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晁浩  阮晓钢 《计算机工程与应用》2005,41(31):178-179,204
基于肿瘤基因表达数据,运用信息科学的方法和技术建立肿瘤的预测分类模型,对肿瘤的识别具有重要意义。针对该类问题,论文提出了一种利用支持向量机进行肿瘤分类与判别的方法。该方法在分析基因表达谱特征的基础上,首先对所有的基因进行聚类,并挑选出每一类的“代表基因”作为特征基因,然后采用支持向量机作为分类器进行肿瘤分类。论文以前列腺癌的基因表达谱数据为例进行分类实验并取得了良好的分类结果,表明了该方法的有效性和可行性。  相似文献
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人体内微最元素浓度的变化预示人体健康状况的改变,对于肿瘤病人尤其重要.本工作收集了93份头发样品,其中包括48个前列腺癌病人和45个作为对照的正常人的头发样品.应用ICP-MS方法测量这些样品中20种微量元素组成,用主成分分析的统计模式识别方法(SPRA-PCA),分析测量结果,以寻求前列腺痛病人头发微量元素的变化特征.结果表明,在20种微量元素中,钙和磷的含量变化与前列腺癌密切相关.于是,用钙和磷的含量构建一个预报前列腺癌的可视化模型,可清晰辨别前列腺癌病人与正常人.为了验证模型的预报能力,用这个模型去预报一组新的样本,预报结果与临床诊断完全相同.  相似文献
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郑光远  刘峡壁  韩光辉 《软件学报》2018,29(5):1471-1514
计算机辅助检测/诊断(Computer-aided Detection/Diagnosis, CAD)能提高诊断准确性,减少假阳性的产生,为医生提供有效的诊断决策支持.本文的主要目的是分析计算机辅助诊断工具的最新发展.文章以CAD研究较多的四大致命性癌症的发病医学部位为主线,按不同的成像技术和病类,对目前CAD在不同医学图像领域的应用进行了较为详尽的综述,从图像数据集、算法和评估方法等方面作多维度梳理.最后分析了医学图像CAD系统研究领域目前存在的问题并对此领域的研究趋势和发展方向进行展望.  相似文献
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Laser surgery, or laser-induced thermal therapy, is a minimally invasive alternative or adjuvant to surgical resection in treating tumors embedded in vital organs with poorly defined boundaries. Its use, however, is limited due to the lack of precise control of heating and slow rate of thermal diffusion in the tissue. Nanoparticles, such as nanoshells, can act as intense heat absorbers when they are injected into tumors. These nanoshells can enhance thermal energy deposition into target regions to improve the ability for destroying larger cancerous tissue volumes with lower thermal doses. The goal of this paper is to present an integrated computer model using a so-called nested-block optimization algorithm to simulate laser surgery and provide transient temperature field predictions. In particular, this algorithm aims to capture changes in optical and thermal properties due to nanoshell inclusion and tissue property variation during laser surgery. Numerical results show that this model is able to characterize variation of tissue properties for laser surgical procedures and predict transient temperature fields comparable to those measured by in vivo magnetic resonance temperature imaging techniques. Note that the computational approach presented in the study is quite general and can be applied to other types of nanoparticle inclusions.  相似文献
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Proteins released from cancer tissues to patient sera can potentially be used to achieve sensitive, specific, and early detection of cancer by means of blood tests. In this study, we used a platform that combines glycopeptide capture, heavy‐isotope‐labeled‐peptide standards, and liquid chromatography coupled to tandem mass spectrometry to determine which glycoproteins from prostate cancer can be detected in sera from patients with early‐stage prostate cancer. The detection limit for prostate‐specific antigen in serum was 3.44 ng/mL; thus, direct identification of low abundance, cancer‐specific proteins was achieved using our platform. We showed that prostatic acid phosphatase and membrane metallo‐endopeptidase that were detected in sera were preferentially expressed in prostate cancer tissues. Levels of these two proteins were elevated in biopsy‐positive patients but not biopsy‐negative groups. Therefore, these two proteins are candidate biomarkers for analysis of patient samples with levels of prostate‐specific antigen in the diagnostic gray zone.  相似文献
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Chemotherapeutic agents as they are used today have limited effectiveness against prostate cancer, but may potentially be used in new combinations with more efficacious results. Mitoxantrone, used for palliation of prostate cancer, has recently been found by our group to improve the susceptibility of primary prostate cancer cells to killing through the Fas‐mediated death pathway. Here we used a shotgun proteomics approach to first profile the entire prostate cancer proteome and then identify specific factors involved in this mitoxantrone response. Peptides derived from primary prostate cancer cells treated with or without 100 nM mitoxantrone were analyzed by multidimensional protein identification technology (MudPIT). Strict limits and data filtering hierarchies were applied to identify proteins with high confidence. We identified 1498 proteins belonging to the prostate cancer proteome, 83 of which were significantly upregulated and 27 of which were markedly downregulated following mitoxantrone treatment. These proteins perform diverse functions, including ceramide production, tumour suppression, and oxidative reduction. Detailed proteomic analyses of prostate cancer cells and their response to mitoxantrone will further our understanding of its mechanisms of action. Identification of proteins influenced by treatment with mitoxantrone or other compounds may lead to the development of more effective drug combinations against prostate cancer.  相似文献
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Expressed prostatic secretions (EPS) contain proteins of prostate origin that may reflect the health status of the prostate and be used as diagnostic markers for prostate diseases including prostatitis, benign prostatic hyperplasia, and prostate cancer. Despite their importance and potential applications, a complete catalog of EPS proteins is not yet available. We, therefore, undertook a comprehensive analysis of the EPS proteome using 2‐D micro‐LC combined with MS/MS. Using stringent filtering criteria, we identified a list of 114 proteins with at least two unique‐peptide hits and an additional 75 proteins with only a single unique‐peptide hit. The proteins identified include kallikrein 2 (KLK2), KLK3 (prostate‐specific antigen), KLK11, and nine cluster of differentiation (CD) molecules including CD10, CD13, CD14, CD26, CD66a, CD66c, CD 143, CD177, and CD224. To our knowledge, this list represents the first comprehensive characterization of the EPS proteome, and it provides a candidate biomarker list for targeted quantitative proteomics analysis using a multiple reaction monitoring (MRM) approach. To help prioritize candidate biomarkers, we constructed a protein–protein interaction network of the EPS proteins using Cytoscape (www.cytoscape.org), and overlaid the expression level changes from the Oncomine database onto the network.  相似文献
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Alpha‐2 macroglobulin (A2M) functions as a universal protease inhibitor in serum and is capable of binding various cytokines and growth factors. In this study, we investigated if immunoaffinity enrichment and proteomic analysis of A2M protein complexes from human serum could improve detection of biologically relevant and novel candidate protein biomarkers in prostate cancer. Serum samples from six patients with androgen‐independent, metastatic prostate cancer and six control patients without malignancy were analyzed by immunoaffinity enrichment of A2M protein complexes and MS identification of associated proteins. Known A2M substrates were reproducibly identified from patient serum in both cohorts, as well as proteins previously undetected in human serum. One example is heat shock protein 90 alpha (HSP90α), which was identified only in the serum of cancer patients in this study. Using an ELISA, the presence of HSP90α in human serum was validated on expanded test cohorts and found to exist in higher median serum concentrations in prostate cancer (n = 18) relative to control (n = 13) patients (median concentrations 50.7 versus 27.6 ng/mL, respectively, p = 0.001). Our results demonstrate the technical feasibility of this approach and support the analysis of A2M protein complexes for proteomic‐based serum biomarker discovery.  相似文献
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