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The correct separation of chromosomes during mitosis is necessary to prevent genetic instability and aneuploidy, which are responsible for cancer and other diseases, and it depends on proper centrosome duplication. In a recent study, we found that Smy2 can suppress the essential role of Mps2 in the insertion of yeast centrosome into the nuclear membrane by interacting with Eap1, Scp160, and Asc1 and designated this network as SESA (S my2, E ap1, S cp160, A sc1). Detailed analysis showed that the SESA network is part of a mechanism which regulates translation of POM34 mRNA. Thus, SESA is a system that suppresses spindle pole body duplication defects by repressing the translation of POM34 mRNA. In this study, we performed a genome-wide screening in order to identify new members of the SESA network and confirmed Dhh1 as a putative member. Dhh1 is a cytoplasmic DEAD-box helicase known to regulate translation. Therefore, we hypothesized that Dhh1 is responsible for the highly selective inhibition of POM34 mRNA by SESA.  相似文献   
3.
A new method based on the differential evolution (DE) algorithm is proposed for antenna-array pattern synthesis with prescribed nulls. The array excitation amplitudes are the only controlling parameters, and the objectives are to synthesize array patterns with nulls imposed on directions of interferences while keeping the sidelobe levels (SLLs) below prescribed levels. Many factors such as the excitation dynamic range ratio, null depth level, null width, and SLLs are taken into account in the synthesis. Simulation results of several typical problems are compared with published results to illustrate the effectiveness of the proposed method. © 2003 Wiley Periodicals, Inc. Int J RF and Microwave CAE 14: 57–63, 2004.  相似文献   
4.
An implementation of the IF section of WCDMA mobile transceivers with a set of two chips fabricated in an inexpensive 0.35-/spl mu/m two-poly three-metal CMOS process is presented. The transmit/receive chip set integrates quadrature modulators and demodulators, wide dynamic range automatic gain control (AGC) amplifiers, with linear-in-decibel gain control, and associated circuitry. This paper describes the problems encountered and the solutions envisaged to meet stringent specifications, with process and temperature variations, thus overcoming the limitations of CMOS devices, while operating at frequencies in the range of 100 MHz-1 GHz. Detailed measurement results corroborating successful application of the new techniques are reported. A receive AGC dynamic range of 73 dB with linearity error of less than /spl plusmn/2 dB and spread of less than 5 dB for a temperature range of -30/spl deg/C to +85/spl deg/C in the gain control characteristic has been measured. The modulator measurement shows a carrier suppression of 35 dB and sideband/third harmonic suppression of over 46 dB. The core die area of each chip is 1.5 mm/sup 2/.  相似文献   
5.
The notion of pseudorandomness is the theoretical foundation on which to consider the soundness of a basic structure used in some block ciphers. We examine the pseudorandomness of the block cipher KASUMI, which will be used in the next‐generation cellular phones. First, we prove that the four‐round unbalanced MISTY‐type transformation is pseudorandom in order to illustrate the pseudorandomness of the inside round function FI of KASUMI under an adaptive distinguisher model. Second, we show that the three‐round KASUMI‐like structure is not pseudorandom but the four‐round KASUMI‐like structure is pseudorandom under a non‐adaptive distinguisher model.  相似文献   
6.
Amorphous boron nitride thin coatings (∼0.2 μm) have been formed on Nicalon and C-Nicaion (pre-carbon-coated Nicalon) yarns via dip coating in boric acid solution followed by heating and nitriding in NH3gas at 1000°C. X-ray photoelectron spectroscopy (XPS) and Auger electron spec-troscopy (AES) studies have shown the formation of boron nitride. The coating was boron rich and contains oxygen. The N/B and O/B ratios range from 0.6 to 0.8 and from 0.1 to 0.25, respectively. Tensile strength measurements revealed that the BN-coated C-Nicalon yarn maintained ∼85% of its original strength while BN-coated Nicalon lost ∼85% of its original strength. Auger depth profiles showed that there was a consumption of carbon during the heating and nitridation process for both BN-coated Nicalon and C-Nicalon fibers. However, the depletion of carbon in BN-coated Nicalon fibers was much more severe than that in BN-coated C-Nicalon fibers.  相似文献   
7.
The PBD-Closure of Constant-Composition Codes   总被引:3,自引:0,他引:3  
We show an interesting pairwise balanced design (PBD)-closure result for the set of lengths of constant-composition codes whose distance and size meet certain conditions. A consequence of this PBD-closure result is that the size of optimal constant-composition codes can be determined for infinite families of parameter sets from just a single example of an optimal code. As an application, the sizes of several infinite families of optimal constant-composition codes are derived. In particular, the problem of determining the size of optimal constant-composition codes having distance four and weight three is solved for all lengths sufficiently large. This problem was previously unresolved for odd lengths, except for lengths seven and eleven.  相似文献   
8.
In the last decade, spatio-temporal database research focuses on the design of effective and efficient indexing structures in support of location-based queries such as predictive range queries and nearest neighbor queries. While a variety of indexing techniques have been proposed to accelerate the processing of updates and queries, not much attention has been paid to the updating protocol, which is another important factor affecting the system performance. In this paper, we propose a generic and adaptive updating protocol for moving object databases with less number of updates between objects and the database server, thereby reducing the overall workload of the system. In contrast to the approach adopted by most conventional moving object database systems where the exact locations and velocities last disclosed are used to predict their motions, we propose the concept of Spatio-temporal safe region to approximate possible future locations. Spatio-temporal safe regions provide larger space of tolerance for moving objects, freeing them from location and velocity updates as long as the errors remain predictable in the database. To answer predictive queries accurately, the server is allowed to probe the latest status of objects when their safe regions are inadequate in returning the exact query results. Spatio-temporal safe regions are calculated and optimized by the database server with two contradictory objectives: reducing update workload while guaranteeing query accuracy and efficiency. To achieve this, we propose a cost model that estimates the composition of active and passive updates based on historical motion records and query distribution. More system performance improvements can be obtained by cutting more updates from the clients, when the users of system are comfortable with incomplete but accuracy bounded query results. We have conducted extensive experiments to evaluate our proposal on a variety of popular indexing structures. The results confirm the viability, robustness, accuracy and efficiency of our proposed protocol.  相似文献   
9.
Chee -Keng Yap 《Algorithmica》1988,3(1-4):279-288
We give a parallel method for triangulating a simple polygon by two (parallel) calls to the trapezoidal map computation. The method is simpler and more elegant than previous methods. Along the way we obtain an interesting partition of one-sided monotone polygons. Using the best-known trapezoidal map algorithm, ours run in timeO(logn) usingO(n) CREW PRAM processors.  相似文献   
10.
The rising production of produced water from oilfields had been proven to bring detrimental environmental effects. In this study, an efficient, recyclable, and environmental-friendly reduced graphene oxide immobilized κ-Carrageenan hydrogel composite(κCa GO) was fabricated as an alternative sorbent for crude oil-in-water demulsification. Polyethyleneimine(PEI) was employed to form a stable hydrogel composite. The conditions for the immobilization of graphene oxide(GO) on PEI-modified κ-Carrageenan(κC) beads were optimized appropriately. An immobilization yield of 77% was attained at 2% PEI, 2 h immobilization activation time, and p H6.5. Moreover, the synthesized κCa GO is capable of demulsification with an average demulsification efficiency of 70%. It was found that the demulsification efficiency increases with salinity and κCa GO dosage, and it deteriorates under alkaline condition. These phenomena can be attributed to the interfacial interactions between κCa GO and the emulsion. Furthermore, the κCa GO can be recycled to use for up to six cycles without significant leaching and degradation. As such, the synthesized κCa GO could be further developed as a potential sorbent substitute for the separation of crude oil from produced water.  相似文献   
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