草原石林：东北亚早白垩世花岗岩伸展穹隆和岩浆成矿爆发的地质遗迹及其形成过程

东北亚地区至少发育9个大型草原石林,属花岗岩石林的一种,是东北亚早白垩世巨量伸展和第四系冰川、风化作用的共同产物,主要特点是发育密集的近水平节理。本文通过整理岩浆岩专题填图和构造研究发现,这些石林的主体是早白垩世东北亚地区巨量伸展过程中形成众多的不对称花岗岩穹隆或同减薄岩体,岩体边部发育韧性剪切带,核部发布近水平岩浆流动面理,伸展和岩浆多期侵位导致与成矿密切相关的岩浆热液大量上涌,岩体抬升至地表,沿岩浆面理发育密集的近水平节理和部分垂直节理,后期沿这些构造面理发生的物理风化和化学作用(包括风蚀、冰川以及盐风化等)造就了千奇百怪的形态。草原石林是花岗岩地貌中的“另类”,不仅具有指示东北亚地区花岗岩形成时代(早白垩世)的特点,也是寻找晚中生代中国北方大规模成矿的良好标志体,而且风化形成的千姿百态的景色极具观赏价值,可以作为整个蒙古草原地区和大兴安岭南段地区特色的地学科普和生态旅游资源。     

Fabrication and Characterization of Highly Oriented Composite Nanofibers with Excellent Mechanical Strength and Thermal Stability

Here, highly‐oriented poly(m‐phenylene isophthalamide)/polyacrylonitrile multi‐walled carbon nanotube (PMIA/PAN‐MWCNT) composite nanofiber membranes with excellent mechanical strength and thermal stability are successfully produced using electrospinning. It is demonstrated that the cooperation of multi‐walled carbon nanotubes (MWCNT) and high‐speed rotating collection is beneficial to the acquisition of highly oriented fibers and effectively improves the mechanical strength of the membrane along the orientation direction. Specifically, the tensile stress of poly(m‐phenylene isophthalamide)/polyacrylonitrile (PMIA/PAN) membrane is enhanced significantly from 10.6 to 20.7 MPa, benefiting from the highly oriented alignment of the fibers as well as the reinforcing effect of MWCNTs on the fibers. Furthermore, the stressing process of single fiber and fiber aggregates is carefully simulated, and the influence of MWCNTs on the mechanical properties of PMIA/PAN‐MWCNT membranes is analyzed comprehensively, providing a meaningful auxiliary means for the study of mechanical properties. In addition, the composite nanofiber membrane has the advantages of both PMIA and PAN, possessing high temperature resistance, flame‐retardancy, and chemical stability, for an ideal high‐temperature material. In short, the as‐prepared PMIA/PAN‐MWCNT composite membrane with excellent comprehensive property emerges a promising application in many fields, especially in high‐tech.     

电液控制系统关键传感器的故障预警方法研究

为了保证电液控制系统的正常运行,对电液控制系统核心传感器部件的故障预警是关键一环,分析了传感器在电液控制系统的工作原理,得到了传感器在系统中的故障规律,为了对井下的电液控制系统中的核心传感器的故障进行预警和诊断,结合目前比较流行的传感器故障预警方法,以液压支架的压力传感器为例,提出了一个静态分析与动态分析融合的诊断方法,其核心是通过对传感器采集的数据进行分析,能有效预测压力传感器故障,提高电液控制系统的可靠性。     

Small-Molecule Inhibitors of METTL3, the Major Human Epitranscriptomic Writer

The RNA methylase METTL3 catalyzes the transfer of a methyl group from the cofactor S-adenosyl-L-methionine (SAM) to the N⁶ atom of adenine. We have screened a library of 4000 analogues and derivatives of the adenosine moiety of SAM by high-throughput docking into METTL3. Two series of adenine derivatives were identified in silico, and the binding mode of six of the predicted inhibitors was validated by protein crystallography. Two compounds, one for each series, show good ligand efficiency. We propose a route for their further development into potent and selective inhibitors of METTL3.     

基于文本与语义相关性分析的图像检索

为了更加有效地检索到符合用户复杂语义需求的图像，提出一种基于文本描述与语义相关性分析的图像检索算法。该方法将图像检索分为两步：基于文本语义相关性分析的图像检索和基于SIFT特征的相似图像扩展检索。根据自然语言处理技术分析得到用户文本需求中的关键词及其语义关联，在选定图像库中通过语义相关性分析得到“种子”图像；接下来在图像扩展检索中，采用基于SIFT特征的相似图像检索，利用之前得到的“种子”图像作为查询条件，在网络图像库中进行扩展检索，并在结果集上根据两次检索的图像相似度进行排序输出，最终得到更加丰富有效的图像检索结果。为了证明算法的有效性，在标准数据集Corel5K和网络数据集Deriantart8K上完成了多组实验，实验结果证明该方法能够得到较为精确地符合用户语义要求的图像检索结果，并且通过扩展算法可以得到更加丰富的检索结果。     

Preclinical Evaluation of 99mTc-ZHER2:41071, a Second-Generation Affibody-Based HER2-Visualizing Imaging Probe with a Low Renal Uptake

Radionuclide imaging of HER2 expression in tumours may enable stratification of patients with breast, ovarian, and gastroesophageal cancers for HER2-targeting therapies. A first-generation HER2-binding affibody molecule [^99mTc]Tc-ZHER2:V2 demonstrated favorable imaging properties in preclinical studies. Thereafter, the affibody scaffold has been extensively modified, which increased its melting point, improved storage stability, and increased hydrophilicity of the surface. In this study, a second-generation affibody molecule (designated ZHER2:41071) with a new improved scaffold has been prepared and characterized. HER2-binding, biodistribution, and tumour-targeting properties of [^99mTc]Tc-labelled ZHER2:41071 were investigated. These properties were compared with properties of the first-generation affibody molecules, [^99mTc]Tc-ZHER2:V2 and [^99mTc]Tc-ZHER2:2395. [^99mTc]Tc-ZHER2:41071 bound specifically to HER2 expressing cells with an affinity of 58 ± 2 pM. The renal uptake for [^99mTc]Tc-ZHER2:41071 and [^99mTc]Tc-ZHER2:V2 was 25–30 fold lower when compared with [^99mTc]Tc-ZHER2:2395. The uptake in tumour and kidney for [^99mTc]Tc-ZHER2:41071 and [^99mTc]Tc-ZHER2:V2 in SKOV-3 xenografts was similar. In conclusion, an extensive re-engineering of the scaffold did not compromise imaging properties of the affibody molecule labelled with ^99mTc using a GGGC chelator. The new probe, [^99mTc]Tc-ZHER2:41071 provided the best tumour-to-blood ratio compared to HER2-imaging probes for single photon emission computed tomography (SPECT) described in the literature so far. [^99mTc]Tc-ZHER2:41071 is a promising candidate for further clinical translation studies.     

Evaluation of particle recovery from microalgae

Coccoliths are micro-structured biomineral particles found in cell protective covering layers of coccolithophore species. They are mainly composed of CaCO₃ and their individual crystal entities are arranged in such a way that they construct complex and unique structures. This complexity is found down to the individual particle level and appears to have promising properties to offer. This study focuses on the essential step prior to any kind of implementation, which is the recovery of the material. It summarizes cleaning protocols found in literature, compares them for the first time for the same freshly cultivated material and addresses challenges that still need to be overcome. Further, it highlight the advantages and disadvantages of the best cleaning protocols, suggests optimizations with promising results and uses size distribution measurements to analyse the recovery efficiency. To that end, further characterization techniques, new for coccoliths, are introduced and used to improve our current knowledge of the particles behaviour.     

用于快速服装搭配的FMatchNet算法

目的 针对现有服装搭配系统中，提取服装图像深度特征进行搭配所需时间过长的问题，提出了一种新的FMatchNet网络提取哈希特征进行服装快速搭配的方法。方法 首先采用快速区域卷积神经网络（Faster-RCNN）方法检测出图像中的服装，用此服装进行搭配可以最大限度地保留服装信息并消除背景信息的干扰。然后用深度卷积神经网络提取服装的深度特征并产生服装的哈希码，采用查询扩展的方法完成服装搭配。模型采用Siamese网络的训练方法使哈希码尽可能保留服装图像的语义信息。另外，由于目前国际上缺少大型时尚服装数据库，本文扩建了一个细粒度标注的时尚服装数据库。结果 在FClothes数据库上验证本文方法并与目前流行的方法进行对比，本文方法在哈希长度为16时，上、下服装搭配方面的准确度达到了50.81%，搭配速度相对于基本准线算法提高了近3倍。结论 针对大规模服装搭配问题，提出一种新的FMatchNet网络提取特征进行服装快速搭配的方法，提高了服装搭配的精度和速度，适用于日常服装搭配。     

Functions of ULK1 in autophagy and non-autophagy pathways and its implications in human physiology and disease

ULK1 (unc-51 like autophagy activating kinase 1), a mammalian serine/threonine kinase, is a key component of autophagy initiation complex and helps to induce all types of autophagy. Canonical autophagy is a process in which, through the interactions of a series of autophagy-related proteins, damaged organelles or misfolded proteins are engulfed by autophagosomes and then merged with lysosomes to be degraded. Thus, canonical autophagy is an important constituent part of the cellular “quality control.” Besides, accumulating evidence indicates that ULK1 exerts autophagy-independent effects in a cell-specific manner. For example, ULK1 facilitates neurite elongation through the regulation of endoplasmic reticulum (ER)–Golgi trafficking in neurons, stimulates phosphopentose pathway to help NADPH (nicotinamide adenine dinucleotide phosphate hydrogen) production, and acts as a duplex regulator in type I IFN (type I interferon) induced innate immune response. Considering the importance and diversity of ULK1 in various biological processes, this review aims to present a comprehensive overview of autophagy and non-autophagy related functions of ULK1 in a variety of human physiological, pathological, and disease processes.     

催化剂WXP-100在棉针织物低温练漂中的应用

为解决纯棉针织物练漂温度高、能耗大等问题,研究自制低温练漂催化剂WXP-100对纯棉针织物练漂一浴前处理效果的影响。优化的低温练漂工艺条件为:催化剂WXP-100质量浓度为2 g/L,氢氧化钠质量浓度为2 g/L,多功能精练剂L质量浓度为6 g/L,30%双氧水体积分数为12 mL/L,70℃处理60 min。研究发现,催化剂WXP-100能够有效促进棉针织物练漂,70℃低温练漂织物的吸水性达到传统高温练漂效果,而且织物的顶破强力保留率高,纤维损伤明显减小,白度略低于传统练漂织物。