BMS Derivatives C7-Linked to β-Cyclodextrin and Hyperbranched Polyglycerol Retain Activity against R5-HIV-1NLAD8 Isolates and Can Be Deemed Potential Microbicides

Amides from indole-3-glyoxylic acid and 4-benzoyl-2-methylpiperazine, which are related to entry inhibitors developed by Bristol-Myers Squibb (BMS), have been synthesized with aliphatic chains located at the C7 position of the indole ring. These spacers contain an azido group suitable for the well-known Cu(I)-catalyzed (3+2)-cycloaddition or an activated triple bond for the nucleophilic addition of thiols under physiological conditions. Reaction with polyols (β-cyclodextrin and hyperbranched polyglycerol) decorated with complementary click partners has afforded polyol-BMS-like conjugates that are not cytotoxic (TZM.bl cells) and retain the activity against R5-HIV-1_NLAD8 isolates. Thus, potential vaginal microbicides based on entry inhibitors, which can be called of 4^th generation, are reported here for the first time.     

In situ 2D mapping of hydrogen entry into an Fe sheet under a droplet of NaCl solution using a hydrogenochromic sensor

The distribution of hydrogen entering an Fe sheet under a droplet of NaCl solution was successfully visualized using a hydrogenochromic sensor consisting of a polyaniline layer and a Ni intermediate layer. At the initial stage of corrosion, the hydrogen entry was barely confirmed. The hydrogen entry was observed as the corrosion proceeded, and the preferential hydrogen entry site corresponded to the rust-formed area. It was postulated that the hydrogen entry is promoted by the decrease in pH due to the hydrolysis reactions of Fe ions under the rust. The hydrogenochromic sensor paves the way for the visualization of the hydrogen entry into metals under corrosion conditions.     

水产品及养殖水中丁香酚类化合物风险研究

目的 检测水产品及养殖水中丁香酚类化合物。方法 应用食品补充检验方法BJS 201908《水产品及水中丁香酚类化合物的测定》，以海水鱼、淡水鱼、海水虾、淡水虾及养殖水作为基质，测定6种丁香酚类化合物的含量。结果 通过对实际样品测定后发现，在水产品中检出了丁香酚类化合物，主要为丁香酚，检出率为28.9%，其中海水鱼相对突出。结论 本研究为丁香酚作为渔用麻醉剂提供了方法论，为丁香酚类化合物在水产运输的合理使用提供理论依据。     

鹿台山矿沿空留巷围岩变形规律分析及补强支护设计

为缓解鹿台山煤矿矿井采掘接续紧张的状况，同时减少相邻工作面区段巷道掘进工程量，降低掘进工程费用，确保2203工作面顺利接替，对2202工作面轨道顺槽进行沿空留巷试验。根据巷道围岩地质条件，通过理论分析，并结合切顶卸压预裂爆破顶板技术，提出了切顶卸压沿空留巷支护方案。通过连续观测工作面回采期间的巷道围岩变形特征，总结了切顶卸压沿空留巷的矿压显现规律。分析结果对于鹿台山矿沿空留巷实践有一定的参考价值。     

Factors Affecting Web Disclosure Adoption in the Nonprofit Sector

ABSTRACT

Nonprofit organizations (NPOs) are strategically using their own personal website to present themselves to the public and share information. Despite the potential benefits of enhanced public confidence and trust, reduced operating costs, improved donor decision making, and increased donations, many nonprofit organizations have resisted the adoption of web disclosure. Informed by the literature on information systems (IS) adoption and technological innovation, this study examines the primary factors that influence the adoption and resistance of web disclosure. Our sample consisted of 176 survey responses from an initial group of 3,323 U.S. NPOs. The statistical results indicate that attitude toward disclosure, compatibility of disclosure with current practices, and financial readiness have a positive influence on web disclosure adoption. The findings have implications for research and practice.     

沿空切顶成巷段巷道围岩变形规律研究

以宏景塔一矿回采工作面为研究对象,基于切顶卸压无煤柱自动成巷技术原理,采用数值模拟计算和现场实测的方法,对该矿成巷段巷道围岩支承压力分布及围岩变形规律进行分析。研究结果表明:随着工作面向前推进,巷道围岩支承压力呈先增大后减小最后趋于稳定的变化趋势,支承压力稳定值为13.5 MPa;受工作面回采动压的影响,距离工作面70 m以内,锚索受力急剧增大到恒阻值、巷道围岩变形明显;距离工作面70~150 m,锚索受力迅速减小、巷道围岩变形逐渐变缓;在距离工作面150 m之后,锚索受力仅有微量变化、巷道围岩变形趋于稳定。因此确定支护体回撤保守安全位置为工作面后方150 m。工程实践表明:所设支护体回撤距离能够应对巷道围岩变形,成巷效果良好。     

东河煤矿2206工作面无煤柱自成巷关键技术研究及应用

针对传统沿空留巷采煤技术因增设巷道掘进作业造成煤炭资源浪费的问题,以东河煤矿2260工作面为工程背景,在分析该工作面地质、水文以及煤层情况的基础上,研究了无煤柱自成巷关键技术,并应用到2260工作面中,最终取得了较为理想的留巷效果,为类似综采工作面避免煤炭资源浪费和提升作业人员安全系数提供了有益借鉴.     

1226工作面切顶卸压沿空成巷技术应用研究

为解决掘进成本较高、接替紧张等问题,基于1226工作面地质条件,对运输巷进行切顶卸压沿空留巷设计,主要包括切顶预裂缝、恒阻大变形锚索和巷道支护参数的设计,取得较好效果。     

厚煤层构造带切顶卸压巷内复合支护沿空留巷技术研究

为了减少煤与瓦斯突出矿井煤巷掘进工程量，保证矿井正常接续，针对云盖山煤矿一矿“两软一硬”不稳定煤层地质条件和矿井单一综放工作面组织生产，以矿井22202综采工作面切顶卸压巷内复合支护沿空留巷为研究对象，提出了厚煤层构造带巷内采用工字钢棚+锚索梁支护的沿空留巷围岩控制技术。研究表明:沿空留巷顶板最大移近量72 mm，中线至巷道上帮、下帮最大移近量分别为108 mm、63 mm，留巷工艺流程简单、效果显著，实现了厚煤层构造带切顶卸压巷内复合支护沿空留巷技术的成功应用。     

基于信息熵—集对分析的煤矿隐患排查治理风险评估模型

以煤矿安全隐患排查治理风险为研究对象，分析隐患排查闭环管理全过程，并基于此建立了隐患排查治理能力纵向评估指标体系，融合熵值法和集对分析理论，建立了煤矿安全隐患排查治理风险纵向评估模型，为企业更好地了解自身隐患排查治理能力及变化发展趋势提供参考，最后进行了实例分析。