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排序方式: 共有6725条查询结果,搜索用时 15 毫秒
1.
Quan Nguyen Minh Quoc Dat Lai Hoang Nguy Minh Minh Tu Tran Kieu Ngoc Lam Gia Uyen Le My Phung Hang Hoang Dung Nguyen Tran Diem Ai Chau Ngoc Thuc Trinh Doan 《International Journal of Food Science & Technology》2022,57(7):4507-4517
To prevent the adulteration of agricultural resources and provide a solution to enhance the green coffee bean supply chain, authentication using the near-infrared spectroscopy (NIRS) technique was investigated. Partial least square with discrimination analysis (PLS-DA) models combined with various preprocessing methods were built from NIR spectra of 153 Vietnamese green coffee samples. The model combined with the standard normal variate and the first order of derivative yielded excellent performance in predicting coffee species with the error cross-validation of 0.0261. PLS-DA model of mean centre and first-order derivative spectra also yielded good performance in verifying geographical indication of green coffee with the error of 0.0656. By contrast, the predicting abilities of post-harvest methods were poor. The overall results showed a high potential of the NIRS in online authentication practices. 相似文献
2.
《Journal of Great Lakes research》2022,48(5):1288-1297
Beginning in 2013, sites at the 128-m bottom depth contour were added to the sampling design of the annual Lake Michigan bottom trawl survey for prey fish, which has been conducted by the U.S. Geological Survey Great Lakes Science Center (GLSC) each fall since 1973, to better assess fish depth distributions in a changing ecosystem. The standard sampling design included bottom depths from 9 to 110 m, although the GLSC also sporadically conducted bottom trawl tows at the 128-m bottom depth contour during 1973–1988. Enactment of this new sampling design in 2013 revealed that mean biomass density of deepwater sculpins (Myoxocephalus thompsonii) at the 128-m depth exceeded the sum of mean biomass densities at shallower depths, indicating that the bulk of the deepwater sculpin population is residing in waters deeper than 110 m. Thus, our findings supported the hypothesis that the depth distribution of the deepwater sculpin population had shifted to deeper waters beginning in 2007, thereby explaining, at least in part, the marked decline in deepwater sculpin abundance since 2006 based on the standard sampling design. In contrast, our results did not support the hypothesis that the slimy sculpin (Cottus cognatus) population had shifted to deeper waters sometime after 2000. A portion of the burbot (Lota lota) population may have also shifted in depth distribution to waters deeper than 110 m after 2007, based on our results. Our findings have served as an impetus to further expand the range of depths sampled in our bottom trawl survey. 相似文献
3.
Mohammad Bani Ismail Peramaiyan Rajendran Hamad Mohammed AbuZahra Vishnu Priya Veeraraghavan 《International journal of molecular sciences》2021,22(8)
Doxorubicin increases endothelial permeability, hence increasing cardiomyocytes’ exposure to doxorubicin (DOX) and exposing myocytes to more immediate damage. Reactive oxygen species are major effector molecules of doxorubicin’s activity. Mangiferin (MGN) is a xanthone derivative that consists of C-glucosylxanthone with additional antioxidant properties. This particular study assessed the effects of MGN on DOX-induced cytotoxicity in human umbilical vein endothelial cells’ (HUVECs’) signaling networks. Mechanistically, MGN dramatically elevated Nrf2 expression at both the messenger RNA and protein levels through the upregulation of the PI3K/AKT pathway, leading to an increase in Nrf2-downstream genes. Cell apoptosis was assessed with a caspase-3 activity assay, transferase-mediated dUTP-fluorescein nick end labeling (TUNEL) staining was performed to assess DNA fragmentation, and protein expression was determined by Western blot analysis. DOX markedly increased the generation of reactive oxygen species, PARP, caspase-3, and TUNEL-positive cell numbers, but reduced the expression of Bcl-2 and antioxidants’ intracellular concentrations. These were effectively antagonized with MGN (20 μM), which led to HUVECs being protected against DOX-induced apoptosis, partly through the PI3K/AKT-mediated NRF2/HO-1 signaling pathway, which could theoretically protect the vessels from severe DOX toxicity. 相似文献
4.
Adult neurogenesis is a highly regulated process during which new neurons are generated from neural stem cells in two discrete regions of the adult brain: the subventricular zone of the lateral ventricle and the subgranular zone of the dentate gyrus in the hippocampus. Defects of adult hippocampal neurogenesis have been linked to cognitive decline and dysfunction during natural aging and in neurodegenerative diseases, as well as psychological stress-induced mood disorders. Understanding the mechanisms and pathways that regulate adult neurogenesis is crucial to improving preventative measures and therapies for these conditions. Accumulating evidence shows that mitochondria directly regulate various steps and phases of adult neurogenesis. This review summarizes recent findings on how mitochondrial metabolism, dynamics, and reactive oxygen species control several aspects of adult neural stem cell function and their differentiation to newborn neurons. It also discusses the importance of autophagy for adult neurogenesis, and how mitochondrial and autophagic dysfunction may contribute to cognitive defects and stress-induced mood disorders by compromising adult neurogenesis. Finally, I suggest possible ways to target mitochondrial function as a strategy for stem cell-based interventions and treatments for cognitive and mood disorders. 相似文献
5.
Ming Zhang Xuefeng Jiang Qicheng Zhang Tao Zheng Mohsen Mohammadniaei Wentao Wang Jian Shen Yi Sun 《Advanced functional materials》2021,31(38):2102274
Immunotherapy is an efficient approach to clinical oncology. However, the immune privilege of the central nervous system (CNS) limits the application of immunotherapeutic strategies for brain cancers, especially glioblastoma (GBM). Tumor resistance to immune checkpoint inhibitors is a further challenge in immunotherapies. To overcome the immunological tolerance of brain tumors, a novel multifunctional nanoparticle (NP) for highly efficient synergetic immunotherapy is reported. The NP contains an anti-PDL1 antibody (aPDL1), upconverting NPs, and the photosensitizer 5-ALA; the surface of the NP is conjugated with the B1R kinin ligand to facilitate transport across the blood-tumor-barrier. Upon irradiation with a 980 nm laser, 5-ALA is transformed into protoporphyrin IX, generating reactive oxygen species. Photodynamic therapy (PDT) further promotes intratumoral infiltration of cytotoxic T lymphocytes and sensitizes tumors to PDL1 blockade therapy. It is demonstrated that combining PDT and aPDL1 can effectively suppress GBM growth in mouse models. The proposed NPs provide a novel and effective strategy for boosting anti-GBM photoimmunotherapy. 相似文献
6.
为了探讨和评估生姜猕猴桃自然酒精发酵醪酵母菌系多样性及其产品的安全性,采用微生物可培养方法对生姜猕猴桃自然酒精发酵中的酵母菌进行分离,并利用5.8S rDNA ITS序列信息分析不同时期生姜猕猴桃自然酒精发酵醪的酵母菌株α多样性和β多样性。结果表明,生姜猕猴桃自然酒精发酵中酵母菌有8属11种,包括假丝酵母、孢汉逊酵母、德巴利酵母、毕赤酵母、伊萨酵母、柯达酵母、梅奇酵母、Meyerozyma。毕赤酵母是生姜猕猴桃自然酒精发酵醪初期和后期的优势酵母菌群,Myerozyma是生姜猕猴桃自然酒精发酵醪初期和中期的优势酵母菌群。α多样性、β多样性分析结果显示,生姜猕猴桃自然酒精发酵中期物种多样性最高,发酵后期酵母菌数与独有酵母菌数最多,物种丰富度最高。 相似文献
7.
为了探究一氧化氮(nitric oxide,NO)熏蒸对哈密瓜采后耐冷性的影响。以"西州密25号"为试材,用60μL/L NO气体熏蒸3 h,分别在(1±0.5℃)、(3±0.5℃)、(5±0.5℃)贮藏。统计冷害发病率和冷害指数,测定过氧化氢酶(catalase,CAT)、过氧化物酶(peroxidase,POD)、超氧化物歧化酶(superoxide dismutase,SOD)活性、超氧阴离子(superoxide anion,O_2~ˉ·)产生速率、过氧化氢(hydrogen peroxide,H_2O_2)含量的变化。结果表明:NO处理能提高SOD、POD活性,抑制O_2~ˉ·产生速率。1℃条件下,果实冷害发病率最高,NO处理能减轻冷害的发生;3℃条件下,对照果实后期出现冷害,但NO处理果实无冷害发生;5℃条件下,果实后期出现冷害和病害症状,NO处理能减轻果实的冷害和病害。说明NO能够提高抗氧化相关酶的活性,抑制活性氧(reactive oxygen species,ROS)的积累,提高果实的耐冷性;3℃条件下,NO熏蒸既能有效维持果实的贮藏品质又能抑制果实冷害的发生。 相似文献
8.
Fruit flesh volatile and carotenoid profile analysis within the Cucumis melo L. species reveals unexploited variability for future genetic breeding 下载免费PDF全文
9.
10.
Ryan S. Hippman Ivan Pavlinov Qiwen Gao Michelle K. Mavlyanova Erica M. Gerlach Prof. Leslie N. Aldrich 《Chembiochem : a European journal of chemical biology》2020,21(21):3137-3145
A systematic, diversity-oriented synthesis approach was employed to access a natural product-inspired flavonoid library with diverse chemical features, including chemical properties, scaffold, stereochemistry, and appendages. Using Cell Painting, the effects of these diversity elements were evaluated, and multiple chemical features that predict biological performance diversity were identified. Scaffold identity appears to be the dominant predictor of performance diversity, but stereochemistry and appendages also contribute to a lesser degree. In addition, the diversity of chemical properties contributed to performance diversity, and the driving chemical property was dependent on the scaffold. These results highlight the importance of key chemical features that may inform the creation of small-molecule, performance-diverse libraries to improve the efficiency and success of high-throughput screening campaigns. 相似文献