The Potential Role of Hepatocyte Growth Factor in Degenerative Disorders of the Synovial Joint and Spine

This paper aims to provide a comprehensive review of the changing role of hepatocyte growth factor (HGF) signaling in the healthy and diseased synovial joint and spine. HGF is a multifunctional growth factor that, like its specific receptor c-Met, is widely expressed in several bone and joint tissues. HGF has profound effects on cell survival and proliferation, matrix metabolism, inflammatory response, and neurotrophic action. HGF plays an important role in normal bone and cartilage turnover. Changes in HGF/c-Met have also been linked to pathophysiological changes in degenerative joint diseases, such as osteoarthritis (OA) and intervertebral disc degeneration (IDD). A therapeutic role of HGF has been proposed in the regeneration of osteoarticular tissues. HGF also influences bone remodeling and peripheral nerve activity. Studies aimed at elucidating the changing role of HGF/c-Met signaling in OA and IDD at different pathophysiological stages, and their specific molecular mechanisms are needed. Such studies will contribute to safe and effective HGF/c-Met signaling-based treatments for OA and IDD.     

磨料水射流的切割机理

用磨料水射流对材料进行切割实质上是一个冲蚀作用过程。本文根据磨料颗粒对脆性材料的切割过程,研究了磨料水射流的切割机理,即对物体在磨料水射流冲蚀作用下表面所受的压力及分布、冲蚀破坏的方式及特点进行了探讨,并分析了磨料颗粒的密度、速度及尺寸对磨料水射流冲蚀能效的影响。     

晶核在高性能混凝土中作用机理的试验研究

本文在高性能混凝土中加入晶胚进行试验。通过调整晶胚的细胞和掺量。研究了晶胚对高性能混凝土的强度和耐久性影响的作用机理。结果表明，加入比表面积大干3000cm^2／g的晶胚。最佳掺量为10％时。影响了晶体的大小及分布形态，因而影响了混凝土的强度和耐久性，有力地促进了混凝土后期强度的增长。提高混凝土的抗折，抗压强度。     

地下盐穴处理核废料的方法

核废料对环境和人类安全具有较大危害，如何安全高效处理常常是困扰人类的棘手问题，目前认为有效的处理方式是深部埋藏处理，利用盐穴进行核废料的深埋处理是一种较为安全的方法。盐穴就是在地下盐层中通过钻井，利用水循环的方法，将盐层溶解，最终形成一个体积较大的空洞。利用地下盐穴可以进行各种工业废料的埋藏处理，特别是对具有放射性污染的核废料。建设埋藏放射性核废料的盐穴需要选择地质条件好，具有良好封闭性的盐层中，造穴方式主要是通过水溶洗盐形成地下溶洞。埋藏核废料需要通过一系列的特定工艺才能完成，放射性核废料埋藏处理后需要进行监测以防止产生污染事故。一般来说，由于地下盐穴埋深大、盐穴封闭性好，具有较高的安全性。利用盐穴进行核废料的埋藏具有费用低、容量大、占地少、安全性高等优点，是一种可以推广应用的核废料处理新方法。     

氧化物料制粒技术在ISP烧结工艺中的应用研究

分析了氧化物料直接返回烧结配料的不良影响,介绍了韶关冶炼厂将氧化物料通过制粒应用在生产中,并逐步提升制粒颗粒在烧结配料中的占比,调整烧结过程的工艺参数,逐步改善烧结过程中物料流转状态,使烧结块的产能和电尘的产出逐步形成一种良性的平衡的应用实践。此技术的实施应用有效地提升了烧结车间的烧结块产能,降低ISP工艺原料成本,提升ISP工艺的经济效益和社会效益。     

Fold and flexibility: what can proteins' mechanical properties tell us about their folding nucleus?

The determination of a protein''s folding nucleus, i.e. a set of native contacts playing an important role during its folding process, remains an elusive yet essential problem in biochemistry. In this work, we investigate the mechanical properties of 70 protein structures belonging to 14 protein families presenting various folds using coarse-grain Brownian dynamics simulations. The resulting rigidity profiles combined with multiple sequence alignments show that a limited set of rigid residues, which we call the consensus nucleus, occupy conserved positions along the protein sequence. These residues'' side chains form a tight interaction network within the protein''s core, thus making our consensus nuclei potential folding nuclei. A review of experimental and theoretical literature shows that most (above 80%) of these residues were indeed identified as folding nucleus member in earlier studies.     

Time-dependent changes in eye-specific segregation in the dorsal lateral geniculate nucleus and superior colliculus of postnatal mice

Eye-specific segregation in the dorsal lateral geniculate nucleus （dLGN） and superior colliculus （SC） starts from the embryonic stage and continues to develop postnatally until eye-opening in mice. However, there have been few systematic studies on the details of this developmental process. Here, we carried out time-dependent studies of eye-specific segregation in the dLGN and SC. Our results demonstrated that the development of eye-specific segregation in the SC is completed before postnatal day 12 （P12）, which is earlier than in the dLGN （P20）. During the whole period, ipsilateral and overlapping axonal projections decreased continuously in both the dLGN and SC. On the other hand, contralateral axonal projections showed little change, except for a slight decrease between P8 and P20 in the dLGN.