy-related proteins, damaged organelles or misfolded proteins are engulfed by autophagosomes and then merged with lysosomes to be degraded. Thus, canonical autophagy is an important constituent part of the cellular “quality control.” Besides, accumulating evidence indicates that ULK1 exerts autophagy-independent effects in a cell-specific manner. For example, ULK1 facilitates neurite elongation through the regulation of endoplasmic reticulum (ER)–Golgi trafficking in neurons, stimulates phosphopentose pathway to help NADPH (nicotinamide adenine dinucleotide phosphate hydrogen) production, and acts as a duplex regulator in type I IFN (type I interferon) induced innate immune response. Considering the importance and diversity of ULK1 in various biological processes, this review aims to present a comprehensive overview of autophagy and non-autophagy related functions of ULK1 in a variety of human physiological, pathological, and disease processes.     

煤矿井下小断层延伸长度定量化预测研究

以山西A矿开采的3号煤层采掘活动已揭露的小断层资料为基础,选取断层落差、倾角、延伸长度3个参数,通过多线性回归方法构建NW、NE 2个方向的断层延伸长度预本构模型,并进行现场应用。结果表明,构建的小断层预测模型预测的小断层延伸长度的准确率在90%以上,可以为后续揭露小断层延伸长度的确定提供可靠的参数指导。     

Thermo-rheological analysis of various chain extended recycled poly(ethylene terephthalate)

Three chain extenders, pyromellitic dianhydride (PMDA), ethylene carbonate (EC), and a polymeric-epoxide, were investigated for improving recycled p(ethylene terephthalate) (r-PET) properties with melt extrusion. The amount of additives and processing temperatures were also varied to check for melt degradation. Small amplitude oscillatory shear experiments were performed to probe rheological changes with different chain extenders. Capillary rheometry with haul-off was also performed to measure extensional viscosity and melt strength. Higher loadings of the chain extenders were found to improve properties of r-PET. These chain extenders definitely increased melt viscosities when incorporated at the higher level of the ranges examined, matching that of virgin PET. EC addition resulted in high shear thinning of the polymer. Epoxy and PMDA added to r-PET produced products with the same extensional viscosity as v-PET. Haul-off experiments demonstrate superior performance by epoxy-modified r-PET compared to v-PET.     

亚磷酸酯功能化聚硅氧烷扩链聚乳酸的阻燃性能研究

将聚氨基环氧基硅氧烷（PSQ）以及亚磷酸酯功能化的聚氨基环氧基硅氧烷（PPSQ）与聚乳酸（PLA）通过熔融共混制备了扩链PLA。研究了亚磷酸酯基团的引入对PSQ在PLA中的扩链和阻燃性能的影响，探究PPSQ在PLA中的阻燃机理。结果表明，相比于PSQ，PPSQ可以明显提高PLA的分子量和复合黏度，具有更好的扩链作用；PPSQ的引入可以明显改善PLA的阻燃性能，使得PLA?PPSQ的极限氧指数提高至25.4 %，比纯PLA提升了31.6 %，且使得PLA的热释放速率峰值和总热释放量分别下降了18.1 %和16.6 %。分析可知，由于亚磷酸酯基团的引入，促使PLA?PPSQ中的硅元素在燃烧过程中向炭层表面迁移形成更多富含碳化硅和氧化硅的致密炭层，起到隔热隔氧的作用，进而发挥优异的阻燃性能。     

Analysis of Cerebrospinal Fluid Extracellular Vesicles by Proximity Extension Assay: A Comparative Study of Four Isolation Kits

There is a lack of reliable biomarkers for disorders of the central nervous system (CNS), and diagnostics still heavily rely on symptoms that are both subjective and difficult to quantify. The cerebrospinal fluid (CSF) is a promising source of biomarkers due to its close connection to the CNS. Extracellular vesicles are actively secreted by cells, and proteomic analysis of CSF extracellular vesicles (EVs) and their molecular composition likely reflects changes in the CNS to a higher extent compared with total CSF, especially in the case of neuroinflammation, which could increase blood–brain barrier permeability and cause an influx of plasma proteins into the CSF. We used proximity extension assay for proteomic analysis due to its high sensitivity. We believe that this methodology could be useful for de novo biomarker discovery for several CNS diseases. We compared four commercially available kits for EV isolation: MagCapture and ExoIntact (based on magnetic beads), EVSecond L70 (size-exclusion chromatography), and exoEasy (membrane affinity). The isolated EVs were characterized by nanoparticle tracking analysis, ELISA (CD63, CD81 and albumin), and proximity extension assay (PEA) using two different panels, each consisting of 92 markers. The exoEasy samples did not pass the built-in quality controls and were excluded from downstream analysis. The number of detectable proteins in the ExoIntact samples was considerably higher (~150% for the cardiovascular III panel and ~320% for the cell regulation panel) compared with other groups. ExoIntact also showed the highest intersample correlation with an average Pearson’s correlation coefficient of 0.991 compared with 0.985 and 0.927 for MagCapture and EVSecond, respectively. The median coefficient of variation was 5%, 8%, and 22% for ExoIntact, MagCapture, and EVSecond, respectively. Comparing total CSF and ExoIntact samples revealed 70 differentially expressed proteins in the cardiovascular III panel and 17 in the cell regulation panel. To our knowledge, this is the first time that CSF EVs were analyzed by PEA. In conclusion, analysis of CSF EVs by PEA is feasible, and different isolation kits give distinct results, with ExoIntact showing the highest number of identified proteins with the lowest variability.