Effects of multiple freeze–thaw cycles on meat quality,nutrients, water distribution and microstructure in bovine rumen smooth muscle

This study investigated the effect of 5 freeze–thaw cycles (freezing at −18°C for 12 h and then thawing at 4°C for approximately 12 h) on the meat quality, proximate composition, water distribution and microstructure of bovine rumen smooth muscle (BSM). As the number of freeze–thaw cycles increased, BSM pH, shear force, water content and protein content decreased by 3.06%, 35.50%, 14.49% and 21.11%, respectively, whereas BSM thawing loss, cooking loss, pressing loss, total aerobic count (TAC), ash content and fat content increased by 108.12%, 47.75%, 78.33%, 90.99%, 105% and 35.20%, respectively. The freeze–thaw cycles resulted in greater protein and lipid oxidation, as evidenced by a 36.46% reduction in the sulfhydryl content and a 209.06% and 338.46% increase in the carbonyl and malondialdehyde contents, respectively. Ice crystal formation disrupted the structural integrity of the muscle tissue. Low-field nuclear magnetic resonance results showed that the freeze–thaw cycles prolonged the relaxation times (T_2b, T₂₁ and T₂₂), indicating that immobile water shifted to free water, and consequently, free water mobility increased. After 3 freeze–thaw cycles, the decline in shear force slowed, the increase in thawing loss became accelerated, and the TAC approached the domain value (6 log colony-forming units/g). Therefore, the number of freeze–thaw cycles of smooth muscle during transport, storage and distribution should be controlled to 3 or fewer. The current results provide a theoretical basis and data support for the further utilisation and culinary processing of smooth muscle.     

低能量密度炸药连续装药光面爆破技术研究

为了提高光面爆破成型质量，提出了一种低能量密度炸药连续装药光面爆破技术，利用LS DYNA进行数值模拟，对比2#岩石乳化炸药间隔装药和低能量密度炸药连续装药的应力场，然后将此技术用于长九（神山）灰岩矿四号隧洞控制爆破和露天边坡光面爆破。结果表明：2#岩石乳化炸药间隔装药模型中，装药段与非装药段测点应力峰值相差很大；而在低能量密度炸药连续装药模型中，沿炮孔轴向相同爆心距的测点应力峰值保持一致；使用低能量密度炸药进行连续装药，能够避免装药段的过度破坏和非装药段的欠挖，提高残孔率，且省去了导爆索捆绑时间，提高周边孔装药效率，节省了爆破成本。     

水平管内R245fa/R141b沸腾换热特性的实验研究

针对新型混合工质R245fa/R141b，开展水平光滑管(外径10 mm)内工质沸腾换热特性的实验研究，对比纯工质与混合工质的换热性能及4种常用关联式的预测精度。结果表明：纯工质与混合工质的沸腾传热系数均随质量流速和热通量的增加而增大，随饱和压力的增加而减小；随干度的增加，沸腾传热系数均先增大后减小，即存在“过渡干度”，且混合工质的过渡干度大于纯工质；干度小于0.55时，混合工质传热系数小于纯工质；干度大于0.55后，混合工质的传热系数更高；随R245fa质量分数的增加，混合工质的沸腾传热系数增大。在所选关联式中，Gungor-Winterton关联式能准确地预测工质在光滑管内的沸腾换热特性，平均相对误差为16.67%。     

Spatial agglomeration and productivity in Italy: A panel smooth transition regression approach

The paper analyses the nonlinearities in the impact of localization, diversity, urbanization and competition on firm‐level total factor productivity (TFP), using a large sample of Italian firms from 1999 to 2007. We adopt a panel smooth transition regression model, so that the TFP elasticities are free to vary smoothly across two or more extreme values. Results show that localization economies and Jacobian externalities materialize only for values of, respectively, intra‐industry agglomeration and extra‐sectoral diversity above a certain threshold. Local competition exerts a positive effect on productivity, even though the marginal impact shrinks at high levels of competition. We find instead no evidence of diseconomies of agglomeration.     

The Protective Effects of the Autophagic and Lysosomal Machinery in Vascular and Valvular Calcification: A Systematic Review

Background: Autophagy is a highly conserved catabolic homeostatic process, crucial for cell survival. It has been shown that autophagy can modulate different cardiovascular pathologies, including vascular calcification (VCN). Objective: To assess how modulation of autophagy, either through induction or inhibition, affects vascular and valvular calcification and to determine the therapeutic applicability of inducing autophagy. Data sources: A systematic review of English language articles using MEDLINE/PubMed, Web of Science (WoS) and the Cochrane library. The search terms included autophagy, autolysosome, mitophagy, endoplasmic reticulum (ER)-phagy, lysosomal, calcification and calcinosis. Study characteristics: Thirty-seven articles were selected based on pre-defined eligibility criteria. Thirty-three studies (89%) studied vascular smooth muscle cell (VSMC) calcification of which 27 (82%) studies investigated autophagy and six (18%) studies lysosomal function in VCN. Four studies (11%) studied aortic valve calcification (AVCN). Thirty-four studies were published in the time period 2015–2020 (92%). Conclusion: There is compelling evidence that both autophagy and lysosomal function are critical regulators of VCN, which opens new perspectives for treatment strategies. However, there are still challenges to overcome, such as the development of more selective pharmacological agents and standardization of methods to measure autophagic flux.     

浅谈压延铜箔光面色差的成因

针对压延铜箔在表面处理过程中光面易出现色差的问题,从设备、工艺、人员操作等方面进行成因探讨,并给出了应对措施。     

地下水封石油储库硬岩大断面控制爆破

大型地下水封石油储库作为原油战略储备的一种重要手段,在世界范围内被普遍采用。地下水封储库不同于其他岩石地下工程,其跨度大、边墙高、开挖断面特大,同时要求爆破振动低、围岩损伤小、稳定性高,对开挖爆破有着更为严格的要求。本文以华南某地下水封石油储库硬岩特大断面爆破开挖为例,基于钻爆开挖的特殊要求,提出"大洞小打、分部开挖"的施工原则,划大断面为小断面,分层分次爆破。采用复式楔形掏槽、毫秒延迟起爆、周边孔光面爆破等技术,综合选取孔径、孔深、孔距、最小抵抗线、炸药单耗及炮孔数目等参数,精心设计炮孔布置、装药及起爆顺序,给出爆破方案。实践表明,爆破振动、炮孔利用率、壁面成型、开挖进尺等均达到了预期,较好地满足了洞库开挖要求,特大断面硬岩爆破设计能够取得良好的爆破效果,可为类似工程提供借鉴与参考。     

YD-1003型汽封环线切割机改进

YD-1003型汽封环线切割机存在不足,用详实的理论数据对改进加以说明,探讨了该设备的发展方向。文章采用图文并茂的对照方式来说明,比较了以往的不足及改进后达到的预期目的,提高了该型机床的工作效率,降低了事故的发生频率。