纸浆浓度在线测量技术的发展

本文介绍了几种纸浆浓度在线测量技术的常用控制方式、测量原理及最新发展状况，并从技术成长角度探讨了该技术的制约因素及发展趋势。     

药用辅料对CYP3A活性的影响及其对仿制药质量和疗效一致性评价的指导作用

药物制剂的处方和工艺是保证药物质量和疗效的基础，药用辅料是药物制剂处方的重要组成部分。部分药用辅料可影响CYP3A的活性，继而可能影响其底物在体内的代谢和生物利用度。在中国和美国，相对生物利用度是仿制药研究的关键内容。我国正在推进仿制药质量和疗效一致性评价。因此，了解药用辅料对CYP3A的影响及其对一致性评价的指导作用具有十分重要的现实意义。     

快速灵敏的LC-MS/MS法测定人血浆中阿莫西林并应用于两种制剂的一致性评价

目的: 建立快速灵敏的LC-MS/MS法测定人血浆中阿莫西林浓度，并用于两种阿莫西林胶囊的一致性评价。方法: 采用岛津公司LCMS-8060型LC-MS/MS仪，以MRM模式测定阿莫西林（m/z 366.00/114.00）的浓度，d4-阿莫西林作内标（m/z 370.10/114.05），离子源为ESI源。色谱柱选用Waters ACQUITY BEH C18（2.1×50 mm，1.7 μm），梯度洗脱。血浆样本加入内标，经甲醇沉淀蛋白后取上清液进样检测。结果: 所建方法经验证，其线性、准确度、精密度、最低定量限、提取回收率、特异性、基质效应、稳定性等各项指标均符合CFDA的指导原则及最新核查标准要求，并较文献报道中的方法有处理简单、灵敏度高、色谱峰形好的优点。结论: 所建方法快速、灵敏，适用于人血浆中阿莫西林浓度的检测。用于一致性评价的样本实测，两种制剂生物等效。     

Safety performance functions incorporating design consistency variables

Highway design which ensures that successive elements are coordinated in such a way as to produce harmonious and homogeneous driver performances along the road is considered consistent and safe. On the other hand, an alignment which requires drivers to handle high speed gradients and does not meet drivers' expectancy is considered inconsistent and produces higher crash frequency.     

企业社会责任对跨国并购绩效的影响——基于沪深A股上市企业的实证研究

为了帮助我国企业在跨国并购交易中更好地应对因企业社会责任表现所引起的跨国并购风险，平衡好经济利益诉求与社会责任的履行，论文以2009—2017年沪深A股上市公司109起成功的跨国并购事件为研究对象，基于利益相关者理论、社会契约理论与委托代理理论，研究了企业社会责任对于跨国并购绩效的影响，同时考虑了企业所有制、行业一致性和跨国并购经验的调节作用。采用多元回归模型的实证结果表明：1）企业社会责任对跨国并购绩效存在显著的正向影响；2）企业社会责任与跨国并购之间的正向关系受到国有属性与跨国并购经验的负向调节；3）当并购双方属于同一行业时，行业一致性会显著促进企业社会责任对跨国并购绩效的正向影响。建议企业主动披露企业社会责任履行状况并引入国际通行标准，也可借助国际公关公司制定企业社会责任战略。以上研究结论对中国企业履行社会责任方面具有一定的指导意义，同时也为跨国并购绩效的影响因素研究提供了新的理论视角。     

Distributed ledger technology in supply chains: a transaction cost perspective

With the emergence of distributed ledger technology (DLT), numerous practitioners and researchers have proclaimed its beneficial impact on supply chain transactions in the future. However, the vast majority of DLT initiatives are discontinued after a short period. With the full potential of DLT laying far down the road, especially managers in supply chain management (SCM) seek for short-term cost-saving effects of DLT in order to achieve long-term benefits of DLT in the future. However, the extant research has bypassed grounding long-term as well as short-term effects of DLT on supply chain transaction with empirical data. We address this shortcoming, following an abductive research approach and combining empirical data from a multiple case study design with the corresponding literature. Our study reveals that the effects of DLT on supply chain transactions are two-sided. We found six effects of DLT solutions that have a cost-reducing or cost avoidance impact on supply chain transactions. In addition, we found two effects that change the power distribution between buyers and suppliers in transactions and a single effect that reduces the dependency of supply chain transactions on third parties. While cost-reducing and avoidance as well as dependency-reducing effects are positive effects, the change in power distribution might come with disadvantages. With these findings, the paper provides the first empirical evidence of the impact of DLT on supply chain transactions, which will enable managers to improve their assessment of DLT usage in supply chains.     

Hydrodistillation condition adjustment for different material particle sizes: a method to increase batch‐to‐batch quality consistency

Varying material particle sizes represent a common contributing factor to the batch‐to‐batch variation of extraction yields. To increase the batch‐to‐batch quality consistency of extracts, a method was proposed to adjust the extraction conditions for different material particle sizes, taking the hydrodistillation extraction process of Radix Curcumae and Fructus Gardeniae as a case study. Statistical models were built for five sesquiterpenes including curcumenone, curcumenol, curdione, curzerenone and furanodienone, to quantitatively describe the effects of particle size and process parameters on their extraction yields. An increase in sodium chloride concentration remarkably increased the yields of curcumenone and curcumenol, and a larger solvent‐to‐solid ratio increased the yields of five sesquiterpenes. Under the adjusted process parameters for two different particle sizes, the yield for each compound was controlled to fall in the 90–110% target range. The proposed method can be applied to various extraction processes of foods and herbal medicines.     

基于Agent的信任的情感劝说决策模型

基于智能体(Agent)的信任的情感劝说能更好地发挥Agent的各项人工智能优势。针对其中决策模型建立不够的现状,首先基于Agent的自身性格、情感衰减及外界刺激,运用大五性格、OCC情感模型及情感强度第一定律等,构建了相应的情感强度算法;其次考虑交易质量对信任的反馈,综合运用语言评价法、三角模糊数及将模糊数转换为具体分数(CFCS)算法,对Agent的交易质量进行模糊化和去模糊化处理,构建了相应的交易质量算法;再次对已有的信任更新因子进行改进后,构建了Agent的信任更新算法;最后在构建以上算法的基础上,采用交互式多准则决策(TODIM)法建立了基于Agent的信任的情感劝说决策模型,并采用熵权法对模型中的属性权重进行设定。为验证以上研究的合理性和有效性,设计了相应算例进行阐述,分析了不同参数取不同值得到的决策结果,并与相关研究进行了比较分析,得出了相应结论和管理启示,进一步归纳了不足之处和未来研究方向。     

农村工业化地区的城市更新:从破碎到整合——以佛山市南海区为例

空间破碎是农村工业化地区实施城市更新的主要制约,如何整合是重要的实践和学术课题。本文以“问题-对策”为分析框架,以佛山市南海区为例,从广度层面揭示出三类空间破碎及其对改造的约束机理和现有改造的整合特征,并通过深度的案例比较探究空间整合的关键所在。研究发现:物质和权属的空间破碎是该类地区的典型特征,改造又衍生出政策空间破碎;破碎增加交易成本,阻碍用地整合;现实中的整合改造是少数;在市场资本的驱动下,政府推动整合的效果显著。以“交易中间人”的角色统筹改造彰显出政府降低交易成本以协同市场的职能回归。     

高分子建筑防水材料工业生产中的卫生防护(上)

对高分子建筑防水材料工业生产中的卫生危害及卫生防护进行了概貌性地评述。