Metformin Preserves β-Cell Compensation in Insulin Secretion and Mass Expansion in Prediabetic Nile Rats

Prediabetes is a high-risk condition for type 2 diabetes (T2D). Pancreatic β-cells adapt to impaired glucose regulation in prediabetes by increasing insulin secretion and β-cell mass expansion. In people with prediabetes, metformin has been shown to prevent prediabetes conversion to diabetes. However, emerging evidence indicates that metformin has negative effects on β-cell function and survival. Our previous study established the Nile rat (NR) as a model for prediabetes, recapitulating characteristics of human β-cell compensation in function and mass expansion. In this study, we investigated the action of metformin on β-cells in vivo and in vitro. A 7-week metformin treatment improved glucose tolerance by reducing hepatic glucose output and enhancing insulin secretion. Although high-dose metformin inhibited β-cell glucose-stimulated insulin secretion in vitro, stimulation of β-cell insulin secretion was preserved in metformin-treated NRs via an indirect mechanism. Moreover, β-cells in NRs receiving metformin exhibited increased endoplasmic reticulum (ER) chaperones and alleviated apoptotic unfold protein response (UPR) without changes in the expression of cell identity genes. Additionally, metformin did not suppress β-cell mass compensation or proliferation. Taken together, despite the conflicting role indicated by in vitro studies, administration of metformin does not exert a negative effect on β-cell function or cell mass and, instead, early metformin treatment may help protect β-cells from exhaustion and decompensation.     

感官代偿在药品盲用无障碍包装设计中的应用研究

目的 针对盲人难以精准、便捷、安全服药的问题，基于感官代偿原理，研究如何利用触觉、听觉等感官代偿的潜在优势设计“适盲性”药品无障碍包装，辅助盲人实现科学、合理、精准用药。方法 基于盲人的生理和心理特点，分析药品包装在适应盲人使用时的“痛点”，在把握盲人感官代偿机理的基础上，结合具体案例，研究药品包装适盲性无障碍设计的途径和方法。结论 在基于盲人特殊的感官代偿机制设计盲用无障碍药品包装时，要理性、深度地思考如何最大限度地激发触觉和听觉的代偿潜能来解决盲人的服药障碍问题。通过简洁规范的盲文标注设计、科学合理的适盲性结构设计、智能交互的语音指令设计等方式，改善药品包装的核心信息呈现方式，提升药品信息传递的便捷性和准确性，使盲人能够独立自主地识药、取药和服药。     

基于CiteSpace的旅游服务设计研究可视化分析

目的 旅游服务设计发展态势良好，从旅游服务设计的角度进行文献可视化分析，可从中获得当前领域的知识结构、研究热点和发展态势，为未来提供旅游服务设计研究和旅游产业的服务设计参考。方法 从CNKI和Web of Science数据库收集1990—2020年国内外的相关数据，运用CiteSpace对旅游服务设计的文献发表时间、高度被引用的文献、研究热点和研究前沿进行可视化分析，比较国内外研究差异。结论 在1990—2020年国内外旅游服务设计研究皆呈上升趋势。国外的研究热度、被引频次高于国内，以跨学科领域研究尤为突出，研究重点在建筑环境和交通相关策略;而国内研究以产品服务系统为主，偏向于技术的实现方式。综观研究现状和趋势，本文从智慧科技旅游、可持续发展和全域旅游进行深入探讨，提出旅游服务设计新发展趋势。     

Photophysical investigation of the formation of defect levels in P doped ZnO thin films

Zinc oxide (ZnO) offers a major disadvantage of asymmetry doping in terms of reliability, stability, and reproducibility of p-type doping, which is the main hindrance in realization of optoelectronic devices. The problem is even more complicated due to formation of various native defects in unintentionally doped n-type ZnO. The realization of p-type conductivity in doped ZnO requires an in-depth understanding of the formation of an effective shallow acceptor, as well as donor-acceptor compensation. Photophysical properties such as photoconductivity along with photoluminescence (PL) studies have unprecedentedly and effectively been utilized in this work to monitor the evolution of various in-gap defects. Phosphorus (P) doped ZnO thin films have been grown by RF magnetron sputtering under various Ar to O₂ gas ratios to investigate the effect of O₂ on the donor-acceptor compensation by comprehensive photoconductivity measurements supported by the PL studies. Initial elemental analyses indicate presence of abundant zinc vacancies (V_Zn) in O-rich ambience. The results predict that P sits in the zinc (Zn) site rather than the oxygen (O) site causing the formation of P_Zn–2V_Zn acceptor-like defects, which compensates the donor defects in P doped ZnO films. Photocurrent spectra uniquely reveal presence of more oxygen vacancies (V_O) defects states in lower O₂ flow, which gets compensated with an increase in the O₂ flow. Successive photocurrent transients indicate probable presence of more V_O in the films grown with lower O₂ flow and more V_Zn in higher O₂ flow. Overall the photosensitivity measurements clearly present that O-rich ambience expedites the formation of acceptor defects which are compensated, thereby lowering the dark current and enhancing the ultraviolet photosensitivity.     

就诊等待服务APP适老化设计研究

目的 将数字化服务融入老年患者就诊流程，建立适老化就诊等待服务系统，在APP开发设计研究中实现软件流程优化。方法 依据ERG理论对老年患者在就诊等待过程中的需求点进行分类整理和层次划分。调研目标用户将分析结果融入服务设计理论，为指导软件开发所涉及的医院就诊流程、用户需求痛点，提出系统性的解决策略。基于交互设计原则展开APP界面设计。结论 构建了以老年患者为中心的就诊等待服务系统，帮助提升其等待过程中的自我效能。完善了基于产品使用方式层级的适老化就诊等待服务APP设计策略，为适老化、数字化产品研发提供了新思路;最终产出APP设计实例，提高了老年群体社会参与度，鼓励老年患者自主就诊，帮助其更加轻松地享受信息化时代带来的红利。     

SRS: Spatial-tagged radio-mapping system combining LiDAR and mobile-phone data for indoor location-based services

One of the most challenging issues in radio received signal strength (RSS)-based localization systems is the generation and distribution of a radio map with a coordinate system linked with spatial information in a large indoor space. This study proposes a novel spatial-tagged radio-mapping system (SRS) that effectively combines the heterogeneous properties of LiDAR and mobile phones to simultaneously perform both spatial and radio mappings. The SRS consists of synchronization, localization, and map building processes, and enables real-time spatial and radio mapping. In the synchronization process, the distance range, motion data, and radio signals obtained through the LiDAR and mobile phone are collected in nodal units according to the sensing time. In the localization process, a feature variance filter is used to control the number of features generated from LiDAR and estimate the positions at which the nodes are generated in real time according to the motion data and radio signals. In map building, the estimated positions of the nodes are used to extract spatial and radio maps by using a unified location coordinate system. To ensure mobility, the SRS is manufactured in the form of a backpack supporting LiDAR and a mobile phone; the usefulness of the system is experimentally verified. The experiments are performed in a large indoor shopping mall with a complex structure. The experimental results demonstrated that a common coordinate system could be used to build spatial and radio maps with high accuracy and efficiency in real time. In addition, the field applicability of the SRS to location-based services is experimentally verified by applying the constructed radio map to well-known fingerprinting algorithms using the heterogeneous mobile phones.     

5G核心网业务模型的智能化预测研究

摘 要：核心网业务模型的建立是5G网络容量规划和网络建设的基础，通过现有方法得到的理论业务模型是静态不可变的且与实际网络存在偏离。为了克服现有5G核心网业务模型与现网模型适配性较差以及规划设备无法满足用户实际业务需求的问题，提出了一种长短期记忆（long short-term memory，LSTM）网络与卷积LSTM （convolution LSTM，ConvLSTM）网络双通道融合的 5G 核心网业务模型预测方法。该方法基于人工智能（artificial intelligence，AI）技术以实现高质量的核心网业务模型的智能预测，形成数据反馈闭环，实现网络自优化调整，助力网络智能化建设。     

省级安播监管系统设计与实现

在广电总局和省局指示精神的指导下,江苏有线三网融合枢纽中心建成了省中心集中汇聚,分中心独立管控的三级安播监管体系。本文从建设目标,网络结构,系统组成等方面介绍了江苏有线安播监管系统,提出了“播监控三维一体”,“省市县三位一体”的省级全覆盖式安播监管体系解决方案。     

Efficiency evaluation of healthcare services in China based on stochastic multicriteria acceptability analysis and directional distance function

Evaluating the efficiency of healthcare services accurately can help in analyzing the rationality of inputs and outputs in such services. Considering the consistency and equity of assessment criteria, this study conducts the stochastic multicriteria acceptability analysis (SMAA-2) with a directional distance function to evaluate the efficiency of healthcare services in 31 provincial administrative regions of mainland China, as observed in 2018. We use SMAA-DDF to explore all the projection directions to the efficient frontier instead of a certain projection direction. We measure the maximum and average efficiencies for each of the 31 provincial healthcare services. Our empirical findings show that only seven provinces achieve optimal healthcare service efficiency; the eastern area performed the best, followed by the central, western, and northeast areas. Furthermore, the path along the projection directions is provided to help inefficient provinces improve their efficiency and obtain the best possible positions.