Diporphyrin tweezer for multichannel spectroscopic analysis of enantiomeric excess

Chiral 1,1’-binaphthyl-linked diporphyrin ‘tweezers’ (R)-1/(S)-1 and the corresponding zinc(II) complexes (R)-2/(S)-2 were prepared as chiral host molecules, and their utility for chiral analyses (especially enantiomeric excess (ee) determinations) were evaluated. Tris(1-n-dodecyl)porphyrins were used for the first time as the interacting units. Host capabilities of the diporphyrin tweezers were investigated by titrations with (R,R)- and (S,S)-cyclohexane-1,2-diamine (CHDA). The host molecules could be used as multichannel probes of ee by using UV-vis, circular dichroism (CD), fluorescence emission and ¹H nuclear magnetic resonance (¹H-NMR) methods. Chiral configurations could also be differentiated using CD or ¹H-NMR spectroscopy. All three optical techniques give good resolution of ee with reasonable sensitivity considering the low concentrations used (ca. 10⁻⁶ mol·L⁻¹). The ee determination of CHDA enantiomers using NMR spectroscopy is also possible because of the reasonably well separated resonances in the case of (R,R)- and (S,S)-CHDA. Non-metallated (R)-1/(S)-1 hosts could not be used to detect chiral information in a strongly acidic chiral guest. This work demonstrates the utility of 1,1’-binapthyl-linked chiral hosts for chiral analysis of ditopically interacting enantiomers.     

Nonoperative management of secondary shoulder impingement syndrome

Shoulder pain secondary to impingement of the rotator cuff tendons underneath the coracoacromial arch is a common problem seen in athletes who perform repetitive overhead activities. Shoulder impingement has been classified into primary and secondary types. Several factors contribute to impingement, including rotator cuff weakness, posterior capsule tightness, and subacromial crowding. Recently, it has been proposed that scapulothoracic muscle weakness could be a factor that contributes to impingement. Traditional rehabilitation protocols for shoulder impingement syndrome stress individualized rotator cuff strengthening. The authors propose that individualized scapulothoracic muscle strengthening should be a part of any protocol for nonoperative treatment of secondary shoulder impingement syndrome.     

Enhancing the US Navy's GIDB Portal with Web Services

Using Web services, the authors have been able to increase the amount of data accessible through the Naval Research Laboratory’s Geospatial Information Database (GIDB) portal. They created a Web crawler for Web Mapping Services (WMS) that harvests and adds data to the portal index and a translator that provides access to non-WMS data through the WMS interface. The Integrated Web Services Broker, using traditional Web services standards, provides automated access to meteorological and oceanographic data.     

A model-based method for organizing tasks in product development

This research is aimed at structuring complex design projects in order to develop better products more quickly. We use a matrix representation to capture both the sequence of and the technical relationships among the many design tasks to be performed. These relationships define the technical structure of a project, which is then analyzed in order to find alternative sequences and/or definitions of the tasks. Such improved design procedures offer opportunities to speed development progress by streamlining the inter-task coordination. After using this technique to model design processes in several organizations, we have developed a design management strategy which focuses attention on the essential information transfer requirements of a technical project.     

Nomemclature of the proteins of cow's milk: fourth revision.

This report reviews the nomenclature of the milk proteins of cow's milk in light of more recent advances in our knowledge. With the establishment of the primary structures of a number of these proteins, we now have a definite identification of alphas1-, kappa-, beta-, and the gamma-caseins as well as beta-lactoglobulin and alpha-lactalbumin. On the basis of new information on their primary structures and relationship to beta-casein polymorphs, changes in nomenclature have been recommended for proteins of the gamma-casein fraction. Although the primary structure serves as the unambiguous definition of proteins for which it is known, a more practical identification is necessary. We recommend that their behavior in gel electrophoresis under suitable conditions be employed for this purpose for all of the "major" milk proteins of raw skim milk except the immunoglobulins where, because of their heterogeneity and molecular genetics, physical parameters are less useful and their identification must be based upon antigenic determinants and their homology with their human counterparts. More work is needed and, with the accumulation of more information, additional changes in nomenclature can be expected for such proteins as the minor components of alphas- and kappa-caseins, alpha-lactalbumin, and the proteose-peptone fraction as well as further confirmation of the presence of immunoglobulins IgE and additional IgG subclasses. Additional components and genetic variants also can be expected.     

Effect of microstructure on friability in the system Al2O3-ZrO2

This paper summarizes results on the use of quantitative microscopy in relating microstructural features to the friability of a model abrasive material, Al₂O₃-ZrO₂. Quantitative stereology was used to characterize the geometric aspects of the microstructure of fused Al₂O₃-ZrO₂ abrasives and to relate these to friability. The microstructure was controlled by varying processing parameters. The quench rate of the material from the melt was found to exhibit the most control over the microstructure. The friability was measured using three methods: the ball mill test, a DeBeers Friatester and a microfriability test developed for this study. Friability was found to be controlled by the geometric aspects of microstructure. The microstructural parameter which appeared to exert the largest influence over friability was the scale factor $\text{}\text{?}$gl^α. A fracture mechanics approach was employed to explain the observed increase in strength and toughness in Al₂O₃-ZrO₂ materials.