Lipidomic Analysis of Plasma from Healthy Men and Women Shows Phospholipid Class and Molecular Species Differences between Sexes

The phospholipid composition of lipoproteins is determined by the specificity of hepatic phospholipid biosynthesis. Plasma phospholipid 20:4n-6 and 22:6n-3 concentrations are higher in women than in men. We used this sex difference in a lipidomics analysis of the impact of endocrine factors on the phospholipid class and molecular species composition of fasting plasma from young men and women. Diester species predominated in all lipid classes measured. 20/54 Phosphatidylcholine (PtdCho) species were alkyl ester, 15/48 phosphatidylethanolamine (PtdEtn) species were alkyl ester, and 12/48 PtdEtn species were alkenyl ester. There were no significant differences between sexes in the proportions of alkyl PtdCho species. The proportion of alkyl ester PtdEtn species was greater in women than men, while the proportion of alkenyl ester PtdEtn species was greater in men than women. None of the phosphatidylinositol (PtdIns) or phosphatidylserine (PtdSer) molecular species contained ether-linked fatty acids. The proportion of PtdCho16:0_22:6, and the proportions of PtdEtn O-16:0_20:4 and PtdEtn O-18:2_20:4 were greater in women than men. There were no sex differences in PtdIns and PtdSer molecular species compositions. These findings show that plasma phospholipids can be modified by sex. Such differences in lipoprotein phospholipid composition could contribute to sexual dimorphism in patterns of health and disease.     

Deterministic and probabilistic ship pitch prediction using a multi-predictor integration model based on hybrid data preprocessing,reinforcement learning and improved QRNN

The deterministic and probabilistic prediction of ship motion is important for safe navigation and stable real-time operational control of ships at sea. However, the volatility and randomness of ship motion, the non-adaptive nature of single predictors and the poor coverage of quantile regression pose serious challenges to uncertainty prediction, making research in this field limited. In this paper, a multi-predictor integration model based on hybrid data preprocessing, reinforcement learning and improved quantile regression neural network (QRNN) is proposed to explore the deterministic and probabilistic prediction of ship pitch motion. To validate the performance of the proposed multi-predictor integrated prediction model, an experimental study is conducted with three sets of actual ship longitudinal motions during sea trials in the South China Sea. The experimental results indicate that the root mean square errors (RMSEs) of the proposed model of deterministic prediction are 0.0254°, 0.0359°, and 0.0188°, respectively. Taking series #2 as an example, the prediction interval coverage probabilities (PICPs) of the proposed model of probability predictions at 90%, 95%, and 99% confidence levels (CLs) are 0.9400, 0.9800, and 1.0000, respectively. This study signifies that the proposed model can provide trusted deterministic predictions and can effectively quantify the uncertainty of ship pitch motion, which has the potential to provide practical support for ship early warning systems.     

A constrained portfolio selection model at considering risk-adjusted measure by using hybrid meta-heuristic algorithms

Portfolio selection is a key issue in the business world and financial fields. This article presents a new decision making method of portfolio optimization (PO) issues in different risk measures by using new evolutionary computing method and cardinality constrains which is mentioned as hybrid meta-heuristic algorithms. Based on mean–variance (MV) Method by Markowitz we collected three risk levels; mean absolute deviation (MAD), semi variance (SV) and variance with skewness (VWS). The developed algorithms are Electromagnetism-like algorithm (EM), particle swarm optimization (PSO), genetic algorithm (GA), genetic network programming (GNP) and simulated annealing (SA). Also a diversification mechanism strategy is implemented and hybridized with the developed algorithms to increase the diversity and overcome local optimality. The sustainability of this proposed model is verified by 50 factories on the Iranian stock exchange. Finally, experimental results of proposed algorithms with cardinality constraint are compared with each other by four effective metrics in which the algorithms performance for achieving the optimal solution discussed. In addition, we have done the analysis of variance technique to confirm the validity and accurately analyze of the results which the success of this method was proved.     

Gender differences in the addiction to social networks in the Southern Spanish university students

Social networks sites have become the most popular instrument used to communicate and exchange information resulting in the addiction to this media. Previous studies suggested that personal characters play an essential role in addictive behavior and gender difference may be involved. Nevertheless, there are contradictions about the influence of gender. Some studies indicated higher addiction in men. Meanwhile, other researchers pointed out higher addiction among Spanish teenage female. Little studies in the Spanish context have analyzed the different socio-cultural and biological factors possibly related to this addiction and gender differences. With all being said, this study focused on determining the current incidence of social networks addiction in young college students, relating this social networking addiction with loneliness, prenatal testosterone (2D:4D ratio), self-esteem and personal satisfaction. A cross-sectional study focused on female and male college students aged 17–25 years (N = 278) was carried out. It was used several surveys, including the Social Network Addiction Questionnaire (SNA) and the 2D:4D ratio. The results showed difference among male and female about addiction (chi-square = 12.77, p-value = 0.002). Moreover, this addiction was linked with several factors, such as importance given to social networks by females (p-value < 0.001) and males (p-value < 0.001). Also, the findings showed that addiction to social networks might be influenced by gender, showing more importance sociopsychological factors in females and a combination of biological and social factors in the men. Moreover, Instagram has increased as the predominant social network for communication for college students (97.2% men and 93.7% women).     

Adolescents’ comments in social media: Why do adolescents receive negative feedback and who is most at risk?

Receiving negative peer feedback in social media may have negative consequences for adolescents’ psychosocial development and well-being. Therefore, the first aim of this study was to investigate online behavior (i.e., online social exploration, risky online self-presentation) that predicts receiving negative online peer feedback. The second aim was to examine three types of precursors that may predict this online behavior and, indirectly, negative feedback: (a) developmental (i.e., sex, age), (b) dispositional (i.e., sensation seeking, inhibitory control), and (c) social precursors (i.e., peer problems, family conflict). We collected survey data among 785 Dutch adolescents (10–15 years old). Our results showed that adolescents who engaged in online social exploration and risky online self-presentation more often, were more likely to receive negative peer feedback. Online social exploration was more prevalent among the older adolescents and adolescents characterized by higher sensation seeking and more family conflict. In addition, risky online self-presentation was more prevalent among adolescents high in sensation seeking. Consequently, these adolescents’ online behavior, indirectly, made them more at risk of receiving negative peer feedback in social media.     

基于优化初始聚类中心的K中心点算法

针对K中心点算法的初始聚类中心可能过于临近、代表性不足、稳定性差等问题，提出一种改进的K中心点算法。将样本集间的平均距离与样本间的平均距离的比值作为样本的密度参数，精简了高密度点集合中候选代表点的数量，采用最大距离乘积法选择密度较大且距离较远的K个样本作为初始聚类中心，兼顾聚类中心的代表性和分散性。在UCI数据集上的实验结果表明，与传统K中心点算法和其他2种改进聚类算法相比，新提出的算法不仅聚类结果更加准确，同时也具有更快的收敛速度和更高的稳定性。     

Modelling consumer choice through the random regret minimization model: An application in the food domain

In line with findings on post-purchase food-choice regret, one can expect that pre-purchase anticipated regret with respect to forgone (non-chosen) alternatives has an impact on consumer food choices, especially when the choice is considered to be important. The traditional Random Utility Maximization (RUM) models for discrete choices may not fully capture this impact. This study investigates the usefulness and potential in the food domain of a discrete choice model that follows the regret minimization principle, the Random Regret Minimization (RRM) model, as an alternative and complement to existing RUM models. The two models are applied to consumer stated choices of cheese in a choice experiment. The study also investigates whether and to what extent a number of personality traits determine whether particular consumers rather choose according to utility-maximization, or regret-minimization principles. Results show that at the aggregate level the two models have a similar goodness of fit to the data and prediction ability. Still, each of them shows better fit for particular subgroups of consumers, based on personality traits. Hence, the present study reveals a potential for the RRM model applications in the food domain, and adds to the empirical literature supporting previous findings on the RRM model found in other contexts. Further research is needed to explore in which situations and for which consumer segments the RRM model is the most useful model.     

Color evolution during a coating process of pharmaceutical tablet cores by random spraying

Placebo white tablet cores (lactose anhydrous [47.6%], corn starch [23.8%], microcrystalline cellulose [19.1%], polyvinylpyrrolidone [7.9%], magnesium stearate [0.8%], and talcum powder [0.8%]) were coated with a colorant (hydroxypropyl methylcellulose [8% w/v], titanium dioxide [0.2% w/v], FD&C yellow No. 6 with aluminum lacquer [0.8% w/v], polyethylene glycol 4000 [0.4% w/v], and purified water [q.s.p. 100 mL]) using a random spraying method during 130 minutes. During the coating process, batches of 21 samples were extracted every 10 minutes and measured with a DigiEye imaging system. The initial cores showed very similar and uniform colors (Mean Color Difference from the Mean [MCDM] of 0.8 CIELAB units), but partially coated tablets showed lower uniformity (MCDM below 2.0 CIELAB units). There was a high color variability (MCDM about 4.0 CIELAB units) among tablets of the same batch in the period between 10 and 30 minutes, which decreased as the coating process progressed, until achieving a final acceptable value (MCDM below 2.0 CIELAB units). During the coating process, L^* decreased, C^*_ab strongly increased, and h _ab remained nearly constant (disregarding results at 0 and 10 minutes). CIELAB and CIEDE2000 color differences (mainly chroma differences) with respect to the initial color of the tablets were modeled as a function of time by exponential functions with three coefficients. The color change in the interval from 90 to 130 minutes (4.3 CIELAB units, or 2.6 CIEDE2000 units), may be considered negligible bearing in mind the color variability in the batches of 21 samples and typical values of visual color thresholds.     

求解绝对值方程的捕鱼算法

提出一种求解绝对值方程的捕鱼算法。算法首先将绝对值问题转化为一个最小化问题,然后使用三种搜索模式对目标函数进行寻优。数值实验结果表明,与粒子群算法和人群搜索算法以及他们的改进算法相比,所提算法不仅获得了稳定的求解结果,而且在最小值、最大值、平均值和方差等指标上均明显优于其他对比算法。